Results 91 to 100 of about 19,431 (234)

Transcriptional firing helps to drive NETosis

Scientific Reports, 2017
AbstractNeutrophils are short-lived innate immune cells. These cells respond quickly to stimuli, and die within minutes to hours; the relevance of DNA transcription in dying neutrophils remains an enigma for several decades. Here we show that the transcriptional activity reflects the degree of DNA decondensation occurring in both NADPH oxidase 2 (Nox ...
Meraj A. Khan, Nades Palaniyar
openaire   +2 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease [PDF]

, 2017
BACKGROUND: Neutrophil extracellular traps (NETs) have been observed in the airway in COPD, but their clinical and pathophysiological implications have not been defined.OBJECTIVE: To determine if NETs are associated with disease severity in COPD, and how
Agusti, Alison J. Dicker, Andrew J. Cassidy, Bafadhel, Branzk, Brinkmann, Calverley, Caporaso, Caudrillier, Celli, Christopher J. Fong, Colin N.A. Palmer, Dickson, Donnelly, Dworski, Eleanor G. Pumphrey, Elizabeth Furrie, Farnworth, Flynn, Gill Brady, Gisli G. Einarsson, Grabcanovic-Musija, Gray, Greenwood, Guillermo Suarez-Cuartin, Haslett, Hoenderdos, J. Stuart Elborn, James D. Chalmers, Jiang, Juneau, Kessenbrock, Khandpur, Knight, Lange, Leidy, Lozano, Megan L. Crichton, Menegazzi, Metzler, Morris, Obermayer, Oriol Sibila, Papayannopoulos, Pascoe, Pavord, Pedersen, Richens, Sara E. Marshall, Savill, Sayah, Short, Speizer, Stuart Schembri, Vestbo, Wasyla Ibrahim, Willemse, Yipp, Zabieglo   +58 more
core   +2 more sources

NETosis in Surgery

Annals of Surgery
Objective: To provide surgeons with an understanding of the latest research on NETosis, including the pathophysiology and treatment of conditions involving neutrophil extracellular traps (NETs) in the care of surgical patients.
James, Philippa, Kaushal, Devesh, Beaumont Wilson, Robert   +2 more
openaire   +2 more sources

A large‐scale single‐cell transcriptomic atlas indicates the immune panorama of influenza A infection

iMeta, EarlyView.
The study presents a large‐scale single‐cell transcriptomic atlas profiling over 612,010 peripheral immune cells from 97 individuals to decode the heterogeneity of influenza infection. These findings indicate a fundamental immune dichotomy determining clinical trajectories: a protective, monocyte‐centric antiviral state in mild disease versus a ...
Yi Wang, Shuzi Liu, Laurence Don Wai Luu, Yongzhi Zhai, Chenliang Zhu, Zhaomin Feng, Yao Tan, Linglong Wan, Jie Wang, Juan Zhou, Jing Wang, Lixin Xie, Quanyi Wang, Fei Xie   +13 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases [PDF]

, 2017
textabstractThe classical paradigm of tuberculosis (TB) immunity, with a central protective role for Th1 responses and IFN-γ-stimulated cellular responses, has been challenged by unsatisfactory results of vaccine strategies aimed at enhancing Th1 ...
Abhimanyu, Achkar, Afshar, Amarilyo, Ambrosi, Andersson, Antonelli, Arnason, Asano, Ashenafi, Askenase, Avci, Axtell, Axtell, Babudieri, Baccala, Bach, Baechler, Bafica, Bandaru, Barber, Barnes, Basile, Basile, Behar, Belkahla, Bennett, Benson, Berclaz, Berry, Bjornsdottir, Blanco, Blanco, Blomgran, Boer, Boniface, Boum, Braian, Brkic, Brkic, Brkic, Bulat-Kardum, Caccamo, Campbell, Canavan, Carmona-Rivera, Chen, Chen, Choi, Cliff, Cohen, Colditz, Collins, Conrady, Cooper, Coquery, Correa, Coscolla, Cowan, Craft, Crouse, Crow, Crow, Croxford, Cruz, Cunningham, Dalod, de Bruin, de Jong, de Paus, Decker, Demers, Deng, Desvignes, Dey, Di Paolo, Divangahi, Dolff, Dorhoi, Doz, Dragon, Du, Edwards, El-Behi, Elkayam, Elkington, Eruslanov, Eshleman, Eum, Fairweather, Farah, Farkas, Fejer, Feng, Fischer, Fleetwood, Francis, Francois, Freches, Fremond, Gagliani, Ganguly, Garcia-Romo, Gautier, Giosue, Giosue, Godfrey, Gonzalez-Juarrero, Gopal, Gopal, Gopal, Goriely, Goriely, Grainger, Griffin, Grogan, Grosset, Guarda, Guardigni, Guenova, Hedlund, Heidarnezhad, Higgins, Higgs, Hochrein, Hoeksema, Hoeve, Houben, Huebener, Hwang, Ifergan, Ireland, Ivashkiv, Jacob, Jayaraman, Jiao, Jin, Jones, Jones, Joosten, Joosten, Jurado, Kalinski, Kaminskaia, Kara, Kearney, Keller, Khader, Khader, Kim, Kim, Kirou, Kisich, Klose, Knaul, Kolb-Maurer, Korn, Kumar, Lande, Langrish, Langrish, Lazar-Molnar, Lazarus, Li, Liang, Lichtner, Lienard, Lindau, Linterman, Litinskiy, Liu, Lockhart, Longhi, Lood, Lopez, Lozza, Lu, Luan, Lubberts, Lyadova, Lyadova, Lyakh, MacKenzie, Maertzdorf, Maione, Manca, Manca, Manni, Manry, Mansoori, Manzanillo, Mao, Marin, Marin, Mariotti, Martin, Matsuoka, Mayer-Barber, Mayer-Barber, McNab, McNab, McNab, Merrill, Metcalfe, Midgley, Milano, Mishra, Mobley, Moguche, Monin, Mourik, Mueller, Munari, Mvubu, Nakayamada, Nandi, Napolitani, Navarra, Ndiaye, Ng, Niewold, Noster, Novikov, Nunnari, Okada, Okamoto Yoshida, Olobo, Ordway, Ottenhoff, O’Garra, Pai, Palmero, Pandey, Parkes, Parsa, Paulson, Peng, Perreau, Pers, Persson, Puthia, Rahman, Ramos-Kichik, Rangel Moreno, Rangel-Moreno, Raphael, Rasouli, Reboldi, Redford, Remoli, Repasy, Roberts, Ronnblom, Ronnblom, Roses, Rothchild, Rottenberg, Rovin, Russell, Sabbatani, Sage, Saiga, Sakai, Saraav, Sargentini, Scaffidi, Scapini, Schett, Schiffer, Schlitzer, Schreiber, Schreiber, Scordo, Scriba, Serezani, Shah, Shaler, Shapira, Shen, Shi, Shiomi, Shishikura, Shu, Sierra-Filardi, Silverpil, Simpson, Singh, Sjostrand, Slight, Sorgi, Spits, Stanley, Stephen-Victor, Stifter, Stohl, Strachan, Sutton, Swiecki, Szczucinski, Szeliga, Tada, Tall, Tameris, Teles, Telesca, Terawaki, Thien, Tian, Tian, Toossi, Torrado, Toubi, Trentini, Trinchieri, Tsai, Tsiganov, Tully, Ueno, Ulrichs, Umemura, Une, van Meijgaarden, van Nieuwenhuijze, Verreck, Verreck, Vincent, Vogt, von Scheidt, Wahren-Herlenius, Wang, Wassermann, Watson, Wilson, Wolf, Wong, Xu, Yamazaki, Yeremeev, Yoshimura, Zak, Zarogoulidis, Zhang, Zhang, Zhou, Zhou, Zitvogel, Zizzo, Zollars   +347 more
core   +4 more sources

Deubiquitinase USP7 Regulates Neutrophil Extracellular Trap Formation and Inflammation in Lipopolysaccharide‐Treated Mice Through ICAM‐1 Expression

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis is typified by organ failure due to an unchecked host reaction to infection. This study aims to explore the mechanism of ubiquitin‐specific peptidase 7 (USP7) in sepsis with the involvement of intercellular adhesion molecule‐1 (ICAM‐1).
Hui Xu, Qi Wang, Jing‐Xian Fan, Yong‐Fu Xu, Jiao Yu   +4 more
wiley   +1 more source

Neutrophil extracellular traps [PDF]

, 2013
Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-
Demers, Mélanie, Wagner, Denisa D.
core   +1 more source

The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo

Acta Diabetologica, 2018
Diabetes is associated with an excess release of neutrophil extracellular traps (NETs) and an enhanced NETosis, a neutrophil cell death programme instrumental to anti-microbial defences, but also involved in tissue damage. We herein investigated whether the antidiabetic drug metformin protects against NETosis.We measured NET components in the plasma of
Menegazzo, Lisa, Scattolini, Valentina, Cappellari, Roberta, Bonora, Benedetta Maria, Albiero, Mattia, Bortolozzi, Mario, Romanato, Filippo, Ceolotto, Giulio, Vigili de Kreutzeberg, Saula, Avogaro, Angelo, Fadini, Gian Paolo   +10 more
openaire   +4 more sources