Results 21 to 30 of about 1,438,567 (364)
Theranostics, 2020 Rationale: Autophagy in Schwann cells (SCs) is crucial for myelin debris degradation and clearance following peripheral nerve injury (PNI). Nerve growth factor (NGF) plays an important role in reconstructing peripheral nerve fibers and promoting axonal ...
Rui Li +14 more
semanticscholar +1 more source
Tissue Engineering Strategies for Peripheral Nerve Regeneration
Frontiers in Neurology, 2021 A peripheral nerve injury (PNI) has severe and profound effects on the life of a patient. The therapeutic approach remains one of the most challenging clinical problems.
Yin Li +8 more
semanticscholar +1 more source
Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation
Frontiers in Bioengineering and Biotechnology, 2022 Activation of mitophagy was considered to be a potential therapeutic strategy for intervertebral disc degeneration (IDD). There was evidence suggesting that hyaluronic acid (HA) can protect mitochondria from oxidative stress in chondrocytes, but its ...
Fu Zhang +11 more
doaj +1 more source
The interaction of stem cells and vascularity in peripheral nerve regeneration
Neural Regeneration Research, 2021 The degree of nerve regeneration after peripheral nerve injury can be altered by the microenvironment at the site of injury. Stem cells and vascularity are postulated to be a part of a complex pathway that enhances peripheral nerve regeneration; however,
S. Saffari +4 more
semanticscholar +1 more source
The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter
Cell Reports, 2016 The actin-binding protein adducin was recently identified as a component of the neuronal subcortical cytoskeleton. Here, we analyzed mice lacking adducin to uncover the function of this protein in actin rings.
Sérgio Carvalho Leite +7 more
doaj +1 more source
Acta Pharmacologica Sinica, 2020 Peripheral nerve injury (PNI), one of the most common concerns following trauma, can result in a significant loss of sensory or motor function. Restoration of the injured nerves requires a complex cellular and molecular response to rebuild the functional
Rui Li +5 more
semanticscholar +1 more source
Peripheral Nerve Regeneration and Muscle Reinnervation
International Journal of Molecular Sciences, 2020 Injured peripheral nerves but not central nerves have the capacity to regenerate and reinnervate their target organs. After the two most severe peripheral nerve injuries of six types, crush and transection injuries, nerve fibers distal to the injury site
T. Gordon
semanticscholar +1 more source
Frontiers in Molecular Biosciences, 2023 Background: Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, and an overall understanding of the molecular mechanisms related to IDD is still lacking. The purpose of this study was to explore gene signatures and immune cell
Tao Tang +17 more
doaj +1 more source
Primary Bone Marrow Mesenchymal Stromal Cells Rescue the Axonal Phenotype of Twitcher Mice
Cell Transplantation, 2014 Krabbe's disease (KD) is a demyelinating disorder caused by the deficiency of lysosomal galactocerebrosi-dase (GALC), affecting both the central (CNS) and the peripheral nervous system (PNS).
Catarina Oliveira Miranda +7 more
doaj +1 more source
Advances and Pitfalls of Cell Therapy in Metabolic Leukodystrophies
Cell Transplantation, 2013 Leukodystrophies are a group of disorders characterized by myelin dysfunction, either at the level of myelin formation or maintenance, that affect the central nervous system (CNS) and also in some cases, to a lesser extent, the peripheral nervous system (
Catarina Oliveira Miranda +3 more
doaj +1 more source