Results 41 to 50 of about 23,851,532 (246)

Region-specific remodeling of the enteric nervous system and enteroendocrine cells in the colon of spinal cord injury patients

Scientific Reports, 2023
Patients with spinal cord injury (SCI) suffer from major bowel dysfunction, whose exact pathophysiology, particularly the involvement of the enteric nervous system or epithelial dysfunction is poorly understood.
Chloë Lefèvre, Camille Le Roy, Anne Bessard, Catherine Le Berre-Scoul, Justine Marchix, Emmanuel Coron, Marc Le Rhun, Charlène Brochard, Brigitte Perrouin-Verbe, Michel Neunlist   +9 more
doaj   +1 more source

Reversible inhibitor of CRM1 sensitizes glioblastoma cells to radiation by blocking the NF-κB signaling pathway

Cancer Cell International, 2020
Background Activation of nuclear factor-kappa B (NF-κΒ) through DNA damage is one of the causes of tumor cell resistance to radiotherapy. Chromosome region 1 (CRM1) regulates tumor cell proliferation, drug resistance, and radiation resistance by ...
Xuejiao Liu, Yiming Tu, Yifeng Wang, Di Zhou, Yulong Chong, Lin Shi, Guanzheng Liu, Xu Zhang, Sijin Wu, Huan Li, Shangfeng Gao, Mingshan Niu, Rutong Yu   +12 more
doaj   +1 more source

A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

Nature Communications, 2023
Glial cells have been proposed as a source of neural progenitors, but the mechanisms underpinning the neurogenic potential of adult glia are not known.
Anna Laddach, Song Hui Chng, Reena Lasrado, Fränze Progatzky, Michael Shapiro, Alek Erickson, Marisol Sampedro Castaneda, Artem V. Artemov, Ana Carina Bon-Frauches, Eleni-Maria Amaniti, Jens Kleinjung, Stefan Boeing, Sila Ultanir, Igor Adameyko, Vassilis Pachnis   +14 more
doaj   +1 more source

THE NERVOUS SYSTEM. [PDF]

The Lancet
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openaire   +2 more sources

The effect of biologically active compounds in the mucus of slugs Limax maximus and Arion rufus on human skin cells

Scientific Reports, 2021
Molluscs are one of the sources of biologically active substances, which are now intensively studied, especially for their anti-cancer properties. Malignant melanoma originates from melanocytes, develops very quickly and is associated with poor prognosis.
Leśków Anna, Tarnowska Małgorzata, Szczuka Izabela, Diakowska Dorota   +3 more
doaj   +1 more source

Engineered oncolytic virus coated with anti-PD-1 and alendronate for ameliorating intratumoral T cell hypofunction

Experimental Hematology & Oncology
Background Glioblastoma is a highly aggressive and devastating primary brain tumor that is resistant to conventional therapies. Oncolytic viruses represent a promising therapeutic approach for glioblastoma by selectively lysing tumor cells and eliciting ...
Yufu Zhu, Xuefeng Zhang, Jiaqi Jin, Xiaoqian Wang, Yang Liu, Jian Gao, Diancheng Hang, Lin Fang, Hengzhu Zhang, Hongmei Liu   +9 more
doaj   +1 more source

The expression of B7-H3 isoforms in newly diagnosed glioblastoma and recurrence and their functional role

Acta Neuropathologica Communications, 2021
Short survival of glioblastoma (GBM) patients is due to systematic tumor recurrence. Our laboratory identified a GBM cell subpopulation able to leave the tumor mass (TM) and invade the subventricular zone (SVZ-GBM cells).
Marina Digregorio, Natacha Coppieters, Arnaud Lombard, Paul Noel Lumapat, Felix Scholtes, Bernard Rogister   +5 more
doaj   +1 more source

Role of EGFR in the Nervous System

Cells, 2020
Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in adult tissues, being involved in growth, differentiation, maintenance and repair ...
R. Romano, C. Bucci
semanticscholar   +1 more source

Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour

Nature Communications, 2016
Behavioural adaptations in response to stress are thought to be regulated by rapid neurotransmitter action, followed by slower hormonal signalling. Here, using optogenetic approaches, the authors find corticotroph cell populations are capable of rapidly ...
Rodrigo J. De Marco, Theresa Thiemann, Antonia H. Groneberg, Ulrich Herget, Soojin Ryu   +4 more
doaj   +1 more source

Cognitive impairments in patients with prior ischemic stroke

Неврология, нейропсихиатрия, психосоматика, 2014
The authors give the data available in the literature on and the results of their studies of the epidemiology, risk factors, pathogenesis, diagnosis, and treatment of poststroke cognitive impairment (PSCI).
V. A. Parfenov, M. A. Cherdak, N. V. Vakhnina, S. V. Verbitskaya, L. Yu. Nikitina   +4 more
doaj   +1 more source