Network Pharmacology in Traditional Chinese Medicine [PDF]
Evidence-Based Complementary and Alternative Medicine, 2014 Network pharmacology is becoming a cutting-edge research field in current drug discovery and drug development thanks to rapid progress in systems biology, network biology, and chemical biology. By integrating reductionist and systems approaches as well as computational and experimental methods, network pharmacology has great potential to act as the ...
Li, Shao +4 more
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An efficient weighted network centrality approach for exploring mechanisms of action of the Ruellia herbal formula for treating rheumatoid arthritis [PDF]
Applied Network Science, 2023 Aim This study outlines an efficient weighted network centrality measure approach and its application in network pharmacology for exploring mechanisms of action of the Ruellia prostrata (RP) and Ruellia bignoniiflora (RB) herbal formula for treating ...
Peter Juma Ochieng +3 more
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Network pharmacology for mechanistically redefined comorbidities [PDF]
, 2020 Diabetes, hypertension and stroke are common comorbidities and the leading causes of death. Current therapies are symptom-oriented and are imprecise. One main reason for this is that these complex diseases are defined by a symptom in an organ and not by a molecular mechanism. Network medicine, however, shows that within the diseasome these comorbidites
Elbatrik, Mahmoud (Hassan Mahmoud)
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Network Pharmacology and Traditional Chinese Medicine [PDF]
, 2012 Traditional Chinese medicine (TCM), an age-old healthcare system derived from China, is a mainstream medicine in China and is also popular in many other parts of the world [1-3]. Due to historic reasons, the scientific base of TCM awaits consolidation but emerging evidence has be‐ gun to illustrate TCM as an area of important medical rediscoveries. For
Xu, Qihe, Fan, Qu, Olavi, Pelkonen
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Computational Molecular Networks and Network Pharmacology [PDF]
BioMed Research International, 2017 Kang Ning +4 more
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Identification of Potential COVID-19 Targets and Pathways Derivate from Various Phenolic Compounds from Chives (Allium schoenoprasum) by Using Network Pharmacology Approach [PDF]
, 2022 With the uncertainty of COVID-19 disease around the world, the discovery and development of novel treatments for COVID-19 becoming an emerging trend. Network pharmacology has been used for determining the potential targets from several diseases.
Buana, Bayu Cakra, Iksen
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Quantitative Systems Pharmacology and Biased Agonism at Opioid Receptors: A Potential Avenue for Improved Analgesics [PDF]
, 2022 Chronic pain is debilitating and represents a significant burden in terms of personal and socio-economic costs. Although opioid analgesics are widely used in chronic pain treatment, many patients report inadequate pain relief or relevant adverse effects,
Baiula M. +3 more
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Network analyses in systems pharmacology [PDF]
Bioinformatics, 2009 Abstract Systems pharmacology is an emerging area of pharmacology which utilizes network analysis of drug action as one of its approaches. By considering drug actions and side effects in the context of the regulatory networks within which the drug targets and disease gene products function, network analysis promises to greatly increase ...
Seth I. Berger, Ravi Iyengar
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Development of novel herbal compound formulations targeting neuroinflammation : network pharmacology, molecular docking, and experimental verification [PDF]
, 2023 Neuroinfammation plays an important role in the onset and progression of neurodegenerative diseases. Te multicomponent and multitarget approach may provide a practical strategy to address the complex pathological mechanisms of neuroinfammation. Tis study
Chang, Dennis Hsu-Tung (R7407) +2 more
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Network‐based Approaches in Pharmacology [PDF]
Molecular Informatics, 2017 AbstractIn drug discovery, network‐based approaches are expected to spotlight our understanding of drug action across multiple layers of information. On one hand, network pharmacology considers the drug response in the context of a cellular or phenotypic network.
Pierre Ducrot +3 more
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