Results 51 to 60 of about 4,225,584 (267)
Exploring the functional domain and the target of the tetanus toxin light chain in neurohypophysial terminals [PDF]
, 1994 The tetanus toxin light chain blocks calcium induced vasopressin release from neurohypophysial nerve terminals. Here we show that histidine residue 233 within the putative zinc binding motif of the tetanus toxin light chain is essential for the ...
Binz, T. +7 more
core +1 more source
LABORATORY EXAMINATION IN NERVE AGENT INTOXICATION [PDF]
Acta Medica (Hradec Kralove, Czech Republic), 2013 Diagnosis of nerve agent intoxication is based on anamnestic data, clinical signs and laboratory examination. For acute poisoning, cholinesterase activity in the blood (erythrocyte AChE, plasma/serum BuChE) is sensitive, simple and most frequent laboratory examination performed in biochemical laboratories. Specialized examinations to precise treatment (
Jiří Bajgar, Jiří Bajgar
openaire +4 more sources
Medical management of hereditary optic neuropathies. [PDF]
, 2014 Hereditary optic neuropathies are diseases affecting the optic nerve. The most common are mitochondrial hereditary optic neuropathies, i.e., the maternally inherited Leber's hereditary optic neuropathy (LHON) and dominant optic atrophy (DOA).
Barboni, Piero +4 more
core +1 more source
Esters of organophosphorus acids: Toxicity, application and removal from the environment [PDF]
Scientific Technical Review, 2019 Esters of organophosphorus acids (OPs) are widely used nowadays. They have an application as pesticides, drugs or chemical warfare agents. Their acute toxicity is ascribed to the inhibition of acetylcholinesterase (AChE), a key enzyme in the transmission
Anićijević Vladan J. +3 more
doaj
Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention
Biomolecules, 2020 This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer’s disease, or as a warfare ...
Samir F. de A. Cavalcante +7 more
doaj +1 more source
Sensors, 2009 A cholinesterase based biosensor was constructed in order to assess the effects of ionizing radiation on exposed AChE. Although the primary objective of the experiment was to investigate the effect of ionizing radiation on the activity of the biosensor ...
Miroslav Pohanka, Miroslav Koch
doaj +1 more source
Intraoperative Neurophysiological Monitoring for Endoscopic Endonasal Approaches to the Skull Base: A Technical Guide. [PDF]
, 2016 Intraoperative neurophysiological monitoring during endoscopic, endonasal approaches to the skull base is both feasible and safe. Numerous reports have recently emerged from the literature evaluating the efficacy of different neuromonitoring tests during
Doan, Adam T. +6 more
core +3 more sources
Pharmacological Blockade of the Calcium Plateau Provides Neuroprotection Following Organophosphate Paraoxon Induced Status Epilepticus in Rats [PDF]
, 2016 Organophosphate (OP) compounds which include nerve agents and pesticides are considered chemical threat agents. Currently approved antidotes are crucial in limiting OP mediated acute mortality.
Ajdacic-Gross +43 more
core +2 more sources
Química NovaStraightforward, microscale, Ellman's cholinesterase test procedures are presented, useful for screening of novel compounds aiming at neurodegenerative diseases and antidotes towards nerve agents and pesticides.
Samir F. de A. Cavalcante +6 more
doaj +1 more source
Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds
Beilstein Journal of Organic Chemistry, 2016 The aim of this review is to provide an update on the current use of cyclodextrins against organophosphorus compound intoxications. Organophosphorus pesticides and nerve agents play a determinant role in the inhibition of cholinesterases.
Sophie Letort +4 more
doaj +1 more source