Results 81 to 90 of about 19,431 (234)

Neutrophil‐Mimetic Nanoscavengers Target the Inflammatory Microenvironment to Eliminate NETs/ROS and Immunomodulate cGAS‐STING Signaling in Septic AKI

Advanced Science, EarlyView.
Sepsis‐associated acute kidney injury is driven by oxidative stress, NETs overproduction, and dysregulated innate immunity. Here, we develop neutrophil‐mimetic nanoscavengers that integrate ROS‐scavenging Mn3O4 nanozymes with DNase‐1‐mediated NETs degradation to suppress cGAS‐STING signaling, reprogram macrophage polarization, and effectively alleviate
Zening Zhang, Chenxi Zhang, Ranran Luo, Qiuchi Wu, Pengchen Ren, Xinyu Liu, Yingying Luo, Zhongsheng Xu, Xiaojing He, Yun Liu   +9 more
wiley   +1 more source

Neutrophils in animal models of autoimmune disease [PDF]

, 2016
Neutrophils have traditionally been thought to play only a peripheral role in the genesis of many autoimmune and inflammatory diseases. However, recent studies in a variety of animal models suggest that these cells are central to the initiation and ...
Abram, Ajuebor, Albanesi, Alves, Amaral, Askenasy, Attila Mócsai, Aube, Baik, Barnado, Bento, Binstadt, Braswell, Brinkmann, Buanne, Campbell, Campbell, Carlson, Carneiro-Sampaio, Chan, Chen, Chen, Chen, Chiriac, Christensen, Clifford A. Lowell, Coit, Coquery, Cronstein, Croxford, Cumpelik, Diana, Diana, Ditzel, Dwivedi, Ehrenstein, Elliott, Eyles, Forster, Fournier, Futosi, Gaipl, Garcia, Goldberg, Grayson, Guerreiro-Cacais, Guiducci, Gupta, Hattar, Heimbach, Helms, Henry, Heymann, Hickman, Holden, Huang, Kahlenberg, Kallenberg, Kaplan, Katayama, Kelkka, Kessenbrock, Kim, Kishida, Knight, Knight, Knight, Kovacs, Kuhl, Lamagna, Lande, Li, Lin, Lindwall, Liu, Lood, Maalouf, Maicas, Mancardi, Marciano, Marrakchi, Martinon, Mayadas, McColl, McGonagle, McGonagle, Merrill, Metzler, Metzler, Miller, Milora, Mocsai, Mocsai, Moline-Velazquez, Nemeth, Nesterovitch, O'Shea, Odobasic, Odobasic, Okumura, Ooi, Oswald, Palanichamy, Palmen, Patel, Pfister, Pieterse, Pietronigro, Pietrosimone, Rodrigues-Sousa, Rohrbach, Rumble, Ryckman, Sadik, Samavedam, Sangaletti, Scapini, Scapini, Schauer, Schmidt, Schon, Schon, Schreiber, Schreiber, Schreiber, Shao, Smith, Smith, So, Spengler, Steiger, Steinbach, Sumida, Summers, Tamás Németh, Terkeltaub, Tortola, Ueyama, van der Fits, Vandal, Volmering, Wallace, Walter, Willis, Wipke, Wise, Xiao, Yu, Zehntner, Zenaro, Zhang, Zhang   +151 more
core   +2 more sources

Liver‐Targeted Gallium‐Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy

Advanced Science, EarlyView.
ABSTRACT Acute liver injury (ALI), driven by diverse insults such as drug toxicity and ischemia‐reperfusion, poses a high mortality risk and lacks targeted therapies. While reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and a coordinated cell death pathway PANoptosis have been implicated, their interplay as a unified pathogenic ...
Xiaopeng Cai, Jian He, Jingwen Deng, Ziwei Wang, Zhongshu Wu, Kaiyue Wang, Xiang Zheng, Zhenzhen Gao, Xi Ma, Shumei Wei, Xiangrong Hu, Yuan Ding, Weilin Wang, Min Zhou   +13 more
wiley   +1 more source

Determination of an Interaction Network between an Extracellular Bacterial Pathogen and the Human Host [PDF]

, 2019
A major gap in understanding infectious diseases is the lack of information about molecular interaction networks between pathogens and the human host.
Barnes, Stephen, Fortney, Kate R., Gao, Hongyu, Griesenauer, Brad, Janowicz, Diane M., Johnson, Paula, Liu, Yunlong, Spinola, Stanley M., Tran, Tuan M., Wilson, Landon S.   +9 more
core   +1 more source

Ferroptosis Induction by Fenbendazole Combined With Photothermal Therapy Triggers Dual‐Immunotherapy Against Bladder Cancer

Advanced Science, EarlyView.
The novel intravesical delivery system exhibits GSH‐responsive drug release, enabling a synergistic therapeutic strategy that combines ferroptosis, ICD and PTT. ABSTRACT Ferroptosis, a newly recognized form of regulated cell death, has emerged as a promising strategy in cancer therapy.
Xiaojian Xu, Rui Liang, Anguo Zhao, Jun Zhang, Rongkang Li, Yang Liu, Dashi Deng, Qi Zhuang, Lisha Liu, Lei Peng, Miao Li, Xuedong Wei, Yuhua Huang, Shaohua Zhang, Liang Cheng, Jianquan Hou   +15 more
wiley   +1 more source

NETosis of psoriasis: a critical step in amplifying the inflammatory response

Frontiers in Immunology
NETosis, a regulated form of neutrophil death, is crucial for host defense against pathogens. However, the release of neutrophil extracellular traps (NETs) during NETosis can have detrimental effects on surrounding tissues and contribute to the pro ...
Jinke Zhang, Yahui Feng, Dongmei Shi, Dongmei Shi   +3 more
doaj   +1 more source

Cancer-Associated Thrombosis in Cirrhotic Patients with Hepatocellular Carcinoma. [PDF]

, 2018
It is common knowledge that cancer patients are more prone to develop venous thromboembolic complications (VTE). It is therefore not surprising that patients with hepatocellular carcinoma (HCC) present with a significant risk of VTE, with the portal vein
Burra, P, Campello, E, Russo, Fp., Simioni, P, Spiezia, L, Zanetto, A   +5 more
core   +1 more source

Molecular Stratification of Antiphospholipid Syndrome Through Integrative Analysis of the Whole‐Blood RNA Transcriptome

Arthritis &Rheumatology, EarlyView.
Objective Antiphospholipid syndrome (APS) is a thromboinflammatory disorder characterized by clinical and mechanistic heterogeneity that complicates early diagnosis and hinders targeted treatment. We aimed to identify distinct molecular endotypes among antiphospholipid antibody (aPL)–positive patients using whole‐blood transcriptomics.
Amala Ambati, Feiyang Ma, Katarina Kmetova, Sherwin Navaz, Claire K. Hoy, Cyrus Sarosh, Ajay Tambralli, Erika Navarro‐Mendoza, Johann E. Gudjonsson, J. Michelle Kahlenberg, Jacqueline A. Madison, Alí Duarte‐García, Jason S. Knight, Yu Zuo   +13 more
wiley   +1 more source

A Cooperative Release of Mitochondrial DNA From Platelets and Neutrophils Drives an Interferon Signature in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice [PDF]

, 2019
We report that TLR7, IL-6, and the adaptive immune system are essential for autoimmunity and glomerulonephritis but not for liver pathology in mice expressing the ubiquitin-binding-defective ABIN1[D485N] mutant.
Arthur, J. Simon C., Cohen, Philip, Gierlinski, Marek, Lee, Katherine L., Marchesi, Francesco, Nanda, Sambit Kumar, Petrova, Tsvetana, Rao, Vikram R., Razsolkov, Momchil, Wright, Stephen W.   +9 more
core   +3 more sources