Results 91 to 100 of about 4,193,744 (287)
Vestibular Pharmacology and Neural Pathway
Practica Oto-Rhino-Laryngologica, 1983 This paper deals with recent advances in anatomical, biochemical, pharmacological and physiological studies on the vestibular system. Fiber connections and characteristics of the vestibular neurons and primary vestibular neurons were discussed in relation to other structures such as the cerebellum, oculomotor nuclei, reticular formation, and spinal ...
Izuru Matsuoka +4 more
openaire +2 more sources
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
Complexity, 2018 Phasic activity of dopaminergic (DA) neurons in the ventral tegmental area or substantia nigra compacta (VTA/SNc) has been suggested to encode reward-prediction error signal for reinforcement learning. Recent studies have shown that the lateral habenula (
Huanyuan Zhou +2 more
doaj +1 more source
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source
Bypassing stroke-damaged neural pathways via a neural interface induces targeted cortical adaptation
Nature Communications, 2019 Monkeys were trained to use an artificial cortico-muscular connection (ACMC) to regain control over a paralyzed hand following subcortical stroke. Control over the paralyzed hand was accompanied by the appearance of localized high-gamma modulation in the
Kenji Kato +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source
The alexithymic brain: the neural pathways linking alexithymia to physical disorders
BioPsychoSocial Medicine, 2013 Alexithymia is a personality trait characterized by difficulties in identifying and describing feelings and is associated with psychiatric and psychosomatic disorders.
M. Kano, S. Fukudo
semanticscholar +1 more source
Central Neural Pathways Controlling Skeletal Muscle Shivering
Revista Cubana de Investigaciones Biomédicas, 2020 Introduction: Skeletal muscle shivering is the most important source of thermogenesis in the human cold-defensive maintenance of core body temperature (Tcore) and the elevated Tcore during fever. The thermoregulatory reflex pathway through which skin and
Shaun F. Morrison +1 more
doaj