Results 1 to 10 of about 223,909 (214)

Gelatin Methacrylic Acid Hydrogel-Based Nerve Growth Factors Enhances Neural Stem Cell Growth and Differentiation to Promote Repair of Spinal Cord Injury [PDF]

International Journal of Nanomedicine
Mingkui Shen,1,* Lulu Wang,2,* Kuankuan Li,1 Jun Tan,1,3 Zhongxin Tang,1 Xiaohu Wang,4 Hejun Yang1 1Department of Mini-Invasive Spinal Surgery, The Third People’s Hospital of Henan Province, Zhengzhou, Henan, 450006, People’s Republic of China ...
Shen M, Wang L, Li K, Tan J, Tang Z, Wang X, Yang H   +6 more
doaj   +2 more sources

Advances in sciatic nerve regeneration: A review of contemporary techniques [PDF]

Regenerative Therapy
Sciatic nerve injury, affecting the longest and thickest nerve in the human body, often leads to severe pain, weakness, and impaired motor function in the lower extremities.
Sardar Ali, Ming Sun, Muhammad Nadeem Khan, Fang Qiang   +3 more
doaj   +2 more sources

The role of Genipin crosslinked extracellular matrix loaded bFGF in the repair of peripheral nerve injury [PDF]

BMC Biotechnology
Background Biomaterials have been extensively utilized in the field of tissue regeneration and repair. The objective of this study was to develop and assess the efficacy of ECM-G@bFGF in the repair of sciatic nerve injuries.
Yijia Zhang, Gaobao Zhuo, Fangzheng Yu, Xiaodan Xu, Zejing Ruan, Xinyu Hu, Jian Wang, Junyi Zhu   +7 more
doaj   +2 more sources

Adrenomedullin increases cAMP accumulation and BDNF expression in rat DRG and spinal motor neurons [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Adrenomedullin (AM) has high expression in the spinal cord. In this study, we investigated the expression of AM and its receptor components, including calcitonin receptor-like receptor (CLR) and receptor activity modifying proteins (RAMPs ...
Mohsen Sisakht, Zahra Khoshdel, Amir Mahmoodzadeh, Sayed Mohammad Shafiee, Mohammad Ali Takhshid   +4 more
doaj   +1 more source

The effection of neural apoptosis in the hippocampal formation of rats modal with congenital EDNRB gene defect

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective The purpose of this study is to investigate apoptosis of hippocampal neurons and the expression of glial cell line⁃derived neurotrophic factor (GDNF) and brain⁃derived neurotrophic factor (BDNF) in neonatal pups with EDNRB gene deficiency ...
XIE Dan , SONG Zan⁃min, WANG Xia , ZHANG Yong⁃bo   +3 more
doaj   +1 more source

Chitin Conduits with Different Inner Diameters at Both Ends Combined with Dual Growth Factor Hydrogels Promote Nerve Transposition Repair in Rats

Journal of Functional Biomaterials, 2023
Severe peripheral nerve injuries, such as deficits over long distances or proximal nerve trunk injuries, pose complex reconstruction challenges that often result in unfavorable outcomes.
Fengshi Zhang, Bo Ma, Qicheng Li, Meng Zhang, Yuhui Kou   +4 more
doaj   +1 more source

Roles of the nervous system in pancreatic cancer

Annals of Gastroenterological Surgery, 2021
Pancreatic ductal adenocarcinoma (PDAC), with its extremely poor prognosis, presents a substantial health problem worldwide. Outcomes have improved thanks to progress in surgical technique, chemotherapy, pre‐/postoperative management, and centralization ...
Taiichi Wakiya, Keinosuke Ishido, Tadashi Yoshizawa, Taishu Kanda, Kenichi Hakamada   +4 more
doaj   +1 more source

Functional recovery after peripheral nerve injury via sustained growth factor delivery from mineral-coated microparticles

Neural Regeneration Research, 2021
The gold standard for treating peripheral nerve injuries that have large nerve gaps where the nerves cannot be directly sutured back together because it creates tension on the nerve, is to incorporate an autologous nerve graft.
Daniel J Hellenbrand, Clayton L Haldeman, Jae-Sung Lee, Angela G Gableman, Elena K Dai, Stephen D Ortmann, Jerrod C Gotchy, Kierra K Miller, Adrianna M Doucas, Nicole C Nowak, William L Murphy, Amgad S Hanna   +11 more
doaj   +1 more source

Biological characteristics of dynamic expression of nerve regeneration related growth factors in dorsal root ganglia after peripheral nerve injury

Neural Regeneration Research, 2020
The regenerative capacity of peripheral nerves is limited after nerve injury. A number of growth factors modulate many cellular behaviors, such as proliferation and migration, and may contribute to nerve repair and regeneration.
Yin-Ying Shen, Xiao-Kun Gu, Rui-Rui Zhang, Tian-Mei Qian, Shi-Ying Li, Sheng Yi   +5 more
doaj   +1 more source

Artificial nerve graft constructed by coculture of activated Schwann cells and human hair keratin for repair of peripheral nerve defects

Neural Regeneration Research, 2023
Studies have shown that human hair keratin (HHK) has no antigenicity and excellent mechanical properties. Schwann cells, as unique glial cells in the peripheral nervous system, can be induced by interleukin-1β to secrete nerve growth factor, which ...
Han-Jun Qin, Hang Li, Jun-Ze Chen, Kai-Rui Zhang, Xing-Qi Zhao, Jian-Qiang Qin, Bin Yu, Jun Yang   +7 more
doaj   +1 more source