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Neural stem cells [PDF]

open access: yesBone Marrow Transplantation, 2003
The adult vertebrate central nervous system (CNS) consists of four major differentiated cell types: neurons, astrocytes, oligodendrocytes and ependymal cells. Historically, there has been a disagreement on how these differentiated cell types are generated in the CNS. Progress remains hindered by the complexity of cell structure in this system, the lack
GALLI R.   +3 more
  +8 more sources

Neural stem cells [PDF]

open access: yesThe Journal of Pathology, 2002
AbstractNeural stem cells (NSCs) have the ability to self‐renew, and are capable of differentiating into neurones, astrocytes and oligodendrocytes. Such cells have been isolated from the developing brain and more recently from the adult central nervous system. This review aims to provide an overview of the current research in this evolving area.
Nigel L, Kennea, Huseyin, Mehmet
  +5 more sources

Does the plasticity of neural stem cells and neurogenesis make them biosensors of disease and damage?

open access: yesFrontiers in Neuroscience, 2022
Postnatal and adult neurogenesis takes place in the dentate gyrus of the hippocampus in the vast majority of mammals due to the persistence of a population of neural stem cells (NSCs) that also generate astrocytes and more NSCs.
Ane Rodríguez-Bodero   +4 more
doaj   +1 more source

LPS-Induced Systemic Inflammation Affects the Dynamic Interactions of Astrocytes and Microglia with the Vasculature of the Mouse Brain Cortex

open access: yesCells, 2023
The Neurovascular Unit (NVU), composed of glia (astrocytes, oligodendrocytes, microglia), neurons, pericytes and endothelial cells, is a dynamic interface ensuring the physiological functioning of the central nervous system (CNS), which gets affected and
Evangelia Xingi   +8 more
doaj   +1 more source

Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2

open access: yesThe EMBO Journal, 2023
Lifelong hippocampal neurogenesis is maintained by a pool of multipotent adult neural stem cells (aNSCs) residing in the subgranular zone of the dentate gyrus (DG).
Oier Pastor-Alonso   +11 more
doaj   +1 more source

Neural stem cells

open access: yesCurrent Opinion in Neurobiology, 2001
In recent papers on neural stem cells, two areas of progress stand out. First, there has been a substantial growth in the published examples of 'transdifferentiation'. Second, there has been progress, albeit more modest, in studies of repair by neural stem cells following transplantation into animal models of disease.
Price, J, Williams, B P
  +8 more sources

Human neural stem cells

open access: yesCell Proliferation, 2023
Abstract‘Human neural stem cells’ jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research, is the first guideline for human neural stem cells (hNSCs) in China. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements ...
Yu‐Kai Wang   +30 more
openaire   +2 more sources

Long-term calcium imaging reveals functional development in hiPSC-derived cultures comparable to human but not rat primary cultures

open access: yesStem Cell Reports, 2023
Summary: Models for human brain-oriented research are often established on primary cultures from rodents, which fails to recapitulate cellular specificity and molecular cues of the human brain.
Estefanía Estévez-Priego   +5 more
doaj   +1 more source

A three-dimensional matrix system containing melatonin and neural stem cells repairs damage from traumatic brain injury in rats

open access: yesNeural Regeneration Research, 2022
[INLINE:1] Brain lesions can cause neural stem cells to activate, proliferate, differentiate, and migrate to the injured area. However, after traumatic brain injury, brain tissue defects and microenvironment changes greatly affect the survival and growth
Xuan-Yu Fang   +8 more
doaj   +1 more source

Effects of primary microglia and astrocytes on neural stem cells in in vitro and in vivo models of ischemic stroke

open access: yesNeural Regeneration Research, 2021
Transplantation of neural stem cells (NSCs) can protect neurons in animal stroke models; however, their low rates of survival and neuronal differentiation limit their clinical application.
Sheng-Jun Wen   +6 more
doaj   +1 more source

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