Results 1 to 10 of about 1,563,345 (405)

The gut metabolite indole-3 propionate promotes nerve regeneration and repair

open access: yesNature, 2022
The regenerative potential of mammalian peripheral nervous system neurons after injury is critically limited by their slow axonal regenerative rate1. Regenerative ability is influenced by both injury-dependent and injury-independent mechanisms2.
, Guiping Kong, Luming Zhou
exaly   +2 more sources

A small molecule screen identifies in vivo modulators of peripheral nerve regeneration in zebrafish. [PDF]

open access: yesPLoS ONE, 2017
Adult vertebrates have retained the ability to regenerate peripheral nerves after injury, although regeneration is frequently incomplete, often leading to functional impairments.
Juliane Bremer   +2 more
doaj   +9 more sources

Magnesium Promotes the Regeneration of the Peripheral Nerve

open access: yesFrontiers in Cell and Developmental Biology, 2021
Peripheral nerve injury is a common complication in trauma, and regeneration and function recovery are clinical challenges. It is indispensable to find a suitable material to promote peripheral nerve regeneration due to the limited capacity of peripheral
Jingxin Zhang   +5 more
doaj   +2 more sources

3D Printed Conductive Multiscale Nerve Guidance Conduit with Hierarchical Fibers for Peripheral Nerve Regeneration

open access: yesAdvancement of science, 2023
Nerve guidance conduits (NGCs) have become a promising alternative for peripheral nerve regeneration; however, the outcome of nerve regeneration and functional recovery is greatly affected by the physical, chemical, and electrical properties of NGCs.
Yongcong Fang   +8 more
semanticscholar   +1 more source

Self-renewing macrophages in dorsal root ganglia contribute to promote nerve regeneration

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2023
Significance Peripheral sensory neurons situated in dorsal root ganglia (DRG) switch to a regenerative state after nerve injury to enable nerve repair. Axon regeneration is not cell autonomous and is highly influenced by nonneuronal cells.
Rui Feng   +3 more
semanticscholar   +1 more source

A Bioinspired Self‐Healing Conductive Hydrogel Promoting Peripheral Nerve Regeneration

open access: yesAdvancement of science, 2023
The development of self‐healing conductive hydrogels is critical in electroactive nerve tissue engineering. Typical conductive materials such as polypyrrole (PPy) are commonly used to fabricate artificial nerve conduits.
Hongyun Xuan   +8 more
semanticscholar   +1 more source

The Time Course of MHC-I Expression in C57BL/6J and A/J Mice Correlates with the Degree of Retrograde Gliosis in the Spinal Cord following Sciatic Nerve Crush

open access: yesCells, 2022
The pleiotropic role of the major histocompatibility complex class I (MHC-I) reflects the close association between the nervous and immune systems. In turn, MHC-I upregulation postinjury is associated with a better regenerative outcome in isogenic mice ...
Bruno Henrique de Melo Lima   +3 more
doaj   +1 more source

Enhanced peripheral nerve regeneration by mechano-electrical stimulation

open access: yesbioRxiv, 2023
To address limitations in current approaches for treating large peripheral nerve defects, the presented study evaluated the feasibility of functional material-mediated physical stimuli on peripheral nerve regeneration.
Youyi Tai   +5 more
semanticscholar   +1 more source

Magnesium‐Encapsulated Injectable Hydrogel and 3D‐Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration

open access: yesAdvancement of science, 2022
Peripheral nerve injury is a challenging orthopedic condition that can be treated by autograft transplantation, a gold standard treatment in the current clinical setting.
Zhi Yao   +14 more
semanticscholar   +1 more source

HDAC-6 inhibition ameliorates the early neuropathology in a mouse model of Krabbe disease

open access: yesFrontiers in Molecular Neuroscience, 2023
IntroductionIn Krabbe disease (KD), mutations in β-galactosylceramidase (GALC), a lysosomal enzyme responsible for the catabolism of galactolipids, leads to the accumulation of its substrates galactocerebroside and psychosine.
Sandra O. Braz   +8 more
doaj   +1 more source

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