Results 1 to 10 of about 344,220 (168)

A Shift in Tissue Stiffness During Hippocampal Maturation Correlates to the Pattern of Neurogenesis and Composition of the Extracellular Matrix

Frontiers in Aging Neuroscience, 2021
Aging changes the mechanical properties of brain tissue, such as stiffness. It has been proposed that the maintenance and differentiation of neural stem cells (NSCs) are regulated in accordance with extracellular stiffness.
Youngjae Ryu, Misato Iwashita, Wonyoung Lee, Kenji Uchimura, Yoichi Kosodo   +4 more
doaj   +1 more source

A novel retinal ganglion cell quantification tool based on deep learning

Scientific Reports, 2021
Glaucoma is a disease associated with the loss of retinal ganglion cells (RGCs), and remains one of the primary causes of blindness worldwide. Major research efforts are presently directed towards the understanding of disease pathogenesis and the ...
Luca Masin, Marie Claes, Steven Bergmans, Lien Cools, Lien Andries, Benjamin M. Davis, Lieve Moons, Lies De Groef   +7 more
doaj   +1 more source

MMP2 Modulates Inflammatory Response during Axonal Regeneration in the Murine Visual System

Cells, 2021
Neuroinflammation has been put forward as a mechanism triggering axonal regrowth in the mammalian central nervous system (CNS), yet little is known about the underlying cellular and molecular players connecting these two processes.
Lien Andries, Luca Masin, Manuel Salinas-Navarro, Samantha Zaunz, Marie Claes, Steven Bergmans, Véronique Brouwers, Evy Lefevere, Catherine Verfaillie, Kiavash Movahedi, Lies De Groef, Lieve Moons   +11 more
doaj   +1 more source

Exogenous FGF-1 Differently Regulates Oligodendrocyte Replenishment in an SCI Repair Model and Cultured Cells

Biomedicines, 2022
We studied the phenotypes in an oligodendrocyte genesis site at the acute stage of spinal cord injury, when we observed regenerated ascending neurites. Pan-oligodendrocyte marker OLIG2+ cells were more in fibroblast growth factor (FGF)-1-treated rats (F ...
Meng-Jen Lee, May-Jywan Tsai, Wen-Chi Chang, Wang-Yu Hsu, Chien-Hui Hung, Ya-Tzu Chen, Tsung-Hsi Tu, Chih-Hung Shu, Ching-Jung Chen, Henrich Cheng   +9 more
doaj   +1 more source

6’-sialyllactose ameliorates the ototoxic effects of the aminoglycoside antibiotic neomycin in susceptible mice

Frontiers in Immunology, 2023
Sialic acids are terminal sugars of the cellular glycocalyx and are highly abundant in the nervous tissue. Sialylation is sensed by the innate immune system and acts as an inhibitory immune checkpoint.
Tawfik Abou Assale, Thomas Kuenzel, Tamara Schink, Anahita Shahraz, Harald Neumann, Christine Klaus   +5 more
doaj   +1 more source

NLRP3 deficiency decreases alcohol intake controlling anxiety-like behavior via modification of glutamatergic transmission in corticostriatal circuits

Journal of Neuroinflammation, 2022
Background Alcohol use disorders result from repeated binge and chronic alcohol consumption followed by negative effects, such as anxiety, upon cessation. This process is associated with the activation of NLRP3 inflammasome-mediated responses.
Ziyi Li, Olivia Ewi Vidjro, Gengni Guo, Yanfeng Du, Yao Zhou, Qian Xie, Jiaxin Li, Keqiang Gao, Li Zhou, Tengfei Ma   +9 more
doaj   +1 more source

Determinants of Increased Fibrinogen in COVID-19 Patients With and Without Diabetes and Impaired Fasting Glucose

Clinical and Applied Thrombosis/Hemostasis, 2021
Background: To investigate the factors associated with elevated fibrinogen (Fbg) levels in COVID-19 patients with and without diabetes (DM) and impaired fasting glucose (IFG).
Zhenzhou Wang MD, Zhe Du MD, Xiujuan Zhao MD, Fuzheng Guo MD, Tianbing Wang MD, Fengxue Zhu MD   +5 more
doaj   +1 more source

Characterizing the Retinal Phenotype of the Thy1-h[A30P]α-syn Mouse Model of Parkinson’s Disease

Frontiers in Neuroscience, 2021
Despite decades of research, disease-modifying treatments of Parkinson’s disease (PD), the second most common neurodegenerative disease worldwide, remain out of reach.
Lien Veys, Lien Veys, Joyce Devroye, Joyce Devroye, Evy Lefevere, Evy Lefevere, Lien Cools, Lien Cools, Marjan Vandenabeele, Marjan Vandenabeele, Lies De Groef, Lies De Groef   +11 more
doaj   +1 more source

Improving the regenerative potential of olfactory ensheathing cells by overexpressing prostacyclin synthetase and its application in spinal cord repair

Journal of Biomedical Science, 2017
Background Olfactory ensheathing cells (OEC), specialized glia that ensheathe bundles of olfactory nerves, have been reported as a favorable substrate for axonal regeneration.
May-Jywan Tsai, Chi-Ting Huang, Yong-San Huang, Ching-Feng Weng, Song-Kun Shyue, Ming-Chao Huang, Dann-Ying Liou, Yan-Ru Lin, Chu-Hsun Cheng, Huai-Sheng Kuo, Yilo Lin, Meng-Jen Lee, Wen-Hung Huang, Wen-Cheng Huang, Henrich Cheng   +14 more
doaj   +1 more source

Hyaluronan, neural stem cells and tissue reconstruction after acute ischemic stroke. [PDF]

, 2013
Focal stroke is a disabling disease with lifelong sensory, motor and cognitive impairments. Given the paucity of effective clinical treatments, basic scientists are developing novel options for protection of the affected brain and regeneration of lost ...
Carmichael, S Thomas, Moshayedi, Pouria
core   +1 more source