Results 11 to 20 of about 449,708 (260)

Nerve growth factor receptors in dementia [PDF]

, 2015
Background/aim: Nerve growth factor (NGF) promotes the survival and differentiation of sensory and sympathetic neurons. Several studies have found that certain neuropathological factors stimulate NGF receptor expression and release the truncated nerve ...
Mesripour, A., Messripour, M., Mohammadi, I., Nazarian, A.   +3 more
core   +1 more source

Neurotrophic factors and corneal nerve regeneration [PDF]

, 2017
The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination.
Lambiase, Alessandro, Sacchetti, Marta
core   +2 more sources

Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]

, 2017
The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Agostinelli, Enzo, Altissimi, Giancarlo, Artico, Marco, Bardella, Lia, Giangaspero, Felice, Minni, Antonio, Parnigotto, Pier Paolo, Pastore, Francesco Saverio, Spoletini, Marialuisa, Taurone, Samanta, Tombolini, Mario, Wierzbicki, Venceslao   +11 more
core   +1 more source

Angiogenic and Neurotrophic Effects of Human Bone Marrow Mesenchymal Stem Cell-Derived Conditioned Medium for Erectile Dysfunction [PDF]

, 2020
Department of Biomedical EngineeringA three-dimensional spheroid culture system to harvest conditioned medium (CM) from human bone marrow-derived mesenchymal stem cells (hBM-MSCs) with high efficiency were introduced and investigated the therapeutic ...
Kim, Seul Gi
core  

Phase I trial of recombinant human nerve growth factor for neurotrophic keratitis [PDF]

, 2018
Neurotrophic keratitis/keratopathy (NK), a rare degenerative corneal disease, lacks effective pharmacologic therapies.1 Because NK pathology involves trigeminal nerve damage and loss of corneal innervation, nerve growth factor (NGF) is surmised to ...
Alio, Jorge, Allegretti, Marcello, Aragona, Pasquale, Benitez del Castillo, José, Bonini, Stefano, Bonini, Stefano, Bouheraoua, Nacim, Carley, Fiona, Chao, Wendy, Creuzot-Garcher, Catherine, Cursiefen, Claus, Dart, John, De La Paz, Maria, Etxebarria, Jaime, Figueiredo, Francisco, Filatori, Isabella, Fogagnolo, Paolo, Gabison, Eric, Geerling, Gerd, Hossain, Parwez, Kanna, Ramaesh, Koppen, Carina, Kruse, Friedrich, Lambiase, Alessandro, Lambiase, Alessandro, Leonardi, Andrea, Lorenz, Katrin, Malecaze, François, Mantelli, Flavio, Mastropasqua, Leonardo, Mencucci, Rita, Merayo-Lloves, Jesús, Messmer, Elisabeth, Montero, Jesus, Murta, Joaquim Neto, Nemeth, Janos, Rama, Paolo, Rama, Paolo, Rauz, Saaeha, Reinhard, Thomas, Robert, Pierre-Yves, Rolando, Maurizio, Sainz de la Maza, Maite, Szaflik, Jacek P., Torrao, Luis, Wylegala, Edward   +45 more
core   +1 more source

Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice [PDF]

, 2012
Progranulin haploinsufficiency is associated with frontotemporal dementia in humans. Deficiency of progranulin led to exaggerated inflammation and premature aging in mice.
Albuquerque, Boris, Ding, Aihao, Häussler, Annett, Lim, Hee-Young, Myrczek, Thekla, Tegeder, Irmgard   +5 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Targeting the Nerve Growth Factor Signaling Impairs the Proliferative and Migratory Phenotype of Triple-Negative Breast Cancer Cells. [PDF]

, 2021
Triple-negative breast cancer is a heterogeneous disease that still lacks specific therapeutic approaches. The identification of new biomarkers, predictive of the disease’s aggressiveness and pharmacological response, is a challenge for a more tailored
Antimo Migliaccio, Antonio A. Sinisi, Gabriella Castoria, Giovanni Galasso, Marzia Di Donato, Pia Giovannelli   +5 more
core   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Molecular examination of bone marrow stromal cells and chondroitinase ABC-assisted acellular nerve allograft for peripheral nerve regeneration [PDF]

, 2016
The present study aimed to evaluate the molecular mechanisms underlying combinatorial bone marrow stromal cell (BMSC) transplantation and chondroitinase ABC (Ch-ABC) therapy in a model of acellular nerve allograft (ANA) repair of the sciatic nerve gap ...
Deng, Lingxiao, Guan, Li-Xin, Jia, Hua, Li, Wen-Yuan, Liu, Gui-Bo, Liu, Yan-Cui, Wang, Ying   +6 more
core   +1 more source