Results 21 to 30 of about 628,285 (376)

Huoxue Qingre decoction used for treatment of coronary heart disease network analysis and metabolomic evaluation

Frontiers in Pharmacology, 2022
Objective: Network pharmacology provides new methods and references for the research of traditional Chinese medicine, but some problems remain, such as single evaluation components and index methods, imperfect relevant databases, unscientific prediction ...
Yu-Qing Tan, Min Jin, Xuan-Hui He, Heng-Wen Chen   +3 more
doaj   +1 more source

SmartGraph: A Network Pharmacology Investigation Platform [PDF]

Journal of Cheminformatics, 2019
AbstractMotivationDrug discovery investigations need to incorporate network pharmacology concepts while navigating the complex landscape of drug-target and target-target interactions. This task requires solutions that integrate high-quality biomedical data, combined with analytic and predictive workflows as well as efficient visualization.
Gergely Zahoránszky-Kőhalmi, Gergely Zahoránszky-Kőhalmi, Timothy Sheils, Tudor I. Oprea   +3 more
openaire   +6 more sources

Elucidation of the mechanism of action of the anticholecystitis effect of the Tibetan medicine “Dida” using network pharmacology [PDF]

, 2020
Purpose: To study the mechanism involved in the anti-cholecystitis effect the Tibetan medicine “Dida”, using network pharmacology-integrated molecular docking simulationsMethods: In this investigation, the bioactive compounds of Dida were collected ...
Fan, Fang-Fang, Li, Xuan-Hao, Liu, Chuan, Tu, Ya, Wang, Wen-Xiang, Zhang, Yi   +5 more
core   +2 more sources

Network Pharmacology and Pharmacological Mechanism of CV-3 in Atrial Fibrillation

Evidence-Based Complementary and Alternative Medicine, 2022
The high fatality and disability rate of atrial fibrillation (AF) strongly promote the development of pathogenesis and treatment of AF that is of great value. The present research attempted to clarify potential mechanisms of Mujiangzi oil (CV-3) in treating AF by constructing an AF cardiomyocytes model and using a network pharmacology approach.
Zundong Wang, Zhen Zeng, Yongsheng Hu, Hengcan Sun, Ying Tang, Weiqin Liu   +5 more
openaire   +2 more sources

Systematically Deciphering the Pharmacological Mechanism of Fructus Aurantii via Network Pharmacology [PDF]

Evidence-Based Complementary and Alternative Medicine, 2021
Fructus Aurantii (FA) is a traditional herbal medicine that has been widely used for thousands of years in China and possesses a variety of pharmacological effects. However, the active ingredients in FA and the potential mechanisms of its therapeutic effects have not been fully explored.
Qionglong Jin, Jie Lu, Renhui Gao, Jiaying Xu, Xiaoyan Pan, Lichang Wang   +5 more
openaire   +3 more sources

Elucidation of the mechanisms underlying the anticholecystitis effect of the Tibetan medicine “Dida” using Network pharmacology [PDF]

, 2020
Purpose: To study the mechanism involved in the anti-cholecystitis effect the Tibetan medicine “Dida”, using network pharmacology-integrated molecular docking simulationsMethods: In this investigation, the bioactive compounds of Dida were collected ...
Fan, Fang-Fang, Li, Xuan-Hao, Liu, Chuan, Tu, Ya, Wang, Wen-Xiang, Zhang, Yi   +5 more
core   +2 more sources

A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation

Chinese Medicine, 2021
Background Compound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the digestive system. However, the underlying mechanism of CKI in pancreatic cancer (PC) treatment has not been
Chao Wu, Zhi-Hong Huang, Zi-Qi Meng, Xiao-Tian Fan, Shan Lu, Ying-Ying Tan, Lei-Ming You, Jia-Qi Huang, Antony Stalin, Pei-Zhi Ye, Zhi-Shan Wu, Jing-Yuan Zhang, Xin-Kui Liu, Wei Zhou, Xiao-Meng Zhang, Jia-Rui Wu   +15 more
doaj   +1 more source

The therapeutic role and potential mechanism of EGCG in obesity-related precocious puberty as determined by integrated metabolomics and network pharmacology

Frontiers in Endocrinology, 2023
Objective(-)-Epigallocatechin-3-gallate (EGCG) has preventive effects on obesity-related precocious puberty, but its underlying mechanism remains unclear.
Qiuyun Gu, Lina Xia, Qiuju Du, Ying Shao, Jieyi He, Peiying Wu, Lingwei Liang, Xiuhua Shen, Xiuhua Shen   +8 more
doaj   +1 more source

Comparative studies of the anti-thrombotic effects of saffron and HongHua based on network pharmacology [PDF]

, 2020
Purpose: To investigate the comparative anti-thrombotic effects of saffron and Honghua, and also to explore possible mechanisms in thrombosis based on network pharmacology.
Chen, Shuting, Hu, Yingjie, Jiang, Jinyan, Jiang, Shanshan, Jiang, Yu, Li, Qiaoqiao, Lin, Susu, liu, Ling, Tong, Yingpeng, Wang, Ping   +9 more
core   +2 more sources

Application of network pharmacology in the study of the mechanism of action of traditional chinese medicine in the treatment of COVID-19

Frontiers in Pharmacology, 2022
Network pharmacology was rapidly developed based on multidisciplinary holistic analysis of biological systems, which has become a popular tool in traditional Chinese medicine (TCM) research in recent years.
Shihao Zheng, Tianyu Xue, Bin Wang, Haolin Guo, Qiquan Liu, Qiquan Liu   +5 more
doaj   +1 more source