Results 11 to 20 of about 1,499,008 (358)

A small molecule screen identifies in vivo modulators of peripheral nerve regeneration in zebrafish [PDF]

PLoS ONE, 2017
Adult vertebrates have retained the ability to regenerate peripheral nerves after injury, although regeneration is frequently incomplete, often leading to functional impairments.
Bremer, Juliane, Skinner, Julianne, Granato, Michael   +2 more
core   +24 more sources

Neurotrophin-3-enhanced nerve regeneration selectively improves recovery of muscle fibers expressing myosin heavy chains 2b [PDF]

, 1997
The purpose of this study was to evaluate the effect of neurotrophin 3 (NT-3) enhanced nerve regeneration on the reinnervation of a target muscle. Muscle fibers can be classified according to their mechanical properties and myosin heavy chain (MHC ...
Airaksinen, Averbuch-Heller, Bar, Bertelli, Braun, Burke, Davis, DiStefano, Eriksson, Ernfors, Fex, Fields, Gillespie, Goldspink, Green, Griesbeck, Henderson, Henderson, Hughes, Isaacson, Izumo, Jansson, Karpati, Kato, Kucera, Kucera, Lefebvre, Lewin, Li, Lindsay, Lohof, Maltin, Oakley, Ozaki, Pellegrino, Peter, Pette, Romanul, Salmons, Schantz, Schiaffino, Schnell, Sterne, Tessarollo, Totosy de Zepetnek, Vejsada, Wang, Wong, Wright   +48 more
core   +4 more sources

Stem‐cell–based therapies to enhance peripheral nerve regeneration [PDF]

Muscle and Nerve, 2020
Peripheral nerve injury remains a major cause of morbidity in trauma patients. Despite advances in microsurgical techniques and improved understanding of nerve regeneration, obtaining satisfactory outcomes after peripheral nerve injury remains a ...
Cederna, Paul S., Grochmal, Joey, Kemp, Stephen W.P., Kubiak, Carrie A., Kung, Theodore A., Midha, Rajiv   +5 more
core   +2 more sources

3D Printed Conductive Multiscale Nerve Guidance Conduit with Hierarchical Fibers for Peripheral Nerve Regeneration

Advancement of science, 2023
Nerve guidance conduits (NGCs) have become a promising alternative for peripheral nerve regeneration; however, the outcome of nerve regeneration and functional recovery is greatly affected by the physical, chemical, and electrical properties of NGCs.
Yongcong Fang, Chengjin Wang, Zibo Liu, Jeonghoon Ko, Li Chen, Ting Zhang, Zhuo Xiong, Lei Zhang, Wei Sun   +8 more
semanticscholar   +1 more source

The gut metabolite indole-3 propionate promotes nerve regeneration and repair

Nature, 2022
The regenerative potential of mammalian peripheral nervous system neurons after injury is critically limited by their slow axonal regenerative rate1. Regenerative ability is influenced by both injury-dependent and injury-independent mechanisms2.
Elisabeth Serger, Lucia Luengo-Gutierrez, Jessica S. Chadwick, G. Kong, Luming Zhou, Greg Crawford, M. Danzi, A. Myridakis, A. Brandis, Adesola T. Bello, Franziska Müller, Alexandros Sanchez-Vassopoulos, Francesco De Virgiliis, Phoebe Liddell, M. Dumas, J. Strid, S. Mani, Dylan Dodd, S. Di Giovanni   +18 more
semanticscholar   +1 more source

Magnesium‐Encapsulated Injectable Hydrogel and 3D‐Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration

Advancement of science, 2022
Peripheral nerve injury is a challenging orthopedic condition that can be treated by autograft transplantation, a gold standard treatment in the current clinical setting.
Zhi Yao, Weihao Yuan, Jiankun Xu, Wenxue Tong, Jie Mi, P. Ho, D. H. Chow, Ye Li, Hao Yao, Xu Li, Shunxiang Xu, Jiaxin Guo, Q. Zhu, L. Bian, Ling Qin   +14 more
semanticscholar   +1 more source

The Effect of Electrical Stimulation on Nerve Regeneration Following Peripheral Nerve Injury

Biomolecules, 2022
Peripheral nerve injuries (PNI) are common and often result in lifelong disability. The peripheral nervous system has an inherent ability to regenerate following injury, yet complete functional recovery is rare.
Luke Juckett, T. Saffari, Benjamin Ormseth, J. Senger, A. Moore   +4 more
semanticscholar   +1 more source

The Time Course of MHC-I Expression in C57BL/6J and A/J Mice Correlates with the Degree of Retrograde Gliosis in the Spinal Cord following Sciatic Nerve Crush

Cells, 2022
The pleiotropic role of the major histocompatibility complex class I (MHC-I) reflects the close association between the nervous and immune systems. In turn, MHC-I upregulation postinjury is associated with a better regenerative outcome in isogenic mice ...
Bruno Henrique de Melo Lima, André Luis Bombeiro, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira   +3 more
doaj   +1 more source

The Role of Neurotropic B Vitamins in Nerve Regeneration

BioMed Research International, 2021
Damage and regeneration naturally occur in the peripheral nervous system. The neurotropic B vitamins thiamine (B1), pyridoxine (B6), and cobalamin (B12) are key players, which maintain the neuronal viability in different ways.
S. Baltrusch
semanticscholar   +1 more source

HDAC-6 inhibition ameliorates the early neuropathology in a mouse model of Krabbe disease

Frontiers in Molecular Neuroscience, 2023
IntroductionIn Krabbe disease (KD), mutations in β-galactosylceramidase (GALC), a lysosomal enzyme responsible for the catabolism of galactolipids, leads to the accumulation of its substrates galactocerebroside and psychosine.
Sandra O. Braz, Marlene M. Morgado, Marta I. Pereira, Ana C. Monteiro, Olga Golonzhka, Matthew Jarpe, Pedro Brites, Monica M. Sousa, Joana Nogueira-Rodrigues   +8 more
doaj   +1 more source