Salmonella Degrades the Host Glycocalyx Leading to Altered Infection and Glycan Remodeling. [PDF]
, 2016 Complex glycans cover the gut epithelial surface to protect the cell from the environment. Invasive pathogens must breach the glycan layer before initiating infection.
Arabyan, Narine +11 more
core +1 more source
N-Acetylneuraminic acid attenuates hypercoagulation on high fat diet-induced hyperlipidemic rats
Food & Nutrition Research, 2015 Background and objective: N-Acetylneuraminic acid (Neu5Ac), a type of sialic acid, has close links with cholesterol metabolism and is often used as a biomarker in evaluating the risk of cardiovascular diseases.
Zhang Yida +6 more
doaj +1 more source
Mass Spectrometry in the Elucidation of the Glycoproteome of Bacterial Pathogens [PDF]
, 2010 Presently some three hundred post-translational modifications are known to occur in bacteria in vivo. Many of these modifications play critical roles in the regulation of proteins and control key biological processes.
Graham, Robert L. J., Hess, Sonja
core +1 more source
Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection. [PDF]
, 2019 Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis.
Barnard, Karen N +10 more
core +3 more sources
A Water Soluble Pd2L4 Cage for Selective Binding of Neu5Ac
Chemistry – A European Journal, 2021 AbstractThe sialic acid N‐acetylneuraminic acid (Neu5Ac) and its derivatives are involved in many biological processes including cell‐cell recognition and infection by influenza. Molecules that can recognize Neu5Ac might thus be exploited to intervene in or monitor such events.
Xander Schaapkens +4 more
openaire +4 more sources
Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking [PDF]
, 2009 We have previously reported that galectin-4, a tandem repeat-type galectin, regulates the raft-dependent delivery of glycoproteins to the apical brush border membrane of enterocyte-like HT-29 cells.
Altschuler Y. +8 more
core +3 more sources
Mechanistic study of CMP‐Neu5Ac hydrolysis by α2,3‐sialyltransferase from Pasteurella dagmatis [PDF]
FEBS Letters, 2014 Bacterial sialyltransferases of the glycosyltransferase family GT‐80 exhibit pronounced hydrolase activity toward CMP‐activated sialyl donor substrates. Using in situ proton NMR, we show that hydrolysis of CMP‐Neu5Ac by Pasteurella dagmatis α2,3‐sialyltransferase (PdST) occurs with axial‐to‐equatorial inversion of the configuration at the anomeric ...
Schmölzer, Katharina +6 more
openaire +2 more sources
mBio, 2019 Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative bacterial pathogen that is adapted exclusively to human hosts. NTHi utilizes sialic acid from the host as a carbon source and as a terminal sugar on the outer membrane glycolipid ...
Preston S. K. Ng +10 more
doaj +1 more source
E-Journal of Chemistry, 2007 A molecular imprinting technique was applied in this work to detect N-acetylneuraminic acid (Neu5Ac) and its analogue structure. Twomolecularly imprinted polymers (MIP) were prepared using Neu 5Ac as the template molecule, as well as methacrylic acid ...
Hsin-Hung Pan +3 more
doaj +1 more source
The Urinary Bladder is Rich in Glycosphingolipids Composed of Phytoceramides
Journal of Lipid Research, 2022 Glycosphingolipids (GSLs) are composed of a polar glycan chain and a hydrophobic tail known as ceramide. Together with variation in the glycan chain, ceramides exhibit tissue-specific structural variation in the long-chain base (LCB) and N-acyl chain ...
Takashi Watanabe +10 more
doaj +1 more source