Results 231 to 240 of about 4,546,897 (298)

Air pollution and hepatocellular carcinoma: Integrated network toxicology, machine learning, molecular docking and multiomics analysis. [PDF]

Oncol Lett
Wang X, Qin H, Jing J, Liu Y, Guo L, Liu H, Zhang W.   +6 more
europepmc   +1 more source

Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science

Clinical Pharmacology &Therapeutics, EarlyView.
New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS).
Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi, Jahan Cooper, Tromondae K. Feaster, Paula L. Hyland, Lidiya Stavitskaya, Wendy W. Wu, Jeffry Florian, Rodney Rouse   +9 more
wiley   +1 more source

Integrated network toxicology, bioinformatics, and molecular docking reveal the potential molecular mechanisms linking bisphenol A to glioma progression. [PDF]

Front Bioinform
Miao L, Hou F.
europepmc   +1 more source

Monitoring Injected Drug Use in Greece Through Syringe Residue Analysis: A Multicity Study Within the ESCAPE Network

Drug Testing and Analysis, EarlyView.
A total of 2121 used syringes were analyzed in Athens, Thessaloniki, and Patras between 2022 and 2024. Distinct drug‐use patterns were observed across the three cities. Benzodiazepines, pregabalin, methadone, and fentanyl were increasingly detected in 2024.
Christina Matiaki, Anastasios Trakakis, Athanasios Theocharis, Chara Parpala, Chara Kotsailidou, Alexandros Psarianos, Emmanouil Chatzichristofis, Eleni Zagelidu, Panagiota Roussou, Nikolaos Raikos, Orthodoxia Mastrogianni   +10 more
wiley   +1 more source

Integration of multi-omics and network toxicology reveals TLR4-mediated nephrotoxicity induced by arecoline. [PDF]

BMC Pharmacol Toxicol
Yuan J, Chen L, Wang X, Jiang Z, Jin D, Bai Y, Pan X, Li Y, Lin F, Cai Y.   +9 more
europepmc   +1 more source

An Investigation Into the Yields of 3,4‐Methylenedioxyphenyl‐2‐propanone (MDP2P) From Glycidate Pre‐Precursors

Drug Testing and Analysis, EarlyView.
Hydrolysis of the glycidate pre‐precursors MMDMG and EMDMG was evaluated for MDP2P production. Acid hydrolysis of MMDMG (HCl, 100°C, 18 h) yielded the highest MDP2P recovery (79%), whereas base hydrolysis produced only slightly lower yields (73%), demonstrating both pathways are effective routes to this key MDMA precursor.
Alexandra L. Mercieca, Ella S. Schuett, Andrew M. McDonagh, Shanlin Fu, Morgan Alonzo   +4 more
wiley   +1 more source

A report on the mechanisms of sweeteners in four musculoskeletal disorders: Insights from network toxicology, molecular docking, and molecular dynamics simulations. [PDF]

PLoS One
Niu T, Zhang X, Jia Y, Liu Z, Cao D, Tian Y, Yuan H.   +6 more
europepmc   +1 more source

Unveiling the Molecular Mechanism of 6PPD and 6PPD-Q in Lipid-Metabolism-Related Diseases Through Network Toxicology and Experimental Validation. [PDF]

Int J Mol Sci
Li Z, Luo Y, Zhao J, Wang S, Zhang Y.
europepmc   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Network Toxicology and Molecular Docking Analysis of Targets and Potential Mechanisms of PEEK-Induced Bone Resorption. [PDF]

Int J Mol Sci
Hu Y, Zhang L, Liu Z, Lu C, Li H, Yu Q, Lü S, Liu L, Liu J.   +8 more
europepmc   +1 more source