Results 11 to 20 of about 210,044 (358)

Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation

Frontiers in Bioengineering and Biotechnology, 2022
Activation of mitophagy was considered to be a potential therapeutic strategy for intervertebral disc degeneration (IDD). There was evidence suggesting that hyaluronic acid (HA) can protect mitochondria from oxidative stress in chondrocytes, but its ...
Fu Zhang, Fu Zhang, Songjuan Wang, Manman Gao, Baoliang Li, Zhongyuan He, Tao Tang, Zhengya Zhu, Shaoyu Liu, Shaoyu Liu, Zhiyu Zhou, Zhiyu Zhou   +11 more
doaj   +1 more source

The Rate of Regeneration of Nerve [PDF]

Journal of Experimental Biology, 1942
ABSTRACT Five different methods have been used to estimate the rate of advance of regeneration along nerves in the rabbit. Not all give the same result. When the advance of the axon tips is studied a higher rate is recorded than when the times necessary for functional recovery are considered.
E. Gutmann, L. Guttmann, P. B. Medawar, J. Z. Young   +3 more
openaire   +2 more sources

The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter

Cell Reports, 2016
The actin-binding protein adducin was recently identified as a component of the neuronal subcortical cytoskeleton. Here, we analyzed mice lacking adducin to uncover the function of this protein in actin rings.
Sérgio Carvalho Leite, Paula Sampaio, Vera Filipe Sousa, Joana Nogueira-Rodrigues, Rita Pinto-Costa, Luanne Laurel Peters, Pedro Brites, Mónica Mendes Sousa   +7 more
doaj   +1 more source

Acquired ptosis associated with oculomotor and contralateral facial nerve synkinesis: the first reported case [PDF]

, 2017
Evidence of oculomotor nerve (ON) synkinesis is a common occurrence following both acquired and congenital III nerve palsy. It is generally accepted that aberrant regeneration is the likely aetiology of synkinesis in acquired III nerve palsy, following ...
Conversi, Andrea, Di Taranto, Giuseppe, Fino, Pasquale, Gharbiya, Magda, Onesti, Maria Giuseppina, Scuderi, Nicolò, Tarallo, Mauro, Toscani, Marco   +7 more
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Optic Nerve Regeneration [PDF]

Archives of Ophthalmology, 2010
Retinal ganglion cells are usually not able to regenerate their axons after optic nerve injury or degenerative disorders, resulting in lifelong visual loss. This situation can be partially reversed by activating the intrinsic growth state of retinal ganglion cells, maintaining their viability, and counteracting inhibitory signals in the extracellular ...
Larry I, Benowitz, Yuqin, Yin
openaire   +2 more sources

Nerve commitment in Hydra. I. Role of morphogenetic signals [PDF]

, 1981
The kinetics of nerve commitment during head regeneration in Hydra were investigated using a newly developed assay for committed cells. Committed nerve precursors were assayed by their ability to continue nerve differentiation following explanation of ...
Berking, Bode, Bode, Bode, Bode, Campbell, David, David, David, David, David, Gierer, Hicklin, MacWilliams, MacWilliams, MacWilliams, Schaller, Sproull, Sproull, Tardent, Venugopal, Venugopal, Webster, Webster, Wolpert, Yaross   +25 more
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Gpr126/Adgrg6 has Schwann cell autonomous and nonautonomous functions in peripheral nerve injury and repair [PDF]

, 2016
Schwann cells (SCs) are essential for proper peripheral nerve development and repair, although the mechanisms regulating these processes are incompletely understood.
Carlin, Dan, Cavalli, Valeria, Harty, Breanne L, Joseph, Jessica, Mogha, Amit, Monk, Kelly R, Piao, Xianhua, Sanchez, Nicholas E, Suter, Ueli   +8 more
core   +2 more sources

Primary Bone Marrow Mesenchymal Stromal Cells Rescue the Axonal Phenotype of Twitcher Mice

Cell Transplantation, 2014
Krabbe's disease (KD) is a demyelinating disorder caused by the deficiency of lysosomal galactocerebrosi-dase (GALC), affecting both the central (CNS) and the peripheral nervous system (PNS).
Catarina Oliveira Miranda, Carla Andreia Teixeira, Vera Filipe Sousa, Telma Emanuela Santos, Márcia Almeida Liz, Ana Maio Marques, Perpétua Pinto-Do-Ó, Mónica Mendes Sousa   +7 more
doaj   +1 more source

Identification of novel gene signatures and immune cell infiltration in intervertebral disc degeneration using bioinformatics analysis

Frontiers in Molecular Biosciences, 2023
Background: Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, and an overall understanding of the molecular mechanisms related to IDD is still lacking. The purpose of this study was to explore gene signatures and immune cell
Tao Tang, Tao Tang, Zhongyuan He, Zhongyuan He, Zhengya Zhu, Fuan Wang, Fuan Wang, Hongkun Chen, Fu Zhang, Jiaxiang Zhou, Jianmin Wang, Baoliang Li, Baoliang Li, Xizhe Liu, Zhiyu Zhou, Zhiyu Zhou, Shaoyu Liu, Shaoyu Liu   +17 more
doaj   +1 more source

Advances and Pitfalls of Cell Therapy in Metabolic Leukodystrophies

Cell Transplantation, 2013
Leukodystrophies are a group of disorders characterized by myelin dysfunction, either at the level of myelin formation or maintenance, that affect the central nervous system (CNS) and also in some cases, to a lesser extent, the peripheral nervous system (
Catarina Oliveira Miranda, Pedro Brites, Mónica Mendes Sousa, Carla Andreia Teixeira   +3 more
doaj   +1 more source