Results 81 to 90 of about 1,438,567 (364)

The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction

eLife, 2020
Neurons have a membrane periodic skeleton (MPS) composed of actin rings interconnected by spectrin. Here, combining chemical and genetic gain- and loss-of-function assays, we show that in rat hippocampal neurons the MPS is an actomyosin network that ...
Ana Rita Costa, Sara C Sousa, Rita Pinto-Costa, José C Mateus, Cátia DF Lopes, Ana Catarina Costa, David Rosa, Diana Machado, Luis Pajuelo, Xuewei Wang, Feng-quan Zhou, António J Pereira, Paula Sampaio, Boris Y Rubinstein, Inês Mendes Pinto, Marko Lampe, Paulo Aguiar, Monica M Sousa   +17 more
doaj   +1 more source

Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration

Nature Communications, 2018
Critical functions of intra-axonally synthesized proteins are thought to depend on regulated recruitment of mRNA from storage depots in axons. Here we show that axotomy of mammalian neurons induces translation of stored axonal mRNAs via regulation of the
Pabitra K Sahoo, S. J. Lee, Poonam B Jaiswal, Stefanie Alber, Amar N. Kar, Sharmina Miller-Randolph, Elizabeth E. Taylor, Terika P. Smith, Bhagat Singh, T. Ho, A. Urisman, S. Chand, Edsel A. Peña, A. Burlingame, C. Woolf, M. Fainzilber, A. English, J. Twiss   +17 more
semanticscholar   +1 more source

REGENERATION OF PERIPHERAL NERVES [PDF]

The Journal OF Nervous and Mental Disease, 1922
n ...
openaire   +2 more sources

Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations

Advanced Functional Materials, EarlyView.
Highly selective chemistries are required for fabrication and post‐cross–linking modification of cell‐encapsulating hydrogels used in tissue engineering applications. Isonitrile ligation reactions represent a promising class of bioorthogonal chemistries for engineering hydrogel‐based cellular microenvironments. Isonitrile‐based hydrogels are stable and
Ping Zhou, Lauren Brown, Christopher M. Madl   +2 more
wiley   +1 more source

Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc

JOR Spine
Background Disc degeneration is associated with repetitive violent injuries. This study aims to explore the impact of repetitive strikes loading on the biology and biomechanics of intervertebral discs (IVDs) using an organ culture model.
Jiaxiang Zhou, Jianmin Wang, Jianfeng Li, Zhengya Zhu, Zhongyuan He, Junhong Li, Tao Tang, Hongkun Chen, Yukun Du, Zhen Li, Manman Gao, Zhiyu Zhou, Yongming Xi   +12 more
doaj   +1 more source

Gingiva-Derived Mesenchymal Stem Cell-Extracellular Vesicles Activate Schwann Cell Repair Phenotype and Promote Nerve Regeneration

Tissue Engineering. Part A, 2019
A fully functional recovery of peripheral nerve injury remains a major challenge and an unmet clinical need. Recent evidence has reported promising therapeutic effects of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) in experimental ...
Qin Mao, P. Nguyen, R. Shanti, S. Shi, Pasha Shakoori, Qunzhou Zhang, A. Le   +6 more
semanticscholar   +1 more source

Photothermal Hydrogel with Mn3O4 Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism

Advanced Functional Materials, EarlyView.
The MPTT‐nanozyme‐hydrogel system (Mn3O4@ChS‐HA) provides a multifunctional therapeutic strategy for intervertebral disc degeneration (IVDD), effectively targeting oxidative stress and enhancing AF repair by restoring extracellular matrix (ECM) and redox homeostasis.
Yangyang Chen, Chan Xue, Feifei Ni, Binwu Hu, Miaoheng Yan, He Zhang, Yuxiang Hu, Xiaoyao Peng, Guangfang Li, Yu Han, Hongjian Liu, Zengwu Shao, Qin Wang, Yulong Wei   +13 more
wiley   +1 more source

Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge

Glia, 2020
Schwann cells within the peripheral nervous system possess a remarkable regenerative potential. Current research shows that peripheral nerve‐associated Schwann cells possess the capacity to promote repair of multiple tissues including peripheral nerve ...
Qing Min, D. Parkinson, X. Dun
semanticscholar   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Spinal hypermobility accelerates ossification in posterior longitudinal ligaments: insights from an in vivo mouse model

Frontiers in Physiology
IntroductionOssification of the posterior longitudinal ligaments (OPLL) is characterized by heterotopic ossification in the posterior longitudinal ligament of spine.
Tao Tang, Tao Tang, Zhengya Zhu, Zhengya Zhu, Zhongyuan He, Zhongyuan He, Fuan Wang, Lin Chen, Jianfeng Li, Hongkun Chen, Jiaxiang Zhou, Jianmin Wang, Shaoyu Liu, Yunfeng Yao, Xizhe Liu, Zhiyu Zhou   +15 more
doaj   +1 more source