Results 131 to 140 of about 41,897 (208)

Quality Thresholds for Angiogenesis Under Acoustic Manipulation in Engineered Vascular Tissues

Advanced Science, Volume 13, Issue 52, 18 September 2026.
Defined biological and physical quality thresholds achieved through acoustic manipulation regulate cellular alignment and spatial organization, promoting self‐assembling vasculature, extracellular matrix deposition, and angiogenic responses, thereby establishing critical acoustic patterning requirements for engineered vascular tissue development in ...
Oscar O'Dwyer Lancaster‐Jones, Russell Quinn, Niloofar Khoshdel Rad, Kilian Paul, Andrea Frank, Daniela F. Duarte Campos   +5 more
wiley   +1 more source

Variants in the nestin gene and coronary heart disease

, 2008
Background. The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques.
Hughes, Anne, McKeown, Pascal P., Patterson, Chris C., Belton, Christine, Meng, Weihua   +4 more
core   +1 more source

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, Volume 13, Issue 52, 18 September 2026.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun, Biyu Yang, Hanyuan Zheng, Qi Wang, Yajiao Shi, Gandig Wang, Wang Yin, Hui Wang, Xuetao Qi, Yun Yao, Jiaxin Wang, Shuang Cui, Kun Cui, Jian Mao, Yiyuan Xia, Jianwen Deng, Siyuan Zhao, Zhihao Wang, Fengyu Liu, Ming Yi, Jiuyang Ding, Weidong Le, Xinyan Li, Junliang Yuan, You Wan, Jie Zheng   +25 more
wiley   +1 more source

Nestin serves as a prosurvival determinant that links to the cytoprotective effect of epidermal growth factor in rat vascular smooth muscle cells

, 2012
[[abstract]]Nestin is an intermediate filament protein mainly expressed in muscle and neural progenitors. Recently, we reported that nestin is expressed in rat vascular smooth muscle cells (VSMCs), disappears after serum-deprivation and then is re ...
黃元勵;Huang, Yuan-Li
core  

RETRACTED: Nestin Regulates Autophagy‐Dependent Ferroptosis Mediated Skeletal Muscle Atrophy by Ubiquitinating MAP 1LC3B

Journal of Cachexia, Sarcopenia and Muscle
Background Programmed cell death plays a critical role in skeletal muscle atrophy. Ferroptosis, an iron‐dependent form of programmed cell death driven by lipid peroxidation, has been implicated in various diseases, but its role in skeletal muscle atrophy
Shunshun Han, Xiyu Zhao, Chunlin Yu, Can Cui, Yao Zhang, Qing Zhu, Mohan Qiu, Chaowu Yang, Huadong Yin   +8 more
doaj   +1 more source

Inhibition of METTL14 Alleviates OGD/R‐Induced Neuronal Differentiation Injury in Neural Stem Cells Through Suppressing the Tp53inp2/Ptgs2 Axis: Potential Benefits for the Mouse MCAO Model

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
The graphical abstract highlights that ischemic stroke leads to increased METTL14 expression, which enhances Tp53inp2 mRNA stability through m6A modification. Elevated Tp53inp2 then promotes damaging mitophagy and ROS production by upregulating Ptgs2, ultimately impairing the neuronal differentiation of neural stem cells.
Dan Hou, Yujie Hu, Tian Yun, Dan Yu, Guoshuai Yang   +4 more
wiley   +1 more source

PPARγ‐Dependent Pioglitazone Treatment Suppresses Neuroinflammation and Improves Cognition in Sepsis‐Associated Encephalopathy in Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Pioglitazone alleviated CLP‐induced sepsis‐associated encephalopathy in mice by activating PPAR‐γ, improving survival, learning, and memory, and anxiety‐like behavior. It also protected the BBB, suppressed TLR4/NF‐κB‐associated inflammation, and reduced neuronal apoptosis, effects largely reversed by GW9662.
Jing Zhang, Peng Wang, Nan Li, Yan Gao
wiley   +1 more source

Navigating Human Astrocyte Differentiation: Direct and Rapid One‐Step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network Development

Glia, Volume 74, Issue 9, September 2026.
One‐step protocol enabling direct differentiation of human iPSCs into functional astrocytes within 5 weeks. Validated in > 60 lines across 10 labs. iPSC‐astrocytes support robust neuronal network development in co‐culture. ABSTRACT Astrocytes play a pivotal role in neuronal network development.
Imke M. E. Schuurmans, Annika Mordelt, Marta Guevara‐Ferrer, Katrin Linda, Denise Duineveld, Sofia Puvogel, Marina P. Hommersom, Nicky Scheefhals, Lisa Rahm, Emma Dyke, Gijs‐Jan Scholten, Caroline Knorz, Carlos Gonzalez Jimenez, Noelle van Egmond, Astrid Oudakker, Chantal Bijnagte‐Schoenmaker, Hans van Bokhoven, Wei Wei, Samuel Hofmann, Sabine Jung‐Klawitter, Sandra Mojica‐Perez, Jack Parent, Lidia Carotenuto, Sarah Weckhuysen, Nadine Maas, Ype Elgersma, Eline van de Ven, Dirk Lefeber, Anita Lygeroudi, Helga E. de Vries, Luc Jordi, Magdalini Polymenidou, Teresa Mitchell‐Garcia, Iulia Dragan, Amalia Dolga, Lot D. de Witte, Clara D. M. van Karnebeek, James Ellis, Alejandro Garanto, Nael Nadif Kasri   +39 more
wiley   +1 more source

Nestin : filament formation and expression in myogenesis and muscle disorders

, 1997
Intermediate filaments (IF), together with microfilaments and microtubules, are the major components of the cytoskeleton of eukaryotic cells. In myogenic cells three IF proteins are expressed; desmin, vimentin and nestin.
Gunnar Sjöberg (6386474)
core   +1 more source