Results 41 to 50 of about 2,609,487 (361)

The effect of biologically active compounds in the mucus of slugs Limax maximus and Arion rufus on human skin cells

open access: yesScientific Reports, 2021
Molluscs are one of the sources of biologically active substances, which are now intensively studied, especially for their anti-cancer properties. Malignant melanoma originates from melanocytes, develops very quickly and is associated with poor prognosis.
Leśków Anna   +3 more
doaj   +1 more source

Immunophilins in the Nervous System [PDF]

open access: yesNeuron, 1998
Supported by United States Public Health Service grant MH-18501, Research Scientist Award DA-00074 to S. H. S., and Training Grant GM-07309 to M. M. L. and P. E. B. S. H. S. owns stock in and is entitled to royalties from Guilford Pharmaceuticals, which is developing products related to immunophilins.
Michael M. Lai   +2 more
openaire   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Impaired H-Reflex Adaptations Following Slope Walking in Individuals With Post-stroke Hemiparesis [PDF]

open access: yes, 2019
Background and Purpose: Short term adaptations in the Ia afferent-motoneuron pathway, as measured using the H-reflex, in response to altered ground reaction forces (GRFs) applied at the feet during slope walking have been observed in the non-impaired ...
Akoopie, Eric   +5 more
core   +2 more sources

The enteric nervous system [PDF]

open access: yesDevelopmental Biology, 2012
The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal tract, consists of numerous types of neurons, and glial cells, that are distributed in two intramuscular plexuses that extend along the entire length of the gut and control co-ordinated smooth muscle contractile activity and other gut functions.
Vassilis Pachnis   +2 more
openaire   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Reversible inhibitor of CRM1 sensitizes glioblastoma cells to radiation by blocking the NF-κB signaling pathway

open access: yesCancer Cell International, 2020
Background Activation of nuclear factor-kappa B (NF-κΒ) through DNA damage is one of the causes of tumor cell resistance to radiotherapy. Chromosome region 1 (CRM1) regulates tumor cell proliferation, drug resistance, and radiation resistance by ...
Xuejiao Liu   +12 more
doaj   +1 more source

Region-specific remodeling of the enteric nervous system and enteroendocrine cells in the colon of spinal cord injury patients

open access: yesScientific Reports, 2023
Patients with spinal cord injury (SCI) suffer from major bowel dysfunction, whose exact pathophysiology, particularly the involvement of the enteric nervous system or epithelial dysfunction is poorly understood.
Chloë Lefèvre   +9 more
doaj   +1 more source

Effect of obesity on autonomic nervous system [PDF]

open access: yes, 2011
The present study was carried out on 100 volunteers of which 50 subjects with BMI > 30kg/m2 were included in study group and 50 subjects with BMI < 30kg/m2 (non obese) were included in control group.
Simran Grewal, Vidushi Gupta, Int J Cur Bio Med Sci.
core  

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