Results 11 to 20 of about 1,892,908 (403)

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection [PDF]

Journal of Cell Biology, 1987
The intact sciatic nerve contains levels of nerve growth factor (NGF) that are comparable to those of densely innervated peripheral target tissues of NGF-responsive (sympathetic and sensory) neurons.
R. Heumann, S. Korsching, C. Bandtlow, H. Thoenen   +3 more
semanticscholar   +3 more sources

Chitin Conduits with Different Inner Diameters at Both Ends Combined with Dual Growth Factor Hydrogels Promote Nerve Transposition Repair in Rats

Journal of Functional Biomaterials, 2023
Severe peripheral nerve injuries, such as deficits over long distances or proximal nerve trunk injuries, pose complex reconstruction challenges that often result in unfavorable outcomes.
Fengshi Zhang, Bo Ma, Qicheng Li, Meng Zhang, Yuhui Kou   +4 more
doaj   +1 more source

Exposure to nerve growth factor worsens nephrotoxic effect induced by Cyclosporine A in HK-2 cells. [PDF]

PLoS ONE, 2013
Nerve growth factor is a neurotrophin that promotes cell growth, differentiation, survival and death through two different receptors: TrkA(NTR) and p75(NTR).
Donatella Vizza, Anna Perri, Danilo Lofaro, Giuseppina Toteda, Simona Lupinacci, Francesca Leone, Paolo Gigliotti, Teresa Papalia, Renzo Bonofiglio   +8 more
doaj   +1 more source

Nerve Growth Factor Compromise in Down Syndrome

Frontiers in Aging Neuroscience, 2021
The basal forebrain cholinergic system relies on trophic support by nerve growth factor (NGF) to maintain its phenotype and function. In Alzheimer’s disease (AD), basal forebrain cholinergic neurons (BFCNs) undergo progressive atrophy, suggesting a ...
Sonia Do Carmo, Benjamin Kannel, A. Claudio Cuello, A. Claudio Cuello, A. Claudio Cuello, A. Claudio Cuello   +5 more
doaj   +1 more source

Aligned PCL Fiber Conduits Immobilized with Nerve Growth Factor Gradients Enhance and Direct Sciatic Nerve Regeneration

Advanced Functional Materials, 2020
Topographical guidance and chemotaxis are crucial factors for peripheral nerve regeneration. This study describes the preparation of highly aligned poly(ε‐caprolactone) (PCL) fiber conduits coated with a concentration gradient of nerve growth factor (NGF)
Lei Zhu, Shuaijun Jia, Tuan-jiang Liu, Liang Yan, Dageng Huang, Zhi-yuan Wang, Shi Chen, Zheng-ping Zhang, Wenwu Zeng, Ying Zhang, Hao Yang, D. Hao   +11 more
semanticscholar   +1 more source

Nerve growth factor and post-infarction cardiac remodeling

Acta Biomedica Scientifica, 2022
The prevalence of sudden death from chronic heart failure and cardiac arrhythmias caused by myocardial infarction is a complex problem in cardiology. Post-infarction cardiac remodeling occurs after myocardial infarction.
O. Yu. Kytikova, T. P. Novgorodtseva, М. V. Antonyuk, Yu. K. Denisenko, O. V. Atamas   +4 more
doaj   +1 more source

Aligned chitosan nanofiber hydrogel grafted with peptides mimicking bioactive brain-derived neurotrophic factor and vascular endothelial growth factor repair long-distance sciatic nerve defects in rats

Theranostics, 2020
Autologous nerve transplantation, which is the gold standard for clinical treatment of peripheral nerve injury, still has many limitations. In this study, aligned chitosan fiber hydrogel (ACG) grafted with a bioactive peptide mixture consisting of RGI ...
F. Rao, Yanhua Wang, Dianying Zhang, Chang‐feng Lu, Z. Cao, Jiajie Sui, Mengjiao Wu, Yawen Zhang, W. Pi, Bo Wang, Y. Kou, Xiumei Wang, Peixun Zhang, B. Jiang   +13 more
semanticscholar   +1 more source

Targeting the Nerve Growth Factor Signaling Impairs the Proliferative and Migratory Phenotype of Triple-Negative Breast Cancer Cells

Frontiers in Cell and Developmental Biology, 2021
Triple-negative breast cancer is a heterogeneous disease that still lacks specific therapeutic approaches. The identification of new biomarkers, predictive of the disease’s aggressiveness and pharmacological response, is a challenge for a more tailored ...
Marzia Di Donato, Giovanni Galasso, Pia Giovannelli, Antonio A. Sinisi, Antimo Migliaccio, Gabriella Castoria   +5 more
doaj   +1 more source

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

Proceedings of the National Academy of Sciences of the United States of America, 1976
A single cell clonal line which responds reversibly to nerve growth factor (NGF) has been established from a transplantable rat adrenal pheochromocytoma. This line, designated PC12, has a homogeneous and near-diploid chromosome number of 40.
L. Greene, A. Tischler
semanticscholar   +1 more source

Local administration of icariin contributes to peripheral nerve regeneration and functional recovery

Neural Regeneration Research, 2015
Our previous study showed that systemic administration of the traditional Chinese medicine Epimedium extract promotes peripheral nerve regeneration. Here, we sought to explore the therapeutic effects of local administration of icariin, a major component ...
Bo Chen, Su-ping Niu, Zhi-yong Wang, Zhen-wei Wang, Jiu-xu Deng, Pei-xun Zhang, Xiao-feng Yin, Na Han, Yu-hui Kou, Bao-guo Jiang   +9 more
doaj   +1 more source