Results 141 to 150 of about 1,249,880 (378)

Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma

PLoS Genetics, 2012
Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide. Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk alleles for glaucoma-related optic nerve disease.
J. Wiggs, B. Yaspan, M. Hauser, J. Kang, R. Allingham, L. Olson, W. Abdrabou, B. Fan, Dan-yi Wang, W. Brodeur, D. Budenz, J. Caprioli, A. Crenshaw, K. Crooks, E. Delbono, K. Doheny, D. Friedman, D. Gaasterland, T. Gaasterland, C. Laurie, Richard K. Lee, P. Lichter, S. Loomis, Yutao Liu, F. Medeiros, C. Mccarty, D. Mirel, S. Moroi, D. Musch, A. Realini, F. Rozsa, J. Schuman, Kathleen M. Scott, Kuldev Singh, J. Stein, E. Trager, P. Vanveldhuisen, D. Vollrath, G. Wollstein, Sachiko Yoneyama, Kang Zhang, R. Weinreb, J. Ernst, Manolis Kellis, T. Masuda, D. Zack, J. Richards, M. Pericak-Vance, L. Pasquale, J. Haines   +49 more
semanticscholar   +1 more source

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source

Proper microsurgical nerve suture may impede Wallerian degeneration of completely transected nerves: an electron microscopic study

Arquivos de Neuro-Psiquiatria, 1983
Electron microscopic findings on the nerve of the biventer cervicis muscle of the chick, which was completely transected and immediately after submitted to an adequate microsurgical nerve suture, confirmed our previous statement that proper microsurgical
Eros Abrantes Erhart, Ciro Ferreira da Silva, Claudio Fava Chagas   +2 more
doaj   +1 more source

The Dynamics of Nerve Degeneration and Regeneration in a Healthy Milieu and in Diabetes. [PDF]

Int J Mol Sci, 2023
Dahlin LB.
europepmc   +1 more source

Chronic nerve root entrapment: compression and degeneration [PDF]

Journal of Neural Engineering, 2013
Electrode mounts are being developed to improve electrical stimulation and recording. Some are tight-fitting, or even re-shape the nervous structure they interact with, for a more selective, fascicular, access. If these are to be successfully used chronically with human nerve roots, we need to know more about the possible damage caused by the long-term
openaire   +3 more sources

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Memantine Exacerbates Trimethyltin‐Induced Neurodegeneration and Delays Cognitive Impairment Recovery

Neuropsychopharmacology Reports
Trimethyltin (TMT), a type of organotin compound, induces neuronal loss in specific brain regions and cognitive impairments. These changes are transient and followed by recovery, thereby indicating a model of transient brain damage.
Yusuke Onaka, Taro Yamaguchi, Takumu Yamasaki, Koki Morishige, Masanori Yoneyama   +4 more
doaj   +1 more source

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

Advanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans, Anna P. Constantinou, Matthew J. Kibble, Valeria Nele, Daniel Reumann, Luca Bau, Sebastien J. P. Callens, James P. K. Armstrong, Nicolas Newell, Constantin C. Coussios, Molly M. Stevens, Michael D. Gray   +11 more
wiley   +1 more source

Polydopamine Nanoparticles Attenuate Retina Ganglion Cell Degeneration and Restore Visual Function After Optic Nerve Injury [PDF]

, 2021
Xiaotong Lou, Yuanyuan Hu, Hong Zhang, Jia Liu, Yin Zhao   +4 more
openalex   +1 more source

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source