Results 11 to 20 of about 16,068 (197)
Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors [PDF]
Nature Communications, 2014 Mammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). Neu5Gc is synthesized from Neu5Ac by the enzyme
Böhm, Raphael +14 more
core +6 more sources
Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac [PDF]
Marine Drugs, 2003 : CMP-Neu5Ac is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates. In this paper, a large-scale production system of CMP-Neu5Ac by a single strain is reported. The co-expression of Neu5Ac aldolase (EC4.1.3.3) and CMP-Neu5Ac
Min Xiao +6 more
doaj +2 more sources
Metabolites, 2023 The healthy growth of infants during early life is associated with lifelong consequences. Breastfeeding has positive impacts on reducing obesity risk, which is likely due to the varied components of breast milk, such as N-acetylneuraminic acid (Neu5Ac ...
Runze Ouyang +14 more
doaj +1 more source
Biological functions of sialic acid as a component of bacterial endotoxin
Frontiers in Microbiology, 2022 Lipopolysaccharide (endotoxin, LPS) is an important Gram-negative bacteria antigen. LPS of some bacteria contains sialic acid (Neu5Ac) as a component of O-antigen (O-Ag), in this review we present an overview of bacteria in which the presence of Neu5Ac ...
Bartłomiej Dudek +6 more
doaj +1 more source
Synthesis of Neu5Ac-Gal-functionalized gold glyconanoparticles [PDF]
Carbohydrate Research, 2009 Neu5Ac-Gal-containing neoglycoside 1 was convergently synthesized through Cu(I)-catalyzed 1,3-dipolar cycloaddition of methyl (6-azidohexyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-O-alpha-d-glycero-d-galacto-2-nonulopyranosyl)uronate and 11-thioacetylundecyl 2,4,6-tri-O-benzoyl-3-O-propargyl-beta-d-galactopyranoside.
Lei, Zhang, Guohua, Wei, Yuguo, Du
openaire +2 more sources
Shift of the reaction equilibrium at high pressure in the continuous synthesis of neuraminic acid
Beilstein Journal of Organic Chemistry, 2022 The importance of a compound that helps fight against influenza is, in times of a pandemic, self-evident. In order to produce these compounds in vast quantities, many researchers consider continuous flow reactors in chemical industry as next stepping ...
Jannis A. Reich +5 more
doaj +1 more source
Comparison of sialic acid content in bovine and buffalo milk and meat
Revista Científica, 2023 Animal-origin food, such as meat and milk, are important sources of sialic acids (SIAs) with relevant implications for human health. Two significant SIAs in mammals are N-acetyl-neuraminic acid (Neu5Ac) and N- glycolylneuraminic acid (Neu-5Gc).
Michela Contò +2 more
doaj +1 more source
BMC Cardiovascular Disorders, 2020 Background N-acetylneuraminic acid (Neu5Ac) is a functional metabolite involved in coronary artery disease (CAD). We aimed to evaluate the relationship between serum Neu5Ac and the risk and prognosis of acute coronary syndrome (ACS) in a real-world ...
Miao-Nan Li +11 more
doaj +1 more source
Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs [PDF]
Scientific Reports, 2013 After the knock-out (KO) of α1,3 galactosyltransfease (Gal-T), the Hanganutziu-Deicher antigen became a major antigen of the "non-Gal antigen" that is implicated in subsequent xenograft rejection. For deletion of non-Gal antigen, we successfully produced zinc finger nuclease (ZFN)-mediated monoallelic/biallelic male and female CMP-N-acetylneuraminic ...
Kwon, Deug-Nam +13 more
openaire +2 more sources
Frontiers in Microbiology, 2023 N-acetylneuraminic acid (Neu5Ac) possesses the ability to promote mental health and enhance immunity and is widely used in both medicine and food fields as a supplement.
Quanzhen Liu +6 more
doaj +1 more source