Results 81 to 90 of about 18,973 (244)

NETosis of psoriasis: a critical step in amplifying the inflammatory response

Frontiers in Immunology
NETosis, a regulated form of neutrophil death, is crucial for host defense against pathogens. However, the release of neutrophil extracellular traps (NETs) during NETosis can have detrimental effects on surrounding tissues and contribute to the pro ...
Jinke Zhang, Yahui Feng, Dongmei Shi, Dongmei Shi   +3 more
doaj   +1 more source

Determination of an Interaction Network between an Extracellular Bacterial Pathogen and the Human Host [PDF]

, 2019
A major gap in understanding infectious diseases is the lack of information about molecular interaction networks between pathogens and the human host.
Barnes, Stephen, Fortney, Kate R., Gao, Hongyu, Griesenauer, Brad, Janowicz, Diane M., Johnson, Paula, Liu, Yunlong, Spinola, Stanley M., Tran, Tuan M., Wilson, Landon S.   +9 more
core   +1 more source

Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A. [PDF]

PLoS ONE, 2014
Excessive or aberrant generation of neutrophil extracellular traps (NETs) has recently become implicated in the underlying aetiology of a number of human pathologies including preeclampsia, systemic lupus erythromatosus, rheumatoid arthritis, auto ...
Anurag Kumar Gupta, Stavros Giaglis, Paul Hasler, Sinuhe Hahn   +3 more
doaj   +1 more source

Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice [PDF]

, 2019
We report that TLR7, IL-6, and the adaptive immune system are essential for autoimmunity and glomerulonephritis but not for liver pathology in mice expressing the ubiquitin-binding-defective ABIN1[D485N] mutant.
Arthur, J. Simon C., Cohen, Philip, Gierlinski, Marek, Lee, Katherine L., Marchesi, Francesco, Nanda, Sambit Kumar, Petrova, Tsvetana, Rao, Vikram R., Razsolkov, Momchil, Wright, Stephen W.   +9 more
core   +3 more sources

Post‐surgery level of circulating DNA in stage III colon cancer patients: Impact on the reliability of minimal residual disease detection

International Journal of Cancer, EarlyView.
What's New? Circulating nuclear DNA (cir‐nDNA)‐based assessment of minimal residual disease (MRD) offers powerful post‐surgery prognostic insight for stage III colon cancer (CC). Sparse knowledge of post‐surgical variations and origins in cir‐nDNA, however, has limited its clinical application.
Andrei Kudriavtsev, Saidi Daoud, Catalina Isabel Cofre Muñoz, Alexia Mirandola, Ekaterina Pisareva, Javier Gonzalo Ruiz, Marco Macagno, Nadia Saoudi Gonzalez, Evelyne Crapez, Marc Ychou, Ramon Salazar Soler, Elisabetta Fenocchio, Paula X. Fernandez Calotti, Thibault Mazard, Cristina Santos Vivas, Elena Elez, Federica Di Nicolantonio, Alain R. Thierry   +17 more
wiley   +1 more source

Neutrophils in animal models of autoimmune disease [PDF]

, 2016
Neutrophils have traditionally been thought to play only a peripheral role in the genesis of many autoimmune and inflammatory diseases. However, recent studies in a variety of animal models suggest that these cells are central to the initiation and ...
Abram, Ajuebor, Albanesi, Alves, Amaral, Askenasy, Attila Mócsai, Aube, Baik, Barnado, Bento, Binstadt, Braswell, Brinkmann, Buanne, Campbell, Campbell, Carlson, Carneiro-Sampaio, Chan, Chen, Chen, Chen, Chiriac, Christensen, Clifford A. Lowell, Coit, Coquery, Cronstein, Croxford, Cumpelik, Diana, Diana, Ditzel, Dwivedi, Ehrenstein, Elliott, Eyles, Forster, Fournier, Futosi, Gaipl, Garcia, Goldberg, Grayson, Guerreiro-Cacais, Guiducci, Gupta, Hattar, Heimbach, Helms, Henry, Heymann, Hickman, Holden, Huang, Kahlenberg, Kallenberg, Kaplan, Katayama, Kelkka, Kessenbrock, Kim, Kishida, Knight, Knight, Knight, Kovacs, Kuhl, Lamagna, Lande, Li, Lin, Lindwall, Liu, Lood, Maalouf, Maicas, Mancardi, Marciano, Marrakchi, Martinon, Mayadas, McColl, McGonagle, McGonagle, Merrill, Metzler, Metzler, Miller, Milora, Mocsai, Mocsai, Moline-Velazquez, Nemeth, Nesterovitch, O'Shea, Odobasic, Odobasic, Okumura, Ooi, Oswald, Palanichamy, Palmen, Patel, Pfister, Pieterse, Pietronigro, Pietrosimone, Rodrigues-Sousa, Rohrbach, Rumble, Ryckman, Sadik, Samavedam, Sangaletti, Scapini, Scapini, Schauer, Schmidt, Schon, Schon, Schreiber, Schreiber, Schreiber, Shao, Smith, Smith, So, Spengler, Steiger, Steinbach, Sumida, Summers, Tamás Németh, Terkeltaub, Tortola, Ueyama, van der Fits, Vandal, Volmering, Wallace, Walter, Willis, Wipke, Wise, Xiao, Yu, Zehntner, Zenaro, Zhang, Zhang   +151 more
core   +2 more sources

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Profiling Protein Citrullination in Extracellular Vesicles by Single‐Molecule Detection Using Direct Stochastic Optical Reconstruction Microscopy

Journal of Biophotonics, EarlyView.
This study identifies post‐translationally citrullinated/deiminated protein cargoes co‐localised to EV subtypes, using super resolution microscopy and dSTORM imaging. The findings expand current understanding of post‐translational modifications in EV‐mediated cellular communication.
Sarah R. Needham, Benjamin M. Davis, Pinar Uysal‐Onganer, Daniel J. Rolfe, Mariya Hristova, Igor Kraev, Jameel M. Inal, Sigrun Lange   +7 more
wiley   +1 more source

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease [PDF]

, 2017
BACKGROUND: Neutrophil extracellular traps (NETs) have been observed in the airway in COPD, but their clinical and pathophysiological implications have not been defined.OBJECTIVE: To determine if NETs are associated with disease severity in COPD, and how
Agusti, Alison J. Dicker, Andrew J. Cassidy, Bafadhel, Branzk, Brinkmann, Calverley, Caporaso, Caudrillier, Celli, Christopher J. Fong, Colin N.A. Palmer, Dickson, Donnelly, Dworski, Eleanor G. Pumphrey, Elizabeth Furrie, Farnworth, Flynn, Gill Brady, Gisli G. Einarsson, Grabcanovic-Musija, Gray, Greenwood, Guillermo Suarez-Cuartin, Haslett, Hoenderdos, J. Stuart Elborn, James D. Chalmers, Jiang, Juneau, Kessenbrock, Khandpur, Knight, Lange, Leidy, Lozano, Megan L. Crichton, Menegazzi, Metzler, Morris, Obermayer, Oriol Sibila, Papayannopoulos, Pascoe, Pavord, Pedersen, Richens, Sara E. Marshall, Savill, Sayah, Short, Speizer, Stuart Schembri, Vestbo, Wasyla Ibrahim, Willemse, Yipp, Zabieglo   +58 more
core   +2 more sources

Transcriptional firing helps to drive NETosis

Scientific Reports, 2017
AbstractNeutrophils are short-lived innate immune cells. These cells respond quickly to stimuli, and die within minutes to hours; the relevance of DNA transcription in dying neutrophils remains an enigma for several decades. Here we show that the transcriptional activity reflects the degree of DNA decondensation occurring in both NADPH oxidase 2 (Nox ...
Meraj A. Khan, Nades Palaniyar
openaire   +2 more sources