Results 61 to 70 of about 7,655 (179)
Communications BiologySeveral bacterial flagellins are O-glycosylated with nonulosonic acids on surface-exposed Serine/Threonine residues by Maf glycosyltransferases. The Clostridium botulinum Maf glycosyltransferase (CbMaf) displays considerable donor substrate promiscuity ...
Sonali Sunsunwal +3 more
doaj +1 more source
Neuraminic acid content of sputum in chronic bronchitis [PDF]
Thorax, 1972 The neuraminic acid content of sputum from 48 men with early chronic bronchitis has been estimated in samples collected over a period of three years. The results are compared with those from 29 advanced bronchitic patients and are related to the clinical features of both groups and to the physical and biological properties of the sputum.
E E, Keal, L, Reid
openaire +2 more sources
Toward the Synthesis of 3,3‐Difluoro Deaminated Sialic Acid (C3DFKDN)
European Journal of Organic Chemistry, Volume 28, Issue 30, August 19, 2025.The synthesis of protected C3‐difluoro KDN (C3DFKDN), an unnatural derivative of the sialic acid member, KDN, and key building block for KDN‐based chemical probes, is reported. Its 12‐step synthetic route starts from commercially available methyl d‐mannopyranoside and key steps include a Reformatsky reaction with ethyl bromodifluoroacetate, alkylation ...
Lemeng Chao, Tom Wennekes
wiley +1 more source
Polysialosides Outperform Sulfated Analogs for Binding with SARS‐CoV‐2
Small, Volume 21, Issue 34, August 28, 2025.Both sulfated and sialylated glycans present on the cell surface act as co‐receptors for the SARS‐CoV‐2 attachment. Polysialylated and sulfated dendritic polyglycerols are studied for their binding with SARS‐CoV‐2. In solution, dendritic polyglycerol sialosides (dPGSAs) bind significantly stronger (low nm) to SARS‐CoV‐2 than their sulfated analogs ...
Vinod Khatri +16 more
wiley +1 more source
Iron-binding fragments from the N-Terminal and C-Terminal regions of human lactoferrin [PDF]
, 1978 Digestion of lactoferrin with pepsin at pH 3.0 gave an iron-binding half-molecule that represents the C-terminal part of the native protein. Tryptic or chymotryptic digestion of 30%/-iron-saturated lactoferrin yielded the N- and C-terminal half ...
Bluard-Deconinck, JM +5 more
core +1 more source
Gut Microbiota Composition and Modulation in Developmental and Epileptic Encephalopathies
European Journal of Neuroscience, Volume 62, Issue 4, August 2025.Clinical studies link gut microbiota (GM) composition to adrenocorticotropic hormone (ACTH) treatment response. In infantile epileptic spasms syndrome (IESS) mouse models, GM modulation via antibiotics, ketogenic diet (KD), fecal transplantation, or probiotics reduced epileptic spasms, while in Dravet syndrome (DS) models, the KD showed no anti‐seizure
Takwa Ammar +3 more
wiley +1 more source
Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection. [PDF]
, 2019 Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis.
Barnard, Karen N +10 more
core +3 more sources
EFSA Journal, Volume 23, Issue 8, August 2025.Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on lacto‐N‐tetraose (LNT) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is mainly composed of the human‐identical milk oligosaccharide (HiMO) LNT, but it also contains lacto‐N ...
EFSA Panel on Nutrition +30 more
wiley +1 more source
Koenigs-Knorr Glycosylation with Neuraminic Acid Derivatives [PDF]
International Journal of Carbohydrate Chemistry, 2010 Earlier we reported a convenient and efficient method of preparing α2-6 sialooligosaccharides in conditions of Koenigs-Knorr reaction. The use of Ag2CO3 allowed carrying out α2-6 sialylation of galacto-4,6-diol of mono- and disaccharides with chloride of acetylated N-acetylneuraminic acid methyl ester as glycosyl donor.
Galina Pazynina +6 more
openaire +1 more source
JIMD Reports, Volume 66, Issue 4, July 2025.Schematic illustrating the study design and key findings. Figure created in Biorender.com. ABSTRACT Lysosomal free sialic acid storage disorder (FSASD) is a rare, multisystem neurodegenerative disease caused by biallelic pathogenic variants in SLC17A5, encoding sialin.
Marya S. Sabir +9 more
wiley +1 more source