Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter [PDF]
eLifeN -Acetylneuraminic acid (Neu5Ac) is a negatively charged nine-carbon amino sugar that is often the peripheral sugar in human cell-surface glycoconjugates.
Parveen Goyal +7 more
doaj +4 more sources
Development of mumps virus-specific sialidase imaging probes through chemical modifications of sialic acid [PDF]
Scientific ReportsSome viruses, such as mumps virus (MuV), possess sialidases that cleave terminal sialic acids, primarily N-acetylneuraminic acid (Neu5Ac), from glycans.
Yutaka Narimichi +7 more
doaj +2 more sources
Microbial Production of N-Acetylneuraminic Acid Using Metabolically Engineered Escherichia coli and Bacillus subtilis: Advances and Perspectives [PDF]
FoodsN-Acetylneuraminic acid (Neu5Ac), the predominant form of sialic acids (Sias), is extensively utilized in the food, pharmaceutical, and cosmetic industries.
Jingru Dang +4 more
doaj +2 more sources
Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism. [PDF]
Adv Sci (Weinh)Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Joyce K +8 more
europepmc +2 more sources
Maternal Neu5Ac Supplementation During Pregnancy Improves Offspring Learning and Memory Ability in Rats [PDF]
Frontiers in Nutrition, 2021 Sialic acids are postulated to improve cognitive abilities. This study aimed to evaluate the effects of sialic acid on behavior when administered in a free form as N-acetylneuraminic acid (Neu5Ac) to pregnant mothers or rat pups.
DongSheng Bian +5 more
doaj +3 more sources
Dysbiosis-associated gut bacterium Ruminococcus gnavus varies at the strain level in its ability to utilize key mucin component sialic acid [PDF]
Microbiology SpectrumRuminococcus gnavus is a prevalent human gut commensal bacterium with known roles in intestinal mucus degradation, including by catabolism of the terminal mucin sugar sialic acid. While R.
Olga M. Sokolovskaya +8 more
doaj +2 more sources
Investigating the Utility of Leukocyte Sialic Acid Measurements in Lysosomal Free Sialic Acid Storage Disorder [PDF]
JIMD ReportsLysosomal free sialic acid storage disorder (FSASD) is a rare, multisystem neurodegenerative disease caused by biallelic pathogenic variants in SLC17A5, encoding sialin.
Marya S. Sabir +9 more
doaj +2 more sources
Variability of Sialic Acids in Beef Breeds and Nutritional Implications in Red Meat [PDF]
MoleculesThis study examines the variability of sialic acids, specifically N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), in beef from seven cattle breeds (Holstein Friesian, Red Pied, Maremmana, Chianina, Charolais, Limousin, and ...
Michela Contò +3 more
doaj +2 more sources
Correlation of Serum N-Acetylneuraminic Acid with the Risk of Moyamoya Disease
Brain Sciences, 2023 N-acetylneuraminic acid (Neu5Ac) is a functional metabolite and has been demonstrated to be a risk factor for cardiovascular diseases. It is not clear whether Neu5Ac is associated with a higher risk of cerebrovascular disorders, especially moyamoya ...
Chenglong Liu +15 more
doaj +1 more source
Recent advances on N-acetylneuraminic acid: Physiological roles, applications, and biosynthesis
Synthetic and Systems Biotechnology, 2023 N-Acetylneuraminic acid (Neu5Ac), the most common type of Sia, generally acts as the terminal sugar in cell surface glycans, glycoconjugates, oligosaccharides, lipo-oligosaccharides, and polysaccharides, thus exerting numerous physiological functions ...
Mingli Zhao +4 more
doaj +1 more source