Results 11 to 20 of about 17,599 (272)

The Time Course of MHC-I Expression in C57BL/6J and A/J Mice Correlates with the Degree of Retrograde Gliosis in the Spinal Cord following Sciatic Nerve Crush

Cells, 2022
The pleiotropic role of the major histocompatibility complex class I (MHC-I) reflects the close association between the nervous and immune systems. In turn, MHC-I upregulation postinjury is associated with a better regenerative outcome in isogenic mice ...
Bruno Henrique de Melo Lima, André Luis Bombeiro, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira   +3 more
doaj   +1 more source

The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022
Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee, Graeme S. V. McDowell, Darryl C. De Vivo, Daniel Friedman, Samuel F. Berkovic, Maria Spanou, Argirios Dinopoulos, Katheryn Grand, Pedro A. Sanchez‐Lara, Michelle Allen‐Sharpley, Jodi Warman‐Chardon, Alexander Solyom, Thierry Levade, Edward H. Schuchman, Steffany A. L. Bennett, David A. Dyment, Toni S. Pearson   +16 more
wiley   +1 more source

HDAC-6 inhibition ameliorates the early neuropathology in a mouse model of Krabbe disease

Frontiers in Molecular Neuroscience, 2023
IntroductionIn Krabbe disease (KD), mutations in β-galactosylceramidase (GALC), a lysosomal enzyme responsible for the catabolism of galactolipids, leads to the accumulation of its substrates galactocerebroside and psychosine.
Sandra O. Braz, Marlene M. Morgado, Marta I. Pereira, Ana C. Monteiro, Olga Golonzhka, Matthew Jarpe, Pedro Brites, Monica M. Sousa, Joana Nogueira-Rodrigues   +8 more
doaj   +1 more source

Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration

Nanotechnology Reviews, 2021
Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration.
Gu Xinyi, Chen Xiaoli, Tang Xiaoxuan, Zhou Zhihao, Huang Tingting, Yang Yumin, Ling Jue   +6 more
doaj   +1 more source

Biomechanical Properties of Bionic Collum Femoris Preserving Hip Prosthesis: A Finite Element Analysis

Orthopaedic Surgery, 2023
Objective Compared with total hip replacement, conventional collum femoris preserving prosthesis has a better bone retention effect. However, damage to the trabecular bone of the proximal femur leads to inevitable abnormal stress distribution, which ...
Xiaomeng Zhang, Yanhua Wang, Lijia Zhang, Kai Yu, Zhentao Ding, Yichong Zhang, Xiaofeng Chen, Chen Xiong, Yun Ji, Dianying Zhang, Xinlong Ma   +10 more
doaj   +1 more source

Comparative intra- and inter-observer reliability of two methods for evaluating intraoperative ultrasonography-based spinal cord hyperechogenicity intensity in degenerative cervical myelopathy

BMC Musculoskeletal Disorders, 2022
Objectives During French-door laminoplasty, a linear array transducer of IOUS was used to observe and record the spinal cord decompression. To acquire a higher-reliability method, and compare the in-observer and inter-observer reliability of two methods ...
Huachuan Wu, Guoliang Chen, Xianlong Li, Zhengya Zhu, Zuofeng Xu, Xizhe Liu, Shaoyu Liu   +6 more
doaj   +1 more source

Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation

Frontiers in Bioengineering and Biotechnology, 2022
Activation of mitophagy was considered to be a potential therapeutic strategy for intervertebral disc degeneration (IDD). There was evidence suggesting that hyaluronic acid (HA) can protect mitochondria from oxidative stress in chondrocytes, but its ...
Fu Zhang, Fu Zhang, Songjuan Wang, Manman Gao, Baoliang Li, Zhongyuan He, Tao Tang, Zhengya Zhu, Shaoyu Liu, Shaoyu Liu, Zhiyu Zhou, Zhiyu Zhou   +11 more
doaj   +1 more source

Identification of novel gene signatures and immune cell infiltration in intervertebral disc degeneration using bioinformatics analysis

Frontiers in Molecular Biosciences, 2023
Background: Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, and an overall understanding of the molecular mechanisms related to IDD is still lacking. The purpose of this study was to explore gene signatures and immune cell
Tao Tang, Tao Tang, Zhongyuan He, Zhongyuan He, Zhengya Zhu, Fuan Wang, Fuan Wang, Hongkun Chen, Fu Zhang, Jiaxiang Zhou, Jianmin Wang, Baoliang Li, Baoliang Li, Xizhe Liu, Zhiyu Zhou, Zhiyu Zhou, Shaoyu Liu, Shaoyu Liu   +17 more
doaj   +1 more source

The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter

Cell Reports, 2016
The actin-binding protein adducin was recently identified as a component of the neuronal subcortical cytoskeleton. Here, we analyzed mice lacking adducin to uncover the function of this protein in actin rings.
Sérgio Carvalho Leite, Paula Sampaio, Vera Filipe Sousa, Joana Nogueira-Rodrigues, Rita Pinto-Costa, Luanne Laurel Peters, Pedro Brites, Mónica Mendes Sousa   +7 more
doaj   +1 more source

Primary Bone Marrow Mesenchymal Stromal Cells Rescue the Axonal Phenotype of Twitcher Mice

Cell Transplantation, 2014
Krabbe's disease (KD) is a demyelinating disorder caused by the deficiency of lysosomal galactocerebrosi-dase (GALC), affecting both the central (CNS) and the peripheral nervous system (PNS).
Catarina Oliveira Miranda, Carla Andreia Teixeira, Vera Filipe Sousa, Telma Emanuela Santos, Márcia Almeida Liz, Ana Maio Marques, Perpétua Pinto-Do-Ó, Mónica Mendes Sousa   +7 more
doaj   +1 more source