Axonal protection by short-term hyperglycemia with involvement of autophagy in TNF-induced optic nerve degeneration [PDF]
Frontiers in Cellular Neuroscience, 2015 Previous reports showed that short-term hyperglycemia protects optic nerve axons in a rat experimental hypertensive glaucoma model. In this study, we investigated whether short-term hyperglycemia prevents tumor necrosis factor (TNF)-induced optic nerve ...
Kana eSase +5 more
doaj +3 more sources
Relationship of distraction rate with inferior alveolar nerve degeneration-regeneration shift [PDF]
Neural Regeneration Research, 2018 Distraction osteogenesis is an important technique for the treatment of maxillofacial abnormities and defects. However, distraction osteogenesis may cause the injury of the inferior alveolar nerve.
Ying-hua Zhao +6 more
doaj +3 more sources
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain. [PDF]
Acta Neuropathol Commun, 2021 Pain is a common non-motor symptom of Parkinson’s disease (PD), with current limited knowledge of its pathophysiology. Here, we show that peripheral inoculation of mouse alpha-synuclein (α-Syn) pre-formed fibrils, in a transgenic mouse model of PD ...
Ferreira N +7 more
europepmc +2 more sources
Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice. [PDF]
J Neuroinflammation, 2020 The risk of glaucoma increases significantly with age and exposure to elevated intraocular pressure, two factors linked with neuroinflammation. The complement cascade is a complex immune process with many bioactive end-products, including mediators of ...
Harder JM +7 more
europepmc +2 more sources
Characterising cellular and molecular features of human peripheral nerve degeneration. [PDF]
Acta Neuropathol Commun, 2020 Nerve regeneration is a key biological process in those recovering from neural trauma. From animal models it is known that the regenerative capacity of the peripheral nervous system (PNS) relies heavily on the remarkable ability of Schwann cells to ...
Wilcox MB +6 more
europepmc +2 more sources
Pathogenic Role of PPARα Downregulation in Corneal Nerve Degeneration and Impaired Corneal Sensitivity in Diabetes. [PDF]
Diabetes, 2020 The purpose of this study was to investigate the protective role of peroxisome proliferator–activated receptor α (PPARα) against diabetic keratopathy and corneal neuropathy.
Matlock HG +8 more
europepmc +2 more sources
Neural Regeneration Research, 2022 Wallerian degeneration is a complex biological process that occurs after nerve injury, and involves nerve degeneration and regeneration. Schwann cells play a crucial role in the cellular and molecular events of Wallerian degeneration of the peripheral ...
Min Cai +8 more
doaj +2 more sources
Iron role paradox in nerve degeneration and regeneration [PDF]
Physiological ReportsIron accumulates in the neural tissue during peripheral nerve degeneration. Some studies have already been suggested that iron facilitates Wallerian degeneration (WD) events such as Schwann cell de‐differentiation.
Samira Bolandghamat +1 more
doaj +2 more sources
Journal of Neuroinflammation, 2021 Background Plenty of macrophages are recruited to the injured nerve to play key roles in the immunoreaction and engulf the debris of degenerated axons and myelin during Wallerian degeneration, thus creating a conducive microenvironment for nerve ...
Jiawei Xu +11 more
doaj +2 more sources
Peripheral nerve mucoid degeneration involving the sciatic nerve
Pathologica, 2019 Peripheral nerve mucoid degeneration (PNMD) is a rare non-neoplastic degenerative condition characterized by endoneural deposit of mucoid matrix. Herein, we report a case of PNMD involving the sciatic nerve with preoperative features, surgical treatment and pathological findings.
Viscardo Paolo Fabbri +3 more
openalex +4 more sources