Origin of Neuraminic Acid in Human Seminal Fluid [PDF]
THE occurrence and possible function of the neuraminic acids in mammalian tissues and fluids is a matter of great interest. Large amounts of N-acetylneuraminic acid have been demonstrated in the seminal fluid of man1,2, bull3 and boar4. Analysis of the secretions of the accessory genital organs of the boar showed that the mucin from the bulbourethral ...
openaire +2 more sources
Beyond FimH: Diversity and Relevance of Carbohydrate‐Binding Fimbrial Proteins in Escherichia coli
This review discusses fimbrial lectins found in Escherichia coli (E. coli) other than FimH, which could be targeted to treat E. coli pathogenicity as an alternative to antibiotic treatment. Escherichia coli (E. coli) is responsible for multiple diseases in humans and animals.
Oliwier R. Dulawa +3 more
wiley +1 more source
Neuraminic Acid as a Constituent of Human Cerebrospinal Fluid.
Conclusions1. The neuraminic acid (NA) content of 49 samples of human cerebrospinal fluid (CSF) was studied. In all instances the quantitative relationship of neuraminic acid to the cerebrospinal fluid protein was far in excess of that prevalent in serum.
M K, RUMLEY, L L, UZMAN
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Nanomaterial‐Based Optical Biosensors for SARS‐CoV‐2 Detection: A Retrospective of the Pandemic
This review discusses nanomaterial‐based optical biosensors developed for or adapted to the detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). It concludes by providing a perspective on how lessons learned during the coronavirus disease of 2019 (COVID‐19) pandemic may be applied for future research on nanomaterial‐based ...
Flavie Martin +2 more
wiley +1 more source
Toward the Synthesis of 3,3‐Difluoro Deaminated Sialic Acid (C3DFKDN)
The synthesis of protected C3‐difluoro KDN (C3DFKDN), an unnatural derivative of the sialic acid member, KDN, and key building block for KDN‐based chemical probes, is reported. Its 12‐step synthetic route starts from commercially available methyl d‐mannopyranoside and key steps include a Reformatsky reaction with ethyl bromodifluoroacetate, alkylation ...
Lemeng Chao, Tom Wennekes
wiley +1 more source
Polysialosides Outperform Sulfated Analogs for Binding with SARS‐CoV‐2
Both sulfated and sialylated glycans present on the cell surface act as co‐receptors for the SARS‐CoV‐2 attachment. Polysialylated and sulfated dendritic polyglycerols are studied for their binding with SARS‐CoV‐2. In solution, dendritic polyglycerol sialosides (dPGSAs) bind significantly stronger (low nm) to SARS‐CoV‐2 than their sulfated analogs ...
Vinod Khatri +16 more
wiley +1 more source
Lactic acid bacteria isolated from poultry protect the intestinal epithelial cells of chickens from in vitro wheat germ agglutinin-induced cytotoxicity [PDF]
Poultry fed on wheat-based diets regularly ingest wheat germ agglutinin (WGA) that has toxic effects in vitro on intestinal epithelial cells (IEC) obtained from 14-d-old broilers.
Apella, Maria Cristina +4 more
core +1 more source
Gut Microbiota Composition and Modulation in Developmental and Epileptic Encephalopathies
Clinical studies link gut microbiota (GM) composition to adrenocorticotropic hormone (ACTH) treatment response. In infantile epileptic spasms syndrome (IESS) mouse models, GM modulation via antibiotics, ketogenic diet (KD), fecal transplantation, or probiotics reduced epileptic spasms, while in Dravet syndrome (DS) models, the KD showed no anti‐seizure
Takwa Ammar +3 more
wiley +1 more source
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on lacto‐N‐tetraose (LNT) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is mainly composed of the human‐identical milk oligosaccharide (HiMO) LNT, but it also contains lacto‐N ...
EFSA Panel on Nutrition +30 more
wiley +1 more source
A structural and functional model for human bone sialoprotein [PDF]
Human bone sialoprotein (BSP) is an essential component of the extracellular matrix of bone. It is thought to be the primary nucleator of hydroxyapatite crystallization, and is known to bind to hydroxyapatite, collagen, and cells.
Durrant, Marcus, Vincent, Kevin
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