Results 1 to 10 of about 1,438,468 (265)

The gut metabolite indole-3 propionate promotes nerve regeneration and repair

Nature, 2022
The regenerative potential of mammalian peripheral nervous system neurons after injury is critically limited by their slow axonal regenerative rate1. Regenerative ability is influenced by both injury-dependent and injury-independent mechanisms2.
, Guiping Kong, Luming Zhou
exaly   +2 more sources

Magnesium Promotes the Regeneration of the Peripheral Nerve

Frontiers in Cell and Developmental Biology, 2021
Peripheral nerve injury is a common complication in trauma, and regeneration and function recovery are clinical challenges. It is indispensable to find a suitable material to promote peripheral nerve regeneration due to the limited capacity of peripheral
Jingxin Zhang, Binjing Zhang, Jinglan Zhang, Weimin Lin, Shiwen Zhang, Shiwen Zhang   +5 more
doaj   +2 more sources

3D Printed Conductive Multiscale Nerve Guidance Conduit with Hierarchical Fibers for Peripheral Nerve Regeneration

Advancement of science, 2023
Nerve guidance conduits (NGCs) have become a promising alternative for peripheral nerve regeneration; however, the outcome of nerve regeneration and functional recovery is greatly affected by the physical, chemical, and electrical properties of NGCs.
Yongcong Fang, Chengjin Wang, Zibo Liu, Jeonghoon Ko, Li Chen, Ting Zhang, Zhuo Xiong, Lei Zhang, Wei Sun   +8 more
semanticscholar   +1 more source

Self-renewing macrophages in dorsal root ganglia contribute to promote nerve regeneration

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Peripheral sensory neurons situated in dorsal root ganglia (DRG) switch to a regenerative state after nerve injury to enable nerve repair. Axon regeneration is not cell autonomous and is highly influenced by nonneuronal cells.
Rui Feng, Vishnu Muraleedharan Saraswathy, Mayssa H. Mokalled, V. Cavalli   +3 more
semanticscholar   +1 more source

Magnesium‐Encapsulated Injectable Hydrogel and 3D‐Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration

Advancement of science, 2022
Peripheral nerve injury is a challenging orthopedic condition that can be treated by autograft transplantation, a gold standard treatment in the current clinical setting.
Zhi Yao, Weihao Yuan, Jiankun Xu, Wenxue Tong, Jie Mi, P. Ho, D. H. Chow, Ye Li, Hao Yao, Xu Li, Shunxiang Xu, Jiaxin Guo, Qingtang Zhu, L. Bian, Ling Qin   +14 more
semanticscholar   +1 more source

The Time Course of MHC-I Expression in C57BL/6J and A/J Mice Correlates with the Degree of Retrograde Gliosis in the Spinal Cord following Sciatic Nerve Crush

Cells, 2022
The pleiotropic role of the major histocompatibility complex class I (MHC-I) reflects the close association between the nervous and immune systems. In turn, MHC-I upregulation postinjury is associated with a better regenerative outcome in isogenic mice ...
Bruno Henrique de Melo Lima, André Luis Bombeiro, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira   +3 more
doaj   +1 more source

The Effect of Electrical Stimulation on Nerve Regeneration Following Peripheral Nerve Injury

Biomolecules, 2022
Peripheral nerve injuries (PNI) are common and often result in lifelong disability. The peripheral nervous system has an inherent ability to regenerate following injury, yet complete functional recovery is rare.
Luke Juckett, T. Saffari, Benjamin Ormseth, J. Senger, A. Moore   +4 more
semanticscholar   +1 more source

The advanced glycation end-products (AGEs)/ROS/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound healing and nerve regeneration

International Journal on Biological Sciences, 2022
Diabetic keratopathy (DK) is an important diabetic complication at the ocular surface. Chronic low-grade inflammation mediated by the NLRP3 inflammasome promotes pathogenesis of diabetes and its complications.
L. Wan, Xiaofei Bai, Qingjun Zhou, Chen Chen, Huifeng Wang, Ting Liu, Jun-li Xue, Chao Wei, Lixin Xie   +8 more
semanticscholar   +1 more source

Therapeutic Low-Intensity Ultrasound for Peripheral Nerve Regeneration – A Schwann Cell Perspective

Frontiers in Cellular Neuroscience, 2022
Peripheral nerve injuries are common conditions that can arise from trauma (e.g., compression, severance) and can lead to neuropathic pain as well as motor and sensory deficits.
Jenica Acheta, Shannon B. Z. Stephens, Sophie Belin, Y. Poitelon   +3 more
semanticscholar   +1 more source

HDAC-6 inhibition ameliorates the early neuropathology in a mouse model of Krabbe disease

Frontiers in Molecular Neuroscience, 2023
IntroductionIn Krabbe disease (KD), mutations in β-galactosylceramidase (GALC), a lysosomal enzyme responsible for the catabolism of galactolipids, leads to the accumulation of its substrates galactocerebroside and psychosine.
Sandra O. Braz, Marlene M. Morgado, Marta I. Pereira, Ana C. Monteiro, Olga Golonzhka, Matthew Jarpe, Pedro Brites, Monica M. Sousa, Joana Nogueira-Rodrigues   +8 more
doaj   +1 more source