Results 1 to 10 of about 195,045 (336)

A small molecule screen identifies in vivo modulators of peripheral nerve regeneration in zebrafish. [PDF]

PLoS ONE, 2017
Adult vertebrates have retained the ability to regenerate peripheral nerves after injury, although regeneration is frequently incomplete, often leading to functional impairments.
Juliane Bremer, Julianne Skinner, Michael Granato   +2 more
doaj   +9 more sources

Neurotrophin-3-enhanced nerve regeneration selectively improves recovery of muscle fibers expressing myosin heavy chains 2b [PDF]

, 1997
The purpose of this study was to evaluate the effect of neurotrophin 3 (NT-3) enhanced nerve regeneration on the reinnervation of a target muscle. Muscle fibers can be classified according to their mechanical properties and myosin heavy chain (MHC ...
Airaksinen, Averbuch-Heller, Bar, Bertelli, Braun, Burke, Davis, DiStefano, Eriksson, Ernfors, Fex, Fields, Gillespie, Goldspink, Green, Griesbeck, Henderson, Henderson, Hughes, Isaacson, Izumo, Jansson, Karpati, Kato, Kucera, Kucera, Lefebvre, Lewin, Li, Lindsay, Lohof, Maltin, Oakley, Ozaki, Pellegrino, Peter, Pette, Romanul, Salmons, Schantz, Schiaffino, Schnell, Sterne, Tessarollo, Totosy de Zepetnek, Vejsada, Wang, Wong, Wright   +48 more
core   +3 more sources

Unlocking the potential for optic nerve regeneration over long distances: a multi-therapeutic intervention [PDF]

Frontiers in Neurology
Retinal ganglion cells (RGCs) generally fail to regenerate axons, resulting in irreversible vision loss after optic nerve injury. While many studies have shown that modulating specific genes can enhance RGCs survival and promote optic nerve regeneration,
Zhen-Gang Liu, Zhen-Gang Liu, Lai-Yang Zhou, Lai-Yang Zhou, Lai-Yang Zhou, Lai-Yang Zhou, Yong-Quan Sun, Yong-Quan Sun, Yong-Quan Sun, Yong-Quan Sun, Yi-Hang Ma, Chang-Mei Liu, Chang-Mei Liu, Chang-Mei Liu, Chang-Mei Liu, Bo-Yin Zhang   +15 more
doaj   +2 more sources

The Time Course of MHC-I Expression in C57BL/6J and A/J Mice Correlates with the Degree of Retrograde Gliosis in the Spinal Cord following Sciatic Nerve Crush

Cells, 2022
The pleiotropic role of the major histocompatibility complex class I (MHC-I) reflects the close association between the nervous and immune systems. In turn, MHC-I upregulation postinjury is associated with a better regenerative outcome in isogenic mice ...
Bruno Henrique de Melo Lima, André Luis Bombeiro, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira   +3 more
doaj   +1 more source

HDAC-6 inhibition ameliorates the early neuropathology in a mouse model of Krabbe disease

Frontiers in Molecular Neuroscience, 2023
IntroductionIn Krabbe disease (KD), mutations in β-galactosylceramidase (GALC), a lysosomal enzyme responsible for the catabolism of galactolipids, leads to the accumulation of its substrates galactocerebroside and psychosine.
Sandra O. Braz, Marlene M. Morgado, Marta I. Pereira, Ana C. Monteiro, Olga Golonzhka, Matthew Jarpe, Pedro Brites, Monica M. Sousa, Joana Nogueira-Rodrigues   +8 more
doaj   +1 more source

Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration

Nanotechnology Reviews, 2021
Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration.
Gu Xinyi, Chen Xiaoli, Tang Xiaoxuan, Zhou Zhihao, Huang Tingting, Yang Yumin, Ling Jue   +6 more
doaj   +1 more source

Biomechanical Properties of Bionic Collum Femoris Preserving Hip Prosthesis: A Finite Element Analysis

Orthopaedic Surgery, 2023
Objective Compared with total hip replacement, conventional collum femoris preserving prosthesis has a better bone retention effect. However, damage to the trabecular bone of the proximal femur leads to inevitable abnormal stress distribution, which ...
Xiaomeng Zhang, Yanhua Wang, Lijia Zhang, Kai Yu, Zhentao Ding, Yichong Zhang, Xiaofeng Chen, Chen Xiong, Yun Ji, Dianying Zhang, Xinlong Ma   +10 more
doaj   +1 more source

Comparative intra- and inter-observer reliability of two methods for evaluating intraoperative ultrasonography-based spinal cord hyperechogenicity intensity in degenerative cervical myelopathy

BMC Musculoskeletal Disorders, 2022
Objectives During French-door laminoplasty, a linear array transducer of IOUS was used to observe and record the spinal cord decompression. To acquire a higher-reliability method, and compare the in-observer and inter-observer reliability of two methods ...
Huachuan Wu, Guoliang Chen, Xianlong Li, Zhengya Zhu, Zuofeng Xu, Xizhe Liu, Shaoyu Liu   +6 more
doaj   +1 more source

Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation

Frontiers in Bioengineering and Biotechnology, 2022
Activation of mitophagy was considered to be a potential therapeutic strategy for intervertebral disc degeneration (IDD). There was evidence suggesting that hyaluronic acid (HA) can protect mitochondria from oxidative stress in chondrocytes, but its ...
Fu Zhang, Fu Zhang, Songjuan Wang, Manman Gao, Baoliang Li, Zhongyuan He, Tao Tang, Zhengya Zhu, Shaoyu Liu, Shaoyu Liu, Zhiyu Zhou, Zhiyu Zhou   +11 more
doaj   +1 more source

Nerve commitment in Hydra. I. Role of morphogenetic signals [PDF]

, 1981
The kinetics of nerve commitment during head regeneration in Hydra were investigated using a newly developed assay for committed cells. Committed nerve precursors were assayed by their ability to continue nerve differentiation following explanation of ...
Berking, Bode, Bode, Bode, Bode, Campbell, David, David, David, David, David, Gierer, Hicklin, MacWilliams, MacWilliams, MacWilliams, Schaller, Sproull, Sproull, Tardent, Venugopal, Venugopal, Webster, Webster, Wolpert, Yaross   +25 more
core   +1 more source