Results 21 to 30 of about 1,237,621 (358)
Stem Cells International, 2012 Pluripotent stem cells are regarded as a promising cell source to obtain human dopamine neurons in sufficient amounts and purity for cell replacement therapy.
Julio C. Aguila +2 more
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Frontiers in Physiology, 2019 Dental pulp stem cells (DPSCs) have the capacity to give rise to cells with neuronal-like phenotypes, suggesting their use in brain cell therapies. In the present work, we wanted to address the phenotypic fate of adult genetically unmodified human DPSCs ...
Jon Luzuriaga +7 more
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Transcriptional profiling of adult neural stem-like cells from the human brain. [PDF]
PLoS ONE, 2014 There is a great potential for the development of new cell replacement strategies based on adult human neural stem-like cells. However, little is known about the hierarchy of cells and the unique molecular properties of stem- and progenitor cells of the ...
Cecilie Jonsgar Sandberg +4 more
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eLife, 2018 Human GABAergic interneurons (GIN) are implicated in normal brain function and in numerous mental disorders. However, the generation of functional human GIN subtypes from human pluripotent stem cells (hPSCs) has not been established.
Fang Yuan +11 more
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Cancer stem cells display extremely large evolvability: alternating plastic and rigid networks as a potential mechanism [PDF]
Seminars in Cancer Biology 30 (2015) 42-51, 2013 Cancer is increasingly perceived as a systems-level, network phenomenon. The major trend of malignant transformation can be described as a two-phase process, where an initial increase of network plasticity is followed by a decrease of plasticity at late stages of tumor development. The fluctuating intensity of stress factors, like hypoxia, inflammation
arxiv +1 more source
Mechanically-driven Stem Cell Separation in Tissues caused by Proliferating Daughter Cells [PDF]
SciPost Phys. 16, 097 (2024), 2023 The homeostasis of epithelial tissue relies on a balance between the self-renewal of stem cell populations, cellular differentiation, and loss. Although this balance needs to be tightly regulated to avoid pathologies, such as tumor growth, the regulatory mechanisms, both cell-intrinsic and collective, which ensure tissue steady-state are still poorly ...
arxiv +1 more source
The stem cells of the neural crest [PDF]
Cell Cycle, 2008 In the vertebrate embryo, the neurectodermal neural crest cells (NCC) have remarkably broad potencies, giving rise, after a migratory phase, to neurons and glial cells in the peripheral nervous system, and to skin melanocytes, being all designated here as "neural" derivatives.
Nicole M. Le Douarin +2 more
openaire +3 more sources
Fast and Efficient Neural Conversion of Human Hematopoietic Cells
Stem Cell Reports, 2014 Neurons obtained directly from human somatic cells hold great promise for disease modeling and drug screening. Available protocols rely on overexpression of transcription factors using integrative vectors and are often slow, complex, and inefficient.
Julio Castaño +14 more
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Mathematics, 2020 In this paper, we study the interactions between microglia and neural stem cells and the impact of these interactions on the brain cells during a stroke.
Awatif Jahman Alqarni +2 more
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Characterization of TLX expression in neural stem cells and progenitor cells in adult brains. [PDF]
PLoS ONE, 2012 TLX has been shown to play an important role in regulating the self-renewal and proliferation of neural stem cells in adult brains. However, the cellular distribution of endogenous TLX protein in adult brains remains to be elucidated.
Shengxiu Li +4 more
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