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Platelet-rich plasma in peripheral nerve injury repair: a comprehensive review of mechanisms, clinical applications, and therapeutic potential [PDF]

Experimental Biology and Medicine
Peripheral nerve injuries (PNIs) pose a significant clinical challenge, often leading to incomplete functional recovery despite current treatments. Platelet-rich plasma (PRP), which contains high levels of growth factors and bioactive molecules, has ...
Kai Shang, Yang Liu, Abdul Qadeer
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Gelatin Methacrylic Acid Hydrogel-Based Nerve Growth Factors Enhances Neural Stem Cell Growth and Differentiation to Promote Repair of Spinal Cord Injury [PDF]

International Journal of Nanomedicine
Mingkui Shen,1,* Lulu Wang,2,* Kuankuan Li,1 Jun Tan,1,3 Zhongxin Tang,1 Xiaohu Wang,4 Hejun Yang1 1Department of Mini-Invasive Spinal Surgery, The Third People’s Hospital of Henan Province, Zhengzhou, Henan, 450006, People’s Republic of China ...
Shen M, Wang L, Li K, Tan J, Tang Z, Wang X, Yang H   +6 more
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Adrenomedullin increases cAMP accumulation and BDNF expression in rat DRG and spinal motor neurons [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Adrenomedullin (AM) has high expression in the spinal cord. In this study, we investigated the expression of AM and its receptor components, including calcitonin receptor-like receptor (CLR) and receptor activity modifying proteins (RAMPs ...
Mohsen Sisakht, Zahra Khoshdel, Amir Mahmoodzadeh, Sayed Mohammad Shafiee, Mohammad Ali Takhshid   +4 more
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The effection of neural apoptosis in the hippocampal formation of rats modal with congenital EDNRB gene defect

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective The purpose of this study is to investigate apoptosis of hippocampal neurons and the expression of glial cell line⁃derived neurotrophic factor (GDNF) and brain⁃derived neurotrophic factor (BDNF) in neonatal pups with EDNRB gene deficiency ...
XIE Dan , SONG Zan⁃min, WANG Xia , ZHANG Yong⁃bo   +3 more
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Roles of the nervous system in pancreatic cancer

Annals of Gastroenterological Surgery, 2021
Pancreatic ductal adenocarcinoma (PDAC), with its extremely poor prognosis, presents a substantial health problem worldwide. Outcomes have improved thanks to progress in surgical technique, chemotherapy, pre‐/postoperative management, and centralization ...
Taiichi Wakiya, Keinosuke Ishido, Tadashi Yoshizawa, Taishu Kanda, Kenichi Hakamada   +4 more
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Chitin Conduits with Different Inner Diameters at Both Ends Combined with Dual Growth Factor Hydrogels Promote Nerve Transposition Repair in Rats

Journal of Functional Biomaterials, 2023
Severe peripheral nerve injuries, such as deficits over long distances or proximal nerve trunk injuries, pose complex reconstruction challenges that often result in unfavorable outcomes.
Fengshi Zhang, Bo Ma, Qicheng Li, Meng Zhang, Yuhui Kou   +4 more
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Functional recovery after peripheral nerve injury via sustained growth factor delivery from mineral-coated microparticles

Neural Regeneration Research, 2021
The gold standard for treating peripheral nerve injuries that have large nerve gaps where the nerves cannot be directly sutured back together because it creates tension on the nerve, is to incorporate an autologous nerve graft.
Daniel J Hellenbrand, Clayton L Haldeman, Jae-Sung Lee, Angela G Gableman, Elena K Dai, Stephen D Ortmann, Jerrod C Gotchy, Kierra K Miller, Adrianna M Doucas, Nicole C Nowak, William L Murphy, Amgad S Hanna   +11 more
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Biological characteristics of dynamic expression of nerve regeneration related growth factors in dorsal root ganglia after peripheral nerve injury

Neural Regeneration Research, 2020
The regenerative capacity of peripheral nerves is limited after nerve injury. A number of growth factors modulate many cellular behaviors, such as proliferation and migration, and may contribute to nerve repair and regeneration.
Yin-Ying Shen, Xiao-Kun Gu, Rui-Rui Zhang, Tian-Mei Qian, Shi-Ying Li, Sheng Yi   +5 more
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Artificial nerve graft constructed by coculture of activated Schwann cells and human hair keratin for repair of peripheral nerve defects

Neural Regeneration Research, 2023
Studies have shown that human hair keratin (HHK) has no antigenicity and excellent mechanical properties. Schwann cells, as unique glial cells in the peripheral nervous system, can be induced by interleukin-1β to secrete nerve growth factor, which ...
Han-Jun Qin, Hang Li, Jun-Ze Chen, Kai-Rui Zhang, Xing-Qi Zhao, Jian-Qiang Qin, Bin Yu, Jun Yang   +7 more
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In vitro study of decellularized rat tissues for nerve regeneration

Frontiers in Neurology, 2022
Peripheral nerve injuries cause an absence or destruction of nerves. Decellularized nerves, acting as a replacement for autografts, have been investigated in the promotion of nerve repair and regeneration, always being incorporated with stem cells or ...
Kai Ye, Andong He, Miaoben Wu, Xiaodong Qiu, Zhiwu Chen, Jun Yin, Jun Yin, Qinghua Song, Yi Huang, Kailei Xu, Kailei Xu, Kailei Xu, Kailei Xu, Kailei Xu, Yuye Huang, Yuye Huang, Peng Wei   +16 more
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