Results 91 to 100 of about 18,973 (244)

Deubiquitinase USP7 Regulates Neutrophil Extracellular Trap Formation and Inflammation in Lipopolysaccharide‐Treated Mice Through ICAM‐1 Expression

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis is typified by organ failure due to an unchecked host reaction to infection. This study aims to explore the mechanism of ubiquitin‐specific peptidase 7 (USP7) in sepsis with the involvement of intercellular adhesion molecule‐1 (ICAM‐1).
Hui Xu, Qi Wang, Jing‐Xian Fan, Yong‐Fu Xu, Jiao Yu   +4 more
wiley   +1 more source

Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases [PDF]

, 2017
textabstractThe classical paradigm of tuberculosis (TB) immunity, with a central protective role for Th1 responses and IFN-γ-stimulated cellular responses, has been challenged by unsatisfactory results of vaccine strategies aimed at enhancing Th1 ...
Abhimanyu, Achkar, Afshar, Amarilyo, Ambrosi, Andersson, Antonelli, Arnason, Asano, Ashenafi, Askenase, Avci, Axtell, Axtell, Babudieri, Baccala, Bach, Baechler, Bafica, Bandaru, Barber, Barnes, Basile, Basile, Behar, Belkahla, Bennett, Benson, Berclaz, Berry, Bjornsdottir, Blanco, Blanco, Blomgran, Boer, Boniface, Boum, Braian, Brkic, Brkic, Brkic, Bulat-Kardum, Caccamo, Campbell, Canavan, Carmona-Rivera, Chen, Chen, Choi, Cliff, Cohen, Colditz, Collins, Conrady, Cooper, Coquery, Correa, Coscolla, Cowan, Craft, Crouse, Crow, Crow, Croxford, Cruz, Cunningham, Dalod, de Bruin, de Jong, de Paus, Decker, Demers, Deng, Desvignes, Dey, Di Paolo, Divangahi, Dolff, Dorhoi, Doz, Dragon, Du, Edwards, El-Behi, Elkayam, Elkington, Eruslanov, Eshleman, Eum, Fairweather, Farah, Farkas, Fejer, Feng, Fischer, Fleetwood, Francis, Francois, Freches, Fremond, Gagliani, Ganguly, Garcia-Romo, Gautier, Giosue, Giosue, Godfrey, Gonzalez-Juarrero, Gopal, Gopal, Gopal, Goriely, Goriely, Grainger, Griffin, Grogan, Grosset, Guarda, Guardigni, Guenova, Hedlund, Heidarnezhad, Higgins, Higgs, Hochrein, Hoeksema, Hoeve, Houben, Huebener, Hwang, Ifergan, Ireland, Ivashkiv, Jacob, Jayaraman, Jiao, Jin, Jones, Jones, Joosten, Joosten, Jurado, Kalinski, Kaminskaia, Kara, Kearney, Keller, Khader, Khader, Kim, Kim, Kirou, Kisich, Klose, Knaul, Kolb-Maurer, Korn, Kumar, Lande, Langrish, Langrish, Lazar-Molnar, Lazarus, Li, Liang, Lichtner, Lienard, Lindau, Linterman, Litinskiy, Liu, Lockhart, Longhi, Lood, Lopez, Lozza, Lu, Luan, Lubberts, Lyadova, Lyadova, Lyakh, MacKenzie, Maertzdorf, Maione, Manca, Manca, Manni, Manry, Mansoori, Manzanillo, Mao, Marin, Marin, Mariotti, Martin, Matsuoka, Mayer-Barber, Mayer-Barber, McNab, McNab, McNab, Merrill, Metcalfe, Midgley, Milano, Mishra, Mobley, Moguche, Monin, Mourik, Mueller, Munari, Mvubu, Nakayamada, Nandi, Napolitani, Navarra, Ndiaye, Ng, Niewold, Noster, Novikov, Nunnari, Okada, Okamoto Yoshida, Olobo, Ordway, Ottenhoff, O’Garra, Pai, Palmero, Pandey, Parkes, Parsa, Paulson, Peng, Perreau, Pers, Persson, Puthia, Rahman, Ramos-Kichik, Rangel Moreno, Rangel-Moreno, Raphael, Rasouli, Reboldi, Redford, Remoli, Repasy, Roberts, Ronnblom, Ronnblom, Roses, Rothchild, Rottenberg, Rovin, Russell, Sabbatani, Sage, Saiga, Sakai, Saraav, Sargentini, Scaffidi, Scapini, Schett, Schiffer, Schlitzer, Schreiber, Schreiber, Scordo, Scriba, Serezani, Shah, Shaler, Shapira, Shen, Shi, Shiomi, Shishikura, Shu, Sierra-Filardi, Silverpil, Simpson, Singh, Sjostrand, Slight, Sorgi, Spits, Stanley, Stephen-Victor, Stifter, Stohl, Strachan, Sutton, Swiecki, Szczucinski, Szeliga, Tada, Tall, Tameris, Teles, Telesca, Terawaki, Thien, Tian, Tian, Toossi, Torrado, Toubi, Trentini, Trinchieri, Tsai, Tsiganov, Tully, Ueno, Ulrichs, Umemura, Une, van Meijgaarden, van Nieuwenhuijze, Verreck, Verreck, Vincent, Vogt, von Scheidt, Wahren-Herlenius, Wang, Wassermann, Watson, Wilson, Wolf, Wong, Xu, Yamazaki, Yeremeev, Yoshimura, Zak, Zarogoulidis, Zhang, Zhang, Zhou, Zhou, Zitvogel, Zizzo, Zollars   +347 more
core   +4 more sources

NETosis in Surgery

Annals of Surgery
Objective: To provide surgeons with an understanding of the latest research on NETosis, including the pathophysiology and treatment of conditions involving neutrophil extracellular traps (NETs) in the care of surgical patients.
James, Philippa, Kaushal, Devesh, Beaumont Wilson, Robert   +2 more
openaire   +2 more sources

Mechanism elucidation of cell‐selective fluorescent probes

Smart Molecules, EarlyView.
This perspective outlines five mechanistic strategies—Protein‐oriented, carbohydrate‐oriented, lipid‐oriented, gating‐oriented, and metabolism‐oriented live‐cell distinctions—for achieving cell‐selective fluorescence in live‐cell imaging. By classifying probes based on their interactions with proteins, carbohydrates, lipids, transporters, or metabolic ...
Sourav Sarkar, Young‐Tae Chang
wiley   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

The good and bad of targeting cancer-associated extracellular matrix [PDF]

, 2017
The maintenance of tissue homeostasis requires extracellular matrix (ECM) remodeling. Immune cells actively participate in regenerating damaged tissues contributing to ECM deposition and shaping.
Chiodoni, C., Colombo, M., Sangaletti, S., Tripodo, C.   +3 more
core   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

From patients with arthralgia, pre-RA and recently diagnosed RA: What is the current status of understanding RA pathogenesis? [PDF]

, 2018
It is believed that therapy for rheumatoid arthritis (RA) is the most effective and beneficial within a short time frame around RA diagnosis. This insight has caused a shift from research in patients with established RA to patients at risk of developing ...
Hazes, J.M.W. (Mieke), Lubberts, E.W. (Erik), Molendijk, M. (Marlieke)   +2 more
core   +1 more source

The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo

Acta Diabetologica, 2018
Diabetes is associated with an excess release of neutrophil extracellular traps (NETs) and an enhanced NETosis, a neutrophil cell death programme instrumental to anti-microbial defences, but also involved in tissue damage. We herein investigated whether the antidiabetic drug metformin protects against NETosis.We measured NET components in the plasma of
Menegazzo, Lisa, Scattolini, Valentina, Cappellari, Roberta, Bonora, Benedetta Maria, Albiero, Mattia, Bortolozzi, Mario, Romanato, Filippo, Ceolotto, Giulio, Vigili de Kreutzeberg, Saula, Avogaro, Angelo, Fadini, Gian Paolo   +10 more
openaire   +4 more sources

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes

Clinical &Experimental Allergy, EarlyView.
ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M. F. Wiegman, Aurelie Poli, Joanna Jacków‐Malinowska, Jack Cheeseman, Daniel I. R. Spencer, James McDonnell, James Spicer, Alexandra J. McCraw, Sophia N. Karagiannis   +13 more
wiley   +1 more source