Results 1 to 10 of about 210,754 (232)

Cutting-edge technologies in neural regeneration [PDF]

Cell Regeneration
Neural regeneration stands at the forefront of neuroscience, aiming to repair and restore function to damaged neural tissues, particularly within the central nervous system (CNS), where regenerative capacity is inherently limited.
Chang-Ping Li, Ying-Ying Wang, Ching-Wei Zhou, Chen-Yun Ding, Peng Teng, Rui Nie, Shu-Guang Yang   +6 more
doaj   +2 more sources

A Shift in Tissue Stiffness During Hippocampal Maturation Correlates to the Pattern of Neurogenesis and Composition of the Extracellular Matrix

Frontiers in Aging Neuroscience, 2021
Aging changes the mechanical properties of brain tissue, such as stiffness. It has been proposed that the maintenance and differentiation of neural stem cells (NSCs) are regulated in accordance with extracellular stiffness.
Youngjae Ryu, Misato Iwashita, Wonyoung Lee, Kenji Uchimura, Yoichi Kosodo   +4 more
doaj   +1 more source

A novel retinal ganglion cell quantification tool based on deep learning

Scientific Reports, 2021
Glaucoma is a disease associated with the loss of retinal ganglion cells (RGCs), and remains one of the primary causes of blindness worldwide. Major research efforts are presently directed towards the understanding of disease pathogenesis and the ...
Luca Masin, Marie Claes, Steven Bergmans, Lien Cools, Lien Andries, Benjamin M. Davis, Lieve Moons, Lies De Groef   +7 more
doaj   +1 more source

HSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury. [PDF]

JCI Insight, 2023
Huang Y, Meng S, Wu B, Shi H, Wang Y, Xiang J, Li J, Shi Z, Wu G, Lyu Y, Jia X, Hu J, Xu ZX, Gao Y.   +13 more
europepmc   +2 more sources

MMP2 Modulates Inflammatory Response during Axonal Regeneration in the Murine Visual System

Cells, 2021
Neuroinflammation has been put forward as a mechanism triggering axonal regrowth in the mammalian central nervous system (CNS), yet little is known about the underlying cellular and molecular players connecting these two processes.
Lien Andries, Luca Masin, Manuel Salinas-Navarro, Samantha Zaunz, Marie Claes, Steven Bergmans, Véronique Brouwers, Evy Lefevere, Catherine Verfaillie, Kiavash Movahedi, Lies De Groef, Lieve Moons   +11 more
doaj   +1 more source

Exogenous FGF-1 Differently Regulates Oligodendrocyte Replenishment in an SCI Repair Model and Cultured Cells

Biomedicines, 2022
We studied the phenotypes in an oligodendrocyte genesis site at the acute stage of spinal cord injury, when we observed regenerated ascending neurites. Pan-oligodendrocyte marker OLIG2+ cells were more in fibroblast growth factor (FGF)-1-treated rats (F ...
Meng-Jen Lee, May-Jywan Tsai, Wen-Chi Chang, Wang-Yu Hsu, Chien-Hui Hung, Ya-Tzu Chen, Tsung-Hsi Tu, Chih-Hung Shu, Ching-Jung Chen, Henrich Cheng   +9 more
doaj   +1 more source

The various routes to functional regeneration in the central nervous system [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Echeverri, K.
Echeverri, Karen
core   +1 more source

Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. [PDF]

, 2020
One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge.
Anderson, Aileen J, Ciciriello, Andrew J, Cummings, Brian J, Dumont, Courtney M, Guo, Amina, Park, Jonghyuck, Shea, Lonnie D, Smith, Dominique R, Tatineni, Ravindra   +8 more
core   +1 more source

Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes. [PDF]

, 2020
This review focuses on the role of the Cytochrome p450 subfamily 26 (CYP26) retinoic acid (RA) degrading enzymes during development and regeneration. Cyp26 enzymes, along with retinoic acid synthesising enzymes, are absolutely required for RA homeostasis
Roberts, C
core   +1 more source

Improving the regenerative potential of olfactory ensheathing cells by overexpressing prostacyclin synthetase and its application in spinal cord repair

Journal of Biomedical Science, 2017
Background Olfactory ensheathing cells (OEC), specialized glia that ensheathe bundles of olfactory nerves, have been reported as a favorable substrate for axonal regeneration.
May-Jywan Tsai, Chi-Ting Huang, Yong-San Huang, Ching-Feng Weng, Song-Kun Shyue, Ming-Chao Huang, Dann-Ying Liou, Yan-Ru Lin, Chu-Hsun Cheng, Huai-Sheng Kuo, Yilo Lin, Meng-Jen Lee, Wen-Hung Huang, Wen-Cheng Huang, Henrich Cheng   +14 more
doaj   +1 more source