Results 11 to 20 of about 334,131 (356)
Tinnitus: Network pathophysiology-network pharmacology [PDF]
Frontiers in Systems Neuroscience, 2012 Tinnitus, the phantom perception of sound, is a prevalent disorder. One in 10 adults has clinically significant subjective tinnitus, and for 1 in 100, tinnitus severely affects their quality of life. Despite the significant unmet clinical need for a safe
Ana Belen eElgoyhen +3 more
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Network pharmacology of JAK inhibitors [PDF]
Proceedings of the National Academy of Sciences, 2016 SignificanceJAK kinase inhibitors (JAKis) have advanced options for treatment of autoimmune diseases. Because JAKs are signaling hubs for several cytokine receptors, JAKis’ overall impact on the immune system and how they actually improve diseases like rheumatoid arthritis remain poorly understood.
Christophe Benoist +10 more
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Network analyses in systems pharmacology [PDF]
Bioinformatics, 2009 Abstract Systems pharmacology is an emerging area of pharmacology which utilizes network analysis of drug action as one of its approaches. By considering drug actions and side effects in the context of the regulatory networks within which the drug targets and disease gene products function, network analysis promises to greatly increase ...
Seth I. Berger, Ravi Iyengar
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Network‐based Approaches in Pharmacology [PDF]
Molecular Informatics, 2017 AbstractIn drug discovery, network‐based approaches are expected to spotlight our understanding of drug action across multiple layers of information. On one hand, network pharmacology considers the drug response in the context of a cellular or phenotypic network.
Pierre Ducrot +3 more
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SmartGraph: A Network Pharmacology Investigation Platform [PDF]
Journal of Cheminformatics, 2019 AbstractMotivationDrug discovery investigations need to incorporate network pharmacology concepts while navigating the complex landscape of drug-target and target-target interactions. This task requires solutions that integrate high-quality biomedical data, combined with analytic and predictive workflows as well as efficient visualization.
Gergely Zahoránszky-Kőhalmi +3 more
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Network Pharmacology in Traditional Chinese Medicine [PDF]
Evidence-Based Complementary and Alternative Medicine, 2014 Network pharmacology is becoming a cutting-edge research field in current drug discovery and drug development thanks to rapid progress in systems biology, network biology, and chemical biology. By integrating reductionist and systems approaches as well as computational and experimental methods, network pharmacology has great potential to act as the ...
Li, Shao +4 more
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Frontiers in Endocrinology, 2023 Objective(-)-Epigallocatechin-3-gallate (EGCG) has preventive effects on obesity-related precocious puberty, but its underlying mechanism remains unclear.
Qiuyun Gu +8 more
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Network Pharmacology and Pharmacological Mechanism of CV-3 in Atrial Fibrillation
Evidence-Based Complementary and Alternative Medicine, 2022 The high fatality and disability rate of atrial fibrillation (AF) strongly promote the development of pathogenesis and treatment of AF that is of great value. The present research attempted to clarify potential mechanisms of Mujiangzi oil (CV-3) in treating AF by constructing an AF cardiomyocytes model and using a network pharmacology approach.
Zundong Wang +5 more
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Systematically Deciphering the Pharmacological Mechanism of Fructus Aurantii via Network Pharmacology [PDF]
Evidence-Based Complementary and Alternative Medicine, 2021 Fructus Aurantii (FA) is a traditional herbal medicine that has been widely used for thousands of years in China and possesses a variety of pharmacological effects. However, the active ingredients in FA and the potential mechanisms of its therapeutic effects have not been fully explored.
Qionglong Jin +5 more
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Chinese Medicine, 2021 Background Compound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the digestive system. However, the underlying mechanism of CKI in pancreatic cancer (PC) treatment has not been
Chao Wu +15 more
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