Results 61 to 70 of about 4,989,359 (237)

Harnessing the acceptor substrate promiscuity of Clostridium botulinum Maf glycosyltransferase to glyco-engineer mini-flagellin protein chimeras

open access: yesCommunications Biology
Several bacterial flagellins are O-glycosylated with nonulosonic acids on surface-exposed Serine/Threonine residues by Maf glycosyltransferases. The Clostridium botulinum Maf glycosyltransferase (CbMaf) displays considerable donor substrate promiscuity ...
Sonali Sunsunwal   +3 more
doaj   +1 more source

A search for mid-IR bands of amino acids in the Perseus Molecular Cloud [PDF]

open access: yesarXiv, 2021
Amino acids are building-blocks of proteins, basic constituents of all organisms and essential to life on Earth. They are present in carbonaceous chondrite meteorites and comets, but their origin is still unknown. Formation of amino acids in the interstellar medium is posible via specific gas-phase reactions in dark clouds, however sensitive ...
arxiv  

Large presence of carbonic acid in CO$_2$-rich aqueous fluids under Earth's mantle conditions [PDF]

open access: yesJournal of Physical Chemistry Letters 10, 5135-5141 (2019), 2019
The chemistry of carbon in aqueous fluids at extreme pressure and temperature conditions is of great importance to Earth's deep carbon cycle, which substantially affects the carbon budget at Earth's surface and global climate change. At ambient conditions, the concentration of carbonic acid in water is negligible, so aqueous carbonic acid was simply ...
arxiv   +1 more source

Tumor‐Associated Carbohydrate Antigen 19–9 (CA 19–9), a Promising Target for Antibody‐Based Detection, Diagnosis, and Immunotherapy of Cancer

open access: yesChemMedChem, Volume 19, Issue 24, December 16, 2024.
Carbohydrate antigen 19–9 (CA 19–9), also known as sialyl Lewis A, is a tetrasaccharide overexpressed on a wide range of cancerous cells, most prominently pancreatic ductal adenocarcinoma. The review discusses the synthesis of CA 19–9, elicitation of antibodies through vaccination, development of anti‐CA 19–9 monoclonal antibodies, and their ...
Athar Nakisa   +6 more
wiley   +1 more source

Acid zeta function and ajoint acid zeta function [PDF]

open access: yesarXiv, 2010
In this paper we set up the theory of acid zeta function and ajoint acid zeta function, based on the theory, we point out a reason to doubt the truth of the Riemann hypothesis and also as a consequence, we give out some new RH equivalences.
arxiv  

Streptococcus pneumoniae Sialidase SpNanB-Catalyzed One-Pot Multienzyme (OPME) Synthesis of 2,7-Anhydro-Sialic Acids as Selective Sialidase Inhibitors.

open access: yesJournal of Organic Chemistry, 2018
Streptococcus pneumoniae sialidase SpNanB is an intramolecular trans-sialidase (IT-sialidase) and a virulence factor that is essential for streptococcal infection of the upper and lower respiratory tract.
An Xiao   +7 more
semanticscholar   +1 more source

Detection Strategies for Sialic Acid and Sialoglycoconjugates

open access: yesChemBioChem, Volume 25, Issue 23, December 2, 2024.
Sialic acid is a glycan residue found at the termini of many glycoconjugates. This residue, and the underlying residues it covers, form critical recognition epitopes in glycobiology. In this review we discuss methods to detect sialoglycoconjugates and sialic acids which are either substrates or products of the enzymes that form these conjugates ...
Carmanah D. Hunter, Christopher W. Cairo
wiley   +1 more source

Is Amino-Acid Homochirality Due To Asymmetric Photolysis In Space? [PDF]

open access: yesarXiv, 1999
Amino acids occurring in proteins are, with rare exceptions, exclusively of the L-configuration. Among the many scenarios put forward to explain the origin of this chiral homogeneity (i.e., homochirality), one involves the asymmetric photolysis of amino acids present in space, triggered by circularly polarized UV radiation.
arxiv  

Exploiting Archaeal/Thermostable Enzymes in Synthetic Chemistry: Back to the Future?

open access: yesChemCatChem, Volume 16, Issue 21, November 11, 2024.
Thermostable and (hyper)thermophilic enzymes offer important opportunities for innovative, stereoselective and sustainable chemistry transformations. Many of these are archaeal enzymes that have evolved to operate under extreme conditions, including at elevated temperature.
Gaurav P. Kudalkar   +2 more
wiley   +1 more source

Are Strong Bronsted Acids Necessarily Strong Lewis Acids? [PDF]

open access: yesarXiv, 2006
The Broensted and Lowry acid base theory is based on the capacity of proton donation or acceptance (in the presence or absence of a solvent) whereas the Lewis acid base theory is based on the propensity of electron pair acceptance or donation. We explore through DFT calculation the obvious question whether these two theories are in conformity with each
arxiv  

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