Results 61 to 70 of about 1,249,880 (378)

CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

Molecular Neurodegeneration, 2020
Background Glaucoma is a leading neurodegenerative disease affecting over 70 million individuals worldwide. Early pathological events of axonal degeneration and retinopathy in response to elevated intraocular pressure (IOP) are limited and not well ...
Prabhavathi Maddineni, Ramesh B. Kasetti, Pinkal D. Patel, J. Millar, Charles Kiehlbauch, A. Clark, G. Zode   +6 more
semanticscholar   +1 more source

6-Hydroxy flavone rescue ethanol-induced apoptotic neurodegeneration via activation of p-Akt signaling pathway in the developing mice brain

Khyber Medical University Journal
Objective: To investigate the potential use of 6-Hydroxyflavone (6-HF) activation of phosphorylated Akt (p-Akt) to reduce neurodegeneration induced by Ethanol in the developing mice brain of post-natal day 7 (PND-7) mice.
Mahia Tayyab, Rifat Jahan, Nousheen Bibi, Hafsa Nawaz, Amin Jan, Shahid Ali Shah   +5 more
doaj   +1 more source

Selective Fiber Degeneration in the Peripheral Nerve of a Patient With Severe Complex Regional Pain Syndrome

Frontiers in Neuroscience, 2018
Aims: Complex regional pain syndrome (CRPS) is characterized by chronic debilitating pain disproportional to the inciting event and accompanied by motor, sensory, and autonomic disturbances. The pathophysiology of CRPS remains elusive.
Adrien Yvon, Adrien Yvon, Alessandro Faroni, Adam J. Reid, Adam J. Reid, Vivien C. Lees   +5 more
doaj   +1 more source

OPA1-related auditory neuropathy: site of lesion and outcome of cochlear implantation. [PDF]

, 2015
Hearing impairment is the second most prevalent clinical feature after optic atrophy in Dominant Optic Atrophy associated with mutations in the OPA1 gene.
Arslan, E, Biscaro, A, Cama, Elona, Caporali, L, Carelli, V., La Morgia, C, Liguori, R, Magnavita, V, Monteleone, A, Rossi, R, Santarelli, Rosamaria, Scimemi, Pietro, Valentino, Ml   +12 more
core   +3 more sources

A Novel Reporter Mouse Uncovers Endogenous Brn3b Expression. [PDF]

, 2019
Brn3b (Pou4f2) is a class-4 POU domain transcription factor known to play central roles in the development of different neuronal populations of the Central Nervous System, including retinal ganglion cells (RGCs), the neurons that connect the retina with ...
Cheema, Simranjeet K, La Torre, Anna, Mercado-Ayon, Yesica, Miltner, Adam M, Zawadzki, Robert J, Zhang, Pengfei   +5 more
core   +1 more source

Topical recombinant human Nerve growth factor (rh-NGF) is neuroprotective to retinal ganglion cells by targeting secondary degeneration

Scientific Reports, 2020
Optic neuropathy is a major cause of irreversible blindness worldwide, and no effective treatment is currently available. Secondary degeneration is believed to be the major contributor to retinal ganglion cell (RGC) death, the endpoint of optic ...
Li Guo, B. Davis, N. Ravindran, J. Galvao, Neel Kapoor, N. Haamedi, E. Shamsher, V. Luong, E. Fico, M. Cordeiro   +9 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Differential gene and protein expression between rat tibial nerve and common peroneal nerve during Wallerian degeneration

Neural Regeneration Research, 2019
Wallerian degeneration and nerve regeneration after injury are complex processes involving many genes, proteins and cytokines. After different peripheral nerve injuries the regeneration rate can differ.
Yao-Fa Lin, Zheng Xie, Jun Zhou, Gang Yin, Hao-Dong Lin   +4 more
doaj   +1 more source

The Septum Inguinalis: A Clue to Hernia Genesis?

Journal of Investigative Surgery, 2020
Purpose: Double ipsilateral inguinal (“pantaloon”) hernias and also the more advanced “combined” inguinal hernia involve disruption of the inguinal floor.
Giuseppe Amato,, Piergiorgio Calò,, Vito Rodolico,, Roberto Puleio,, Antonino Agrusa,, Leonardo Gulotta,, Luca Gordini,, Giorgio Romano,   +7 more
doaj   +1 more source

Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis. [PDF]

, 2019
BACKGROUND:Retinal optical coherence tomography (OCT) is a clinical and research tool in multiple sclerosis, where it has shown significant retinal nerve fiber (RNFL) and ganglion cell (RGC) layer thinning, while postmortem studies have reported RGC loss.
Aktas, Orhan, Albrecht, Philipp, Balk, Lisanne J, Cordano, Christian, Cruz-Herranz, Andrés, Dietrich, Michael, Fischer, Dietmar, Green, Ari J, Hallenberger, Angelika, Hartung, Hans-Peter, Hecker, Christina, Hilla, Alexander M, Ingwersen, Jens, Issberner, Andrea, Lehmann-Horn, Klaus, Levin, Marc H, von Gall, Charlotte, Yiu, Hao H, Zamvil, Scott S   +18 more
core   +1 more source