Results 81 to 90 of about 4,225,584 (267)

HI-6-loaded PEGylated liposomes: an on-site first-aid strategy for acute organophosphorus agent poisoning

Drug Delivery, 2023
Organophosphorus agents, also known as nerve agents, are very dangerous chemicals that were used as chemical warfare agents. HI-6 is one of the most promising reactivators which is effective in reactivating AChE inhibited by many nerve agents.
Liao Shen, Yadan Zhang, Qimei Cai, Jun Yang, Yongan Wang, Dongqin Quan   +5 more
doaj   +1 more source

Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.

Journal of Medicinal Chemistry, 2018
Six chlorinated bispyridinium mono-oximes, analogous to potent charged reactivators K027, K048, and K203, were synthesized with the aim of improving lipophilicity and reducing the p Ka value of the oxime group, thus resulting in a higher oximate ...
Tamara Zorbaz, D. Maliňák, N. Maraković, N. Maček Hrvat, A. Zandona, Michal Novotný, A. Skarka, Rudolf Andrýs, Marketa Benkova, O. Soukup, M. Katalinić, K. Kuča, Z. Kovarik, K. Musílek   +13 more
semanticscholar   +1 more source

TSE pathogenesis in cattle and sheep [PDF]

, 2008
Many studies have been undertaken in rodents to study the pathogenesis of transmissible spongiform encephalopathies (TSE). Only a few studies have focused on the pathogenesis of bovine spongiform encephalopathy (BSE) and scrapie in their natural hosts ...
Bossers, A., Keulen, L.J.M., van, Zijderveld, F.G., van   +2 more
core   +3 more sources

Analysis of Organophosphorus-Based Nerve Agent Degradation Products by Gas Chromatography-Mass Spectrometry (GC-MS): Current Derivatization Reactions in the Analytical Chemist’s Toolbox

Molecules, 2021
The field of gas chromatography-mass spectrometry (GC-MS) in the analysis of chemical warfare agents (CWAs), specifically those involving the organophosphorus-based nerve agents (OPNAs), is a continually evolving and dynamic area of research.
Carlos A. Valdez, Roald N. Leif
doaj   +1 more source

Oral Inflammation, Tooth Loss, Risk Factors, and Association with Progression of Alzheimer’s Disease [PDF]

, 2014
Periodontitis is a polymicrobial chronic inflammatory disease of tooth-supporting tissues with bacterial etiology affecting all age groups, becoming chronic in a subgroup of older individuals.
Crean, Stjohn, Harding, Alice, Kesavalu, Lakshmyya, Robinson, Sarita Jane, Simmons, Tal, Singhrao, Simarjit Kaur   +5 more
core   +1 more source

Is there a "safety zone" in the mandibular premolar region where damage to the mental nerve can be avoided if periapical extrusion occurs? [PDF]

, 2010
The mandibular premolars are located close to the mental foramina (Fig. 1). As such, various events affecting these teeth, such as odontogenic infection1 and orthodontic, endodontic, periodontal or surgical misadventure, may result in neurosensory ...
Ngeow, Dr. W.C.
core   +2 more sources

New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics

Biomolecules
New furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus ...
Milena Mlakić, Tena Čadež, Goran Šinko, Irena Škorić, Zrinka Kovarik   +4 more
doaj   +1 more source

Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents.

Journal of Medicinal Chemistry, 2018
Acetylcholinesterase (AChE), a key enzyme in the central and peripheral nervous systems, is the principal target of organophosphorus nerve agents. Quaternary oximes can regenerate AChE activity by displacing the phosphyl group of the nerve agent from the
G. Santoni, Julien de Sousa, E. de la Mora, J. Dias, L. Jean, J. Sussman, I. Silman, P. Renard, Richard C. D. Brown, M. Weik, R. Baati, F. Nachon   +11 more
semanticscholar   +1 more source

First Supramolecular Sensors for Phosphonate Anions [PDF]

, 2013
Fluorescent tripodal anion sensors with a 1,3,5-triethylbenzene core display a turn-on fluorescence response to phosphonate and phosphate anions and may be used as optical sensors.
Anzenbacher, Pavel, Esipenko, Nina A., Koutnik, Petr, Lynch, Vincent M., Minami, Tsuyoshi, Mosca, Lorenzo, Zyryanov, Grigory V.   +6 more
core   +1 more source

Analysis of chemical warfare agents by gas chromatography-mass spectrometry: methods for their direct detection and derivatization approaches for the analysis of their degradation products

Reviews in Analytical Chemistry, 2017
Chemical warfare agents (CWAs) are unarguably one of the most feared toxic substances produced by mankind. Their inception in conventional warfare can be traced as far back as the Middle Ages but their full breakthrough as central players in bellic ...
Valdez Carlos A., Leif Roald N., Hok Saphon, Hart Bradley R.   +3 more
doaj   +1 more source