Results 71 to 80 of about 16,068 (197)
Post-Glycosylation Modification of Sialic Acid and Its Role in Virus Pathogenesis
Vaccines, 2019 Sialic acids are a family of nine carbon keto-aldononulosonic acids presented at the terminal ends of glycans on cellular membranes. α-Linked sialoglycoconjugates often undergo post-glycosylation modifications, among which O-acetylation of N-acetyl ...
Simon S. Park
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Thoroughbred mare's milk exhibits a unique and diverse free oligosaccharide profile. [PDF]
, 2018 The Thoroughbred is among the most valuable horse breeds, and its husbandry is a major industry. Mare's milk plays a major role in the health of neonatal foals. Although the main components of mare's milk are broadly characterized, free oligosaccharides (
Barile, Daniela +3 more
core +3 more sources
Enhancing Lipidomics With High‐Resolution Ion Mobility‐Mass Spectrometry
PROTEOMICS, EarlyView.ABSTRACT Lipids, indispensable yet structurally intricate biomolecules, serve as critical regulators of cellular function and disease progression. Conventional lipidomics, constrained by limited resolution for isomeric and low‐abundance species, has been transformed by ion mobility‐mass spectrometry (IM‐MS).
Gaoyuan Lu +3 more
wiley +1 more source
Perinatal Gut Dysbiosis Reduces Milk Oligosaccharides via LPS‐Mediated Gut–Mammary Signaling in Mice
Food Frontiers, Volume 7, Issue 2, March 2026.Maternal gut dysbiosis elevates Gram‐negative bacterial lipopolysaccharide (LPS), which enters circulation and accumulates in mammary tissue. This compromises the blood–milk barrier and suppresses key enzymatic genes, ultimately reducing milk oligosaccharide synthesis and potentially affecting neonatal gut microbiota through breastfeeding.
Man‐Lin Zhou +9 more
wiley +1 more source
Chemistry of N-Acetylneuraminic Acid (Neu5Ac)
Trends in Glycoscience and Glycotechnology, 2004 シアル酸 (Neu5Ac, Neu5Gc, andKDN) は単糖の中で最も複雑な構造もつ化合物である。シアル酸は分子量320程度の小さな分子にもかかわらず多くの官能基から構成されている。またそれらの官能基が条件によって糖特有の平衡状態とる。このことがシアル酸の合成化学を始めるにあたり難くしている。シアル酸は種々の試薬に大変敏感に反応する性質を持っているので、目的化合物を合成するには経験的な反応条件が必要となる。ここでは、既に報告されている沢山の論文の中からシアル酸の中で最も代表的なN-アセチルノイラミン酸についてNeu5Ac特有の反応と基本的な反応の紹介と、簡単な反応によるNeu5Acの挙動からその化学的な多様性について述べる。
openaire +2 more sources
Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection
Advanced Genetics, Volume 7, Issue 1, March 2026.This review synthesizes current knowledge on the molecular mechanisms underpinning H5N1's host adaptation, focusing on key mutations in viral proteins. Critical mutations are discussed in detail, highlighting their roles in altering receptor specificity, promoting antiviral resistance, and expanding viral tropism. The review underscores the urgent need
Wenxin Man +7 more
wiley +1 more source
Sialic Acids as Receptors for Pathogens
Biomolecules, 2021 Carbohydrates have long been known to mediate intracellular interactions, whether within one organism or between different organisms. Sialic acids (Sias) are carbohydrates that usually occupy the terminal positions in longer carbohydrate chains, which ...
Patrycja Burzyńska +4 more
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Sialylation patterns in cerebral amyloid angiopathy
Brain Pathology, Volume 36, Issue 2, March 2026.This study is the first to localize and evaluate sialylation modifications in the context of Alzheimer's Disease and Cerebral Amyloid Angiopathy, revealing a unique disease‐specific increase in intravascular sialylation. Abstract Glycosylation is the most common form of post‐translational modification in the brain and becomes significantly altered in ...
Caitlyn Fastenau +8 more
wiley +1 more source
Crystal structure of 8,9-O-isopropylidine-Neu5Ac-methylester-methylketoside, C16H27NO9
Zeitschrift für Kristallographie - New Crystal Structures, 2012 C16H27NO9, monoclinic, C2 (no. 5), a = 22.868(3) Å, b = 6.1707(7) Å, c = 17.334(2) Å, β = 126.834(1)°, V = 1957.7 Å3, Z = 4, Rgt(F) = 0.0554, wRref(F2) = 0.1611, T = 293 ...
Yang Wei +4 more
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Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc [PDF]
Genome Biology and Evolution, 2017 The enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH) is responsible for the synthesis of N-glycolylneuraminic acid (Neu5Gc), a sialic acid present on the cell surface proteins of most deuterostomes. The CMAH gene is thought to be present in most deuterostomes, but it has been inactivated in a number of lineages, including humans.
Peri, Sateesh +4 more
openaire +4 more sources