Results 21 to 30 of about 7,014,814 (396)

Network Pharmacology in Traditional Chinese Medicine [PDF]

Evidence-Based Complementary and Alternative Medicine, 2014
Network pharmacology is becoming a cutting-edge research field in current drug discovery and drug development thanks to rapid progress in systems biology, network biology, and chemical biology. By integrating reductionist and systems approaches as well as computational and experimental methods, network pharmacology has great potential to act as the ...
Li, Shao, Fan, Tai-Ping, Jia, Wei, Lu, Aiping, Zhang, Weidong   +4 more
openaire   +4 more sources

Is there a potential of misuse for venlafaxine and bupropion? [PDF]

, 2018
© 2018 Schifano and Chiappini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the ...
Anderson, Augustin, Baker, Baribeau, Bolden-Watson, Campagne, Carvalho, Chiappini, Chiappini, Chouinard, Cosci, Cutler, Deluca, Evans, Fava, Fava, Fountain, Francesconi, Groot, Harvey, Harvey, Hill, Hilliard, Holland, Hopper, Hu, Kantor, Kelly, Khurshid, Kim, Koga, Kotzalidis, Langguth, Lewin, Llorca, Maj, McCormick, Muth, Nelson, Orsolini, Parker, Phillips, Quaglio, Redrobe, Reeves, Renoir, Rettew, Rudolph, Sabljić, Schifano, Schifano, Shang, Shenouda, Sir, Stahl, Stahl, Stahl, Stall, Stassinos, Taylor, Vento, Weikop, Welsh, Wilson, Yoon   +64 more
core   +12 more sources

Huoxue Qingre decoction used for treatment of coronary heart disease network analysis and metabolomic evaluation

Frontiers in Pharmacology, 2022
Objective: Network pharmacology provides new methods and references for the research of traditional Chinese medicine, but some problems remain, such as single evaluation components and index methods, imperfect relevant databases, unscientific prediction ...
Yu-Qing Tan, Min Jin, Xuan-Hui He, Heng-Wen Chen   +3 more
doaj   +1 more source

Network Pharmacology and Pharmacological Mechanism of CV-3 in Atrial Fibrillation

Evidence-Based Complementary and Alternative Medicine, 2022
The high fatality and disability rate of atrial fibrillation (AF) strongly promote the development of pathogenesis and treatment of AF that is of great value. The present research attempted to clarify potential mechanisms of Mujiangzi oil (CV-3) in treating AF by constructing an AF cardiomyocytes model and using a network pharmacology approach.
Zundong Wang, Zhen Zeng, Yongsheng Hu, Hengcan Sun, Ying Tang, Weiqin Liu   +5 more
openaire   +2 more sources

Systematically Deciphering the Pharmacological Mechanism of Fructus Aurantii via Network Pharmacology [PDF]

Evidence-Based Complementary and Alternative Medicine, 2021
Fructus Aurantii (FA) is a traditional herbal medicine that has been widely used for thousands of years in China and possesses a variety of pharmacological effects. However, the active ingredients in FA and the potential mechanisms of its therapeutic effects have not been fully explored.
Qionglong Jin, Jie Lu, Renhui Gao, Jiaying Xu, Xiaoyan Pan, Lichang Wang   +5 more
openaire   +3 more sources

A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation

Chinese Medicine, 2021
Background Compound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the digestive system. However, the underlying mechanism of CKI in pancreatic cancer (PC) treatment has not been
Chao Wu, Zhi-Hong Huang, Zi-Qi Meng, Xiao-Tian Fan, Shan Lu, Ying-Ying Tan, Lei-Ming You, Jia-Qi Huang, Antony Stalin, Pei-Zhi Ye, Zhi-Shan Wu, Jing-Yuan Zhang, Xin-Kui Liu, Wei Zhou, Xiao-Meng Zhang, Jia-Rui Wu   +15 more
doaj   +1 more source

The therapeutic role and potential mechanism of EGCG in obesity-related precocious puberty as determined by integrated metabolomics and network pharmacology

Frontiers in Endocrinology, 2023
Objective(-)-Epigallocatechin-3-gallate (EGCG) has preventive effects on obesity-related precocious puberty, but its underlying mechanism remains unclear.
Qiuyun Gu, Lina Xia, Qiuju Du, Ying Shao, Jieyi He, Peiying Wu, Lingwei Liang, Xiuhua Shen, Xiuhua Shen   +8 more
doaj   +1 more source

Integrated Network Pharmacology and Metabonomics to Reveal the Myocardial Protection Effect of Huang-Lian-Jie-Du-Tang on Myocardial Ischemia

Frontiers in Pharmacology, 2021
Myocardial ischemia (MI) is one of the most common cardiovascular diseases with high incidence and mortality. Huang-Lian-Jie-Du-Tang (HLJDT) is a classic traditional Chinese prescription to clear “heat” and “poison”.
Li Li, Weixing Dai, Wenting Li, Yumao Zhang, Yanqin Wu, Chenfeng Guan, Anye Zhang, Hui Huang, Yuzhen Li   +8 more
doaj   +1 more source

Personalized medicine : the impact on chemistry [PDF]

, 2010
An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew, Singer, Donald R. J., Taylor, Paul C., Watkins, John   +3 more
core   +1 more source

Best practices to maximize the use and reuse of quantitative and systems pharmacology models: recommendations from the United Kingdom quantitative and systems pharmacology network [PDF]

, 2018
The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts.
Amy Cheung, S. Y., Chappell, Michael J., Chelliah, Vijayalakshmi, Cucurull-Sanchez, Lourdes, Derks, Gianne, Malik-Sheriff, Rahuman S., Penney, Mark, Phipps, Alex, Timmis, Jon, Tindall, Marcus J., van der Graaf, Piet H., Vicini, Paolo, Yates, James W. T.   +12 more
core   +3 more sources