Results 1 to 10 of about 642,413 (264)

Gelatin Methacrylic Acid Hydrogel-Based Nerve Growth Factors Enhances Neural Stem Cell Growth and Differentiation to Promote Repair of Spinal Cord Injury [PDF]

International Journal of Nanomedicine
Mingkui Shen,1,* Lulu Wang,2,* Kuankuan Li,1 Jun Tan,1,3 Zhongxin Tang,1 Xiaohu Wang,4 Hejun Yang1 1Department of Mini-Invasive Spinal Surgery, The Third People’s Hospital of Henan Province, Zhengzhou, Henan, 450006, People’s Republic of China ...
Shen M, Wang L, Li K, Tan J, Tang Z, Wang X, Yang H   +6 more
doaj   +2 more sources

Disruption of spinal cord white matter and sciatic nerve geometry inhibits axonal growth in vitro in the absence of glial scarring [PDF]

BMC Neuroscience, 2001
Background Axons within the mature mammalian central nervous system fail to regenerate following injury, usually resulting in long-lasting motor and sensory deficits.
Crutcher Keith A, Shockley Kristina P, Pettigrew David B   +2 more
doaj   +4 more sources

Factors Within the Endoneurial Microenvironment Act to Suppress Tumorigenesis of MPNST [PDF]

Frontiers in Cellular Neuroscience, 2018
Background: Deciphering avenues to adequately control malignancies in the peripheral nerve will reduce the need for current, largely-ineffective, standards of care which includes the use of invasive, nerve-damaging, resection surgery.
Jo Anne Stratton, Jo Anne Stratton, Jo Anne Stratton, Peggy Assinck, Peggy Assinck, Sarthak Sinha, Ranjan Kumar, Aaron Moulson, Natalya Patrick, Eko Raharjo, Jennifer A. Chan, Jennifer A. Chan, Rajiv Midha, Wolfram Tetzlaff, Jeff Biernaskie, Jeff Biernaskie, Jeff Biernaskie   +16 more
doaj   +4 more sources

An immunoregulation PLGA/Chitosan aligned nanofibers with polydopamine coupling basic fibroblast growth factor and ROS scavenging for peripheral nerve regeneration [PDF]

Materials Today Bio
The repair and functional recovery of long-segment peripheral nerve injuries are crucial in clinical settings. Nerve conduits are seen as promising alternatives to autologous nerve grafts, but their effectiveness is limited by the controlled delivery of ...
Xiaokun Chen, Jihai Xu, Feng Qin, Ziyuan Yang, Xueyuan Li, Miao Yu, Ming Li, Yanhua Wang, Wang Xin   +8 more
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Adrenomedullin increases cAMP accumulation and BDNF expression in rat DRG and spinal motor neurons [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Adrenomedullin (AM) has high expression in the spinal cord. In this study, we investigated the expression of AM and its receptor components, including calcitonin receptor-like receptor (CLR) and receptor activity modifying proteins (RAMPs ...
Mohsen Sisakht, Zahra Khoshdel, Amir Mahmoodzadeh, Sayed Mohammad Shafiee, Mohammad Ali Takhshid   +4 more
doaj   +1 more source

The effection of neural apoptosis in the hippocampal formation of rats modal with congenital EDNRB gene defect

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective The purpose of this study is to investigate apoptosis of hippocampal neurons and the expression of glial cell line⁃derived neurotrophic factor (GDNF) and brain⁃derived neurotrophic factor (BDNF) in neonatal pups with EDNRB gene deficiency ...
XIE Dan , SONG Zan⁃min, WANG Xia , ZHANG Yong⁃bo   +3 more
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Roles of the nervous system in pancreatic cancer

Annals of Gastroenterological Surgery, 2021
Pancreatic ductal adenocarcinoma (PDAC), with its extremely poor prognosis, presents a substantial health problem worldwide. Outcomes have improved thanks to progress in surgical technique, chemotherapy, pre‐/postoperative management, and centralization ...
Taiichi Wakiya, Keinosuke Ishido, Tadashi Yoshizawa, Taishu Kanda, Kenichi Hakamada   +4 more
doaj   +1 more source

Chitin Conduits with Different Inner Diameters at Both Ends Combined with Dual Growth Factor Hydrogels Promote Nerve Transposition Repair in Rats

Journal of Functional Biomaterials, 2023
Severe peripheral nerve injuries, such as deficits over long distances or proximal nerve trunk injuries, pose complex reconstruction challenges that often result in unfavorable outcomes.
Fengshi Zhang, Bo Ma, Qicheng Li, Meng Zhang, Yuhui Kou   +4 more
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Functional recovery after peripheral nerve injury via sustained growth factor delivery from mineral-coated microparticles

Neural Regeneration Research, 2021
The gold standard for treating peripheral nerve injuries that have large nerve gaps where the nerves cannot be directly sutured back together because it creates tension on the nerve, is to incorporate an autologous nerve graft.
Daniel J Hellenbrand, Clayton L Haldeman, Jae-Sung Lee, Angela G Gableman, Elena K Dai, Stephen D Ortmann, Jerrod C Gotchy, Kierra K Miller, Adrianna M Doucas, Nicole C Nowak, William L Murphy, Amgad S Hanna   +11 more
doaj   +1 more source

Biological characteristics of dynamic expression of nerve regeneration related growth factors in dorsal root ganglia after peripheral nerve injury

Neural Regeneration Research, 2020
The regenerative capacity of peripheral nerves is limited after nerve injury. A number of growth factors modulate many cellular behaviors, such as proliferation and migration, and may contribute to nerve repair and regeneration.
Yin-Ying Shen, Xiao-Kun Gu, Rui-Rui Zhang, Tian-Mei Qian, Shi-Ying Li, Sheng Yi   +5 more
doaj   +1 more source