Iron role paradox in nerve degeneration and regeneration [PDF]
Physiological ReportsIron accumulates in the neural tissue during peripheral nerve degeneration. Some studies have already been suggested that iron facilitates Wallerian degeneration (WD) events such as Schwann cell de‐differentiation.
Samira Bolandghamat +1 more
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Ingenuity pathway analysis of gene expression profiles in distal nerve stump following nerve injury: insights into Wallerian degeneration [PDF]
Frontiers in Cellular Neuroscience, 2016 Nerve injury is a common and difficult clinical problem worldwide with a high disability rate. Different from the central nervous system, the peripheral nervous system is able to regenerate after injury.
Jun Yu, Xiaosong Gu, Sheng Yi
doaj +3 more sources
Relationship of distraction rate with inferior alveolar nerve degeneration-regeneration shift [PDF]
Neural Regeneration Research, 2018 Distraction osteogenesis is an important technique for the treatment of maxillofacial abnormities and defects. However, distraction osteogenesis may cause the injury of the inferior alveolar nerve.
Ying-hua Zhao +6 more
doaj +3 more sources
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain. [PDF]
Acta Neuropathol Commun, 2021 Pain is a common non-motor symptom of Parkinson’s disease (PD), with current limited knowledge of its pathophysiology. Here, we show that peripheral inoculation of mouse alpha-synuclein (α-Syn) pre-formed fibrils, in a transgenic mouse model of PD ...
Ferreira N +7 more
europepmc +2 more sources
Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice. [PDF]
J Neuroinflammation, 2020 The risk of glaucoma increases significantly with age and exposure to elevated intraocular pressure, two factors linked with neuroinflammation. The complement cascade is a complex immune process with many bioactive end-products, including mediators of ...
Harder JM +7 more
europepmc +2 more sources
Characterising cellular and molecular features of human peripheral nerve degeneration. [PDF]
Acta Neuropathol Commun, 2020 Nerve regeneration is a key biological process in those recovering from neural trauma. From animal models it is known that the regenerative capacity of the peripheral nervous system (PNS) relies heavily on the remarkable ability of Schwann cells to ...
Wilcox MB +6 more
europepmc +2 more sources
Pathogenic Role of PPARα Downregulation in Corneal Nerve Degeneration and Impaired Corneal Sensitivity in Diabetes. [PDF]
Diabetes, 2020 The purpose of this study was to investigate the protective role of peroxisome proliferator–activated receptor α (PPARα) against diabetic keratopathy and corneal neuropathy.
Matlock HG +8 more
europepmc +2 more sources
Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging
Nature Communications, 2016 Sensitive and label-free imaging methods to visualize nerve degeneration are currently lacking. Here authors show that stimulated Raman scattering (SRS) microscopy can be used to monitor peripheral nerve degeneration in mouse models of amyotrophic ...
Feng Tian +20 more
doaj +2 more sources
VIII. The chemistry of nerve-degeneration [PDF]
Philosophical Transactions of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1901 In a former paper we have shown that in the disease called General Paralysis of the Insane the degenerative changes that occur in the central nervous system are associated with the presence of the products of such degeneration in the cerebrospinal fluid.
Frederick Walker Mott +1 more
openaire +5 more sources
Retinal and optic nerve degeneration in liver X receptor β knockout mice. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance Optic neuritis, an inflammatory disease of the optic nerve, leads to death of retinal ganglion cells (RGC) and impaired vision. Both LXRα and LXRβ are expressed in the retina and optic nerve.
Song XY +8 more
europepmc +2 more sources