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New England Journal of Medicine, 2010
Osteoarthritis, a common, painful condition, occurs at a rate of 1% per year and affects the majority of people who are over 55 years of age. In a proof-of-concept, phase 2 study in this issue of the Journal, Lane and colleagues1 report that blocking the activity of nerve growth factor with a neutralizing humanized monoclonal antibody (tanezumab) can ...
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Osteoarthritis, a common, painful condition, occurs at a rate of 1% per year and affects the majority of people who are over 55 years of age. In a proof-of-concept, phase 2 study in this issue of the Journal, Lane and colleagues1 report that blocking the activity of nerve growth factor with a neutralizing humanized monoclonal antibody (tanezumab) can ...
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Tissue Localization of Nerve Growth Factor and Nerve Growth Factor Receptors
1991The pioneering investigations of Levi-Montalcini and coworkers established that nerve growth factor (NGF) is an important physiological regulator of neurons of the peripheral nervous system. No doubt in part because of the dramatic and specific effects on the sympathetic and sensory nervous system resulting from immunochemically depriving rodents of ...
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The nerve growth factor family
Progress in Growth Factor Research, 1990Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are small, basic, secretory proteins that allow the survival of specific neuronal populations. In their biologically active form, after cleavage from their biosynthetic precursors, these three neurotrophic proteins, or neurotrophins, show about 50% amino acid ...
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Nerve growth factor and the neostriatum
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19911. The present review summarizes evidence describing the expression, immunoreactivity, binding, transport, development, aging, and functions of NGF in the mammalian neostriatum. 2. Neostriatal NGF binding sites and intrinsic cholinergic neurons are co-localized, increase at a similar rate during ontogeny, and are lost to an equal extent following age ...
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Nerve Growth Factor: Neurotrophin or Cytokine?
International Archives of Allergy and Immunology, 2003Nerve growth factor (NGF) is a neutrophin exerting an important role in the development and functions of the central and peripheral nervous system. However, it has recently been documented that several immune cells – such as mast cells, lymphocytes and eosinophils – produce, store and release NGF.
BONINI, Sergio +4 more
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Regulation of the Synthesis of Nerve Growth Factor and Nerve Growth Factor Receptor
1988The importance of Nerve Growth Factor (NGF) for the development and the maintenance of differentiated properties of peripheral sympathetic and neural crest- derived sensory neurons as well as for basal forebrain cholinergic neurons is well established (cf Levi-Montalcini & Angeletti, 1968; Greene & Shooter, 1980; Thoenen & Barde, 1980; Thoenen et al ...
R. Heumann +7 more
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1990
The discovery of nerve growth factor (NGF) nearly 4 decades ago and the research that followed have had a profound impact upon our understanding of neurotrophic factors and neuronal survival and development. The requirement of NGF by selective neuronal populations implies that many other neurotrophic factors are functioning in the nervous system.
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The discovery of nerve growth factor (NGF) nearly 4 decades ago and the research that followed have had a profound impact upon our understanding of neurotrophic factors and neuronal survival and development. The requirement of NGF by selective neuronal populations implies that many other neurotrophic factors are functioning in the nervous system.
openaire +1 more source