Results 11 to 20 of about 337,823 (305)

SmartGraph: A Network Pharmacology Investigation Platform [PDF]

Journal of Cheminformatics, 2019
AbstractMotivationDrug discovery investigations need to incorporate network pharmacology concepts while navigating the complex landscape of drug-target and target-target interactions. This task requires solutions that integrate high-quality biomedical data, combined with analytic and predictive workflows as well as efficient visualization.
Zahoránszky-Kőhalmi, Gergely, Sheils, Timothy, Oprea, Tudor I.   +2 more
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Network pharmacology: curing causal mechanisms instead of treating symptoms [PDF]

Trends in Pharmacological Sciences, 2022
Para enfermedades complejas, la mayoría de los medicamentos son altamente ineficaces y la tasa de éxito del descubrimiento de fármacos está en constante declive. Si bien la baja calidad, los problemas de reproducibilidad y la irrelevancia traslacional de la mayoría de las investigaciones básicas y preclínicas han contribuido a esto, la actual ...
Cristian Nogales, Zeinab M. Mamdouh, Markus List, Christina Kiel, Ana I. Casas, Harald Schmidt   +5 more
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Network pharmacology of JAK inhibitors [PDF]

Proceedings of the National Academy of Sciences, 2016
SignificanceJAK kinase inhibitors (JAKis) have advanced options for treatment of autoimmune diseases. Because JAKs are signaling hubs for several cytokine receptors, JAKis’ overall impact on the immune system and how they actually improve diseases like rheumatoid arthritis remain poorly understood.
Devapregasan, Moodley, Hideyuki, Yoshida, Sara, Mostafavi, Natasha, Asinovski, Adriana, Ortiz-Lopez, Peter, Symanowicz, Jean-Baptiste, Telliez, Martin, Hegen, James D, Clark, Diane, Mathis, Christophe, Benoist   +10 more
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Systematically Deciphering the Pharmacological Mechanism of Fructus Aurantii via Network Pharmacology [PDF]

Evidence-Based Complementary and Alternative Medicine, 2021
Fructus Aurantii (FA) is a traditional herbal medicine that has been widely used for thousands of years in China and possesses a variety of pharmacological effects. However, the active ingredients in FA and the potential mechanisms of its therapeutic effects have not been fully explored.
Qionglong Jin, Jie Lu, Renhui Gao, Jiaying Xu, Xiaoyan Pan, Lichang Wang   +5 more
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Huoxue Qingre decoction used for treatment of coronary heart disease network analysis and metabolomic evaluation

Frontiers in Pharmacology, 2022
Objective: Network pharmacology provides new methods and references for the research of traditional Chinese medicine, but some problems remain, such as single evaluation components and index methods, imperfect relevant databases, unscientific prediction ...
Yu-Qing Tan, Min Jin, Xuan-Hui He, Heng-Wen Chen   +3 more
doaj   +1 more source

Network analyses in systems pharmacology [PDF]

Bioinformatics, 2009
Abstract Systems pharmacology is an emerging area of pharmacology which utilizes network analysis of drug action as one of its approaches. By considering drug actions and side effects in the context of the regulatory networks within which the drug targets and disease gene products function, network analysis promises to greatly increase ...
Seth I, Berger, Ravi, Iyengar
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A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation

Chinese Medicine, 2021
Background Compound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the digestive system. However, the underlying mechanism of CKI in pancreatic cancer (PC) treatment has not been
Chao Wu, Zhi-Hong Huang, Zi-Qi Meng, Xiao-Tian Fan, Shan Lu, Ying-Ying Tan, Lei-Ming You, Jia-Qi Huang, Antony Stalin, Pei-Zhi Ye, Zhi-Shan Wu, Jing-Yuan Zhang, Xin-Kui Liu, Wei Zhou, Xiao-Meng Zhang, Jia-Rui Wu   +15 more
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The therapeutic role and potential mechanism of EGCG in obesity-related precocious puberty as determined by integrated metabolomics and network pharmacology

Frontiers in Endocrinology, 2023
Objective(-)-Epigallocatechin-3-gallate (EGCG) has preventive effects on obesity-related precocious puberty, but its underlying mechanism remains unclear.
Qiuyun Gu, Lina Xia, Qiuju Du, Ying Shao, Jieyi He, Peiying Wu, Lingwei Liang, Xiuhua Shen, Xiuhua Shen   +8 more
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Network‐based Approaches in Pharmacology [PDF]

Molecular Informatics, 2017
AbstractIn drug discovery, network‐based approaches are expected to spotlight our understanding of drug action across multiple layers of information. On one hand, network pharmacology considers the drug response in the context of a cellular or phenotypic network.
Baptiste, Boezio, Karine, Audouze, Pierre, Ducrot, Olivier, Taboureau   +3 more
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Integrated Network Pharmacology and Metabonomics to Reveal the Myocardial Protection Effect of Huang-Lian-Jie-Du-Tang on Myocardial Ischemia

Frontiers in Pharmacology, 2021
Myocardial ischemia (MI) is one of the most common cardiovascular diseases with high incidence and mortality. Huang-Lian-Jie-Du-Tang (HLJDT) is a classic traditional Chinese prescription to clear “heat” and “poison”.
Li Li, Weixing Dai, Wenting Li, Yumao Zhang, Yanqin Wu, Chenfeng Guan, Anye Zhang, Hui Huang, Yuzhen Li   +8 more
doaj   +1 more source