Results 41 to 50 of about 45,170 (239)

Detection of Neuraminidase Activity in Pseudomonas aeruginosa PAO1 [PDF]

Iranian Journal of Basic Medical Sciences, 2010
Objective(s)Some properties of neuraminidase produced by Pseudomonas aeruginosa PAO1 growth in a defined medium (BHI) were examined and evaluated for its features.Materials and MethodsThe obtained supernatant enzyme of P.
Ciamak Ghazaei, Malahat Ahmadi, Nima Hosseini Jazani   +2 more
doaj  

Beyond the Biological Effect of a Chemically Characterized Poplar Propolis: Antibacterial and Antiviral Activity and Comparison with Flurbiprofen in Cytokines Release by LPS-Stimulated Human Mononuclear Cells

Biomedicines, 2019
Bee propolis, especially Euro-Asian poplar propolis, is among the most well-known natural products traditionally used to treat pharyngitis and minor wounds. The aim of this research was to investigate the pharmacological properties responsible for poplar
Paolo Governa, Maria Grazia Cusi, Vittoria Borgonetti, José Mauricio Sforcin, Chiara Terrosi, Giulia Baini, Elisabetta Miraldi, Marco Biagi   +7 more
doaj   +1 more source

A Cross-Reactive Monoclonal Antibody Against Neuraminidases of Both H9N2 and H3N2 Influenza Viruses Shows Protection in Mice Challenging Models

Frontiers in Microbiology, 2021
Neuraminidases (NAs) of H9N2 avian influenza virus (AIV) and H3N2 human seasonal influenza virus (HSIV) share similar antigenic structures. However, there are few reports on epitopes shared by these two NAs.
Fei Wang, Fei Wang, Zhimin Wan, Zhimin Wan, Zhimin Wan, Jinsen Wu, Jinsen Wu, Yajuan Wang, Yajuan Wang, Hui Fu, Hui Fu, Hongxia Shao, Hongxia Shao, Hongxia Shao, Kun Qian, Kun Qian, Kun Qian, Wei Gao, Wei Gao, Wei Gao, Jianqiang Ye, Jianqiang Ye, Jianqiang Ye, Aijian Qin, Aijian Qin, Aijian Qin   +25 more
doaj   +1 more source

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada

Emerging Infectious Diseases, 2019
We identified an influenza B isolate harboring a Gly407Ser neuraminidase substitution in an immunocompromised patient in Canada before antiviral therapy.
Yacine Abed, Clément Fage, Patrick Lagüe, Julie Carbonneau, Jesse Papenburg, Donald C. Vinh, Guy Boivin   +6 more
doaj   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Characterization of H5N1 influenza A virus that caused the first highly pathogenic avian influenza outbreak in Saudi Arabia

Journal of Infection in Developing Countries, 2015
Introduction: Saudi Arabia (SA) experienced a highly pathogenic avian influenza (HPAI) H5N1 outbreak in domesticated birds in 2007. Methodology: Forty-three hemagglutinin (HA) and 41 neuraminidase (NA) genes of HPAI H5N1 viruses were sequenced and ...
Ahmed Ali Al-Qahtani, Muhammad Mubin, Fahad N. Almajhdi, Saud Alarifi, Damian M. dela Cruz, Muhammad Shah Nawaz ul Rehman, Mahmoud Moussa Ismail, Nisar Ahmed, Mohamed H. Al-Blowi, Hanif Khalak, Mohammed N. Al-Ahdal   +10 more
doaj   +1 more source

Multiple Neuraminidase Containing Influenza Virus-like Particle Vaccines Protect Mice from Avian and Human Influenza Virus Infection

Viruses, 2022
Avian influenza virus remains a threat for humans, and vaccines preventing both avian and human influenza virus infections are needed. Since virus-like particles (VLPs) expressing single neuraminidase (NA) subtype elicited limited heterosubtypic ...
Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Min-Ju Kim, Su-Hwa Lee, Eun-Kyung Moon, Fu-Shi Quan   +8 more
doaj   +1 more source

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Optimized production of a truncated form of the recombinant neuraminidase of influenza virus in Escherichia coli as host with suitable functional activity

Microbial Cell Factories
Background To discover effective drugs for treating Influenza (a disease with high annual mortality), large amounts of recombinant neuraminidase (NA) with suitable catalytic activity are needed. However, the functional activity of the full-length form of
Fatemeh Sadat Shariati, Fatemeh Fotouhi, Behrokh Farahmand, Zahra Barghi, Kayhan Azadmanesh   +4 more
doaj   +1 more source