Results 1 to 10 of about 113,891 (260)

NSUN5 as a Prognostic Biomarker Correlates with Malignant Phenotype and Therapeutic Target in Glioma

Brain and Behavior
Background NSUN5 is a conserved RNA methyltransferase whose oncogenic role has been demonstrated in various cancers. However, its function and prognostic value in gliomas remain unclear.
Ye Wenhao, Wu Huan, Zou Xiaoyun, Yang Yuanyuan, Bi Junlei, Liu Changqing, Zhao Mengyi, Zhang Yuyuan, Lu Jin, Wen Hebao, Ma Caiyun   +10 more
doaj   +1 more source

Subthalamic hGAD65 Gene Therapy and Striatum TH Gene Transfer in a Parkinson’s Disease Rat Model

Neural Plasticity, 2013
The aim of the present study is to detect a combination method to utilize gene therapy for the treatment of Parkinson’s disease (PD). Here, a PD rat model is used for the in vivo gene therapy of a recombinant adeno-associated virus (AAV2) containing a ...
Deyu Zheng, Xiaohua Jiang, Junpeng Zhao, Deyi Duan, Huanying Zhao, Qunyuan Xu   +5 more
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Fibrotic scarring prevents optic nerve regeneration despite preserved axonal growth potential in adult killifish

Frontiers in Neuroscience
Adult mammals exhibit limited regenerative capacity in the central nervous system (CNS), leading to irreversible deficits following injury or disease. Effective strategies to restore CNS function remain lacking.
Julie D. De Schutter, Luca Masin, Anyi Zhang, Lieve Moons, Steven Bergmans   +4 more
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Genetic Identification of Potential Drug Targets for Dental Caries: A Mendelian Randomization Study

Health Science Reports
Background and Aims Dental caries (DC), a chronic and multifactorial disease, affects billions of people globally, posing a significant public health challenge.
Junlei Bi, Anqi Liu, Na Zhang, Yuxin Chen, Changqing Liu, Yongna Zhu, Hebao Wen, Caiyun Ma   +7 more
doaj   +1 more source

Cyclin-dependent kinase inhibitor p18 regulates lineage transitions of excitatory neurons, astrocytes, and interneurons in the mouse cortex

The EMBO Journal
Neural stem cells (NSCs) can give rise to both neurons and glia, but the regulatory mechanisms governing their differentiation transitions remain incompletely understood.
Wonyoung Lee, Byunghee Kang, Hyo-Min Kim, Tsuyoshi Ishida, Minkyung Shin, Misato Iwashita, Masahiro Nitta, Aki Shiraishi, Hiroshi Kiyonari, Koichiro Shimoya, Kazuto Masamoto, Tae-Young Roh, Yoichi Kosodo   +12 more
doaj   +1 more source

Establishment of transgenic fluorescent mice for labeling synapses and screening synaptogenic adhesion molecules

eLife
Synapse is the fundamental structure for neurons to transmit information between cells. The proper synapse formation is crucial for developing neural circuits and cognitive functions of the brain.
Lei Yang, Jingtao Zhang, Sen Liu, Yanning Zhang, Li Wang, Xiaotong Wang, Shanshan Wang, Ke Li, Mengping Wei, Chen Zhang   +9 more
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Bibliometric and visualization analysis of arginine deiminase research from 2006 to 2025: trends, collaboration networks and emerging frontiers

Frontiers in Immunology
BackgroundPeptidylarginine Deiminase/Protein Arginine Deiminase (PAD/PADI) are a family of enzymes that catalyze protein citrullination, converting arginine residues to citrulline residues in a calcium-dependent manner. The net loss of positive charge of
Songtao Jiang, Lebin Gan, Qiang Wang, Guozheng Cao, Zhuang Zhang, Feifei Jin, Jing Zhou, Panpan Chang, Tianbing Wang, Jingjing Ye   +9 more
doaj   +1 more source

Disruption of a GalR2–mitochondrial axis in the ventral hippocampus contributes to depression-like phenotypes after prenatal stress

Frontiers in Psychiatry
BackgroundPrenatal stress (PS) is a major risk factor for depression later in life, yet the cellular mechanisms linking early-life adversity to long-term affective vulnerability remain incompletely understood.
Jingjing Yue, Jing Zhang, Xiaoyi Yu, Zhiheng Li, Yanhua Wang, Siyi Zhao, Yunfei Bai, Xiaoxiao Li, Hui Li, Yutao Yang, Zhi-Qing David Xu, Zhi-Qing David Xu   +11 more
doaj   +1 more source

LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons

Protein & Cell, 2020
Fang Yuan, Kai-Heng Fang, Yuan Hong, Shi-Bo Xu, Min Xu, Yufeng Pan, Yan Liu   +6 more
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Protocol for differentiating human pluripotent stem cells into midbrain organoids for targeted microinjection of viruses

STAR Protocols
Summary: Midbrain organoids serve as a valuable model for studying brain development and disease. Here, we present a viral infection protocol for midbrain organoid models.
Mengdan Tao, Qi Chen, WeiWei Gao, Shanshan Wu, Yan Liu   +4 more
doaj   +1 more source