Results 11 to 20 of about 7,014,814 (396)
Tinnitus: Network pathophysiology-network pharmacology [PDF]
Frontiers in Systems Neuroscience, 2012 Tinnitus, the phantom perception of sound, is a prevalent disorder. One in 10 adults has clinically significant subjective tinnitus, and for 1 in 100, tinnitus severely affects their quality of life. Despite the significant unmet clinical need for a safe
Ana Belen eElgoyhen +3 more
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Briefings in Bioinformatics, 2023 Network pharmacology (NP) provides a new methodological perspective for understanding traditional medicine from a holistic perspective, giving rise to frontiers such as traditional Chinese medicine network pharmacology (TCM-NP).
Peng Zhang +6 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2023 Objective: Curcumin is a plant polyphenol extracted from the Chinese herb turmeric. It was found that curcumin has good anti-cancer properties in a variety of cancers, but the exact mechanism is not clear.
Qingmin He +7 more
semanticscholar +1 more source
Shipin gongye ke-ji, 2022 Objective: Network pharmacology was used to predict potential compounds, targets and pathways of action in hawthorn leaves for the treatment of hyperlipidaemia, and the network pharmacology predictions were validated in conjunction with target enzyme and
Xuegui LIU +6 more
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Journal of Cellular and Molecular Medicine, 2023 Fenugreek is an ancient herb that has been used for centuries to treat diabetes. However, how the fenugreek‐derived chemical compounds work in treating diabetes remains unclarified.
Wenfeng Luo +10 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Overview: The treatment of chronic renal failure (CRF) with traditional Chinese medicine has attracted much attention, but its mechanism is not clear. Network pharmacology is an effective strategy for exploring the interaction mechanisms between Chinese ...
Hongyu Luo +11 more
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Network pharmacology of JAK inhibitors [PDF]
Proceedings of the National Academy of Sciences, 2016 SignificanceJAK kinase inhibitors (JAKis) have advanced options for treatment of autoimmune diseases. Because JAKs are signaling hubs for several cytokine receptors, JAKis’ overall impact on the immune system and how they actually improve diseases like rheumatoid arthritis remain poorly understood.
Christophe Benoist +10 more
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Network analyses in systems pharmacology [PDF]
Bioinformatics, 2009 Abstract Systems pharmacology is an emerging area of pharmacology which utilizes network analysis of drug action as one of its approaches. By considering drug actions and side effects in the context of the regulatory networks within which the drug targets and disease gene products function, network analysis promises to greatly increase ...
Seth I. Berger, Ravi Iyengar
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Network‐based Approaches in Pharmacology [PDF]
Molecular Informatics, 2017 AbstractIn drug discovery, network‐based approaches are expected to spotlight our understanding of drug action across multiple layers of information. On one hand, network pharmacology considers the drug response in the context of a cellular or phenotypic network.
Pierre Ducrot +3 more
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SmartGraph: A Network Pharmacology Investigation Platform [PDF]
Journal of Cheminformatics, 2019 AbstractMotivationDrug discovery investigations need to incorporate network pharmacology concepts while navigating the complex landscape of drug-target and target-target interactions. This task requires solutions that integrate high-quality biomedical data, combined with analytic and predictive workflows as well as efficient visualization.
Gergely Zahoránszky-Kőhalmi +3 more
openaire +6 more sources