Results 51 to 60 of about 43,769 (228)

Detection of Neuraminidase Activity in Pseudomonas aeruginosa PAO1 [PDF]

Iranian Journal of Basic Medical Sciences, 2010
Objective(s)Some properties of neuraminidase produced by Pseudomonas aeruginosa PAO1 growth in a defined medium (BHI) were examined and evaluated for its features.Materials and MethodsThe obtained supernatant enzyme of P.
Ciamak Ghazaei, Malahat Ahmadi, Nima Hosseini Jazani   +2 more
doaj  

Neuraminidase (NA) 370-Loop Mutations of the 2009 Pandemic H1N1 Viruses Affect NA Enzyme Activity, Hemagglutination Titer, Mouse Virulence, and Inactivated-Virus Immunogenicity

Viruses, 2022
Hemagglutinin (HA) and neuraminidase (NA) are the two major envelope proteins of influenza viruses. The spatial organization of HA and NA on the virus surface needs to be optimized to promote viral fitness, host specificity, transmissibility, infectivity,
Ting-Hsuan Chen, Chung-Chu Chen, Suh-Chin Wu   +2 more
doaj   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Optimized production of a truncated form of the recombinant neuraminidase of influenza virus in Escherichia coli as host with suitable functional activity

Microbial Cell Factories
Background To discover effective drugs for treating Influenza (a disease with high annual mortality), large amounts of recombinant neuraminidase (NA) with suitable catalytic activity are needed. However, the functional activity of the full-length form of
Fatemeh Sadat Shariati, Fatemeh Fotouhi, Behrokh Farahmand, Zahra Barghi, Kayhan Azadmanesh   +4 more
doaj   +1 more source

Perspective of Use of Antiviral Peptides against Influenza Virus

Viruses, 2015
The threat of a worldwide influenza pandemic has greatly increased over the past decade with the emergence of highly virulent avian influenza strains. The increased frequency of drug-resistant influenza strains against currently available antiviral drugs
Sylvie Skalickova, Zbynek Heger, Ludmila Krejcova, Vladimir Pekarik, Karel Bastl, Jozef Janda, Frantisek Kostolansky, Eva Vareckova, Ondrej Zitka, Vojtech Adam, Rene Kizek   +10 more
doaj   +1 more source

Structural Investigations and Binding Mechanisms of Oseltamivir Drug Resistance Conferred by the E119V Mutation in Influenza H7N9 Virus

Molecules, 2022
The use of vaccinations and antiviral medications have gained popularity in the therapeutic management of avian influenza H7N9 virus lately. Antiviral medicines are more popular due to being readily available. The presence of the neuraminidase protein in
Samuel C. Ugbaja, Sphamandla E. Mtambo, Aganze G. Mushebenge, Patrick Appiah-Kubi, Bahijjahtu H. Abubakar, Mthobisi L. Ntuli, Hezekiel M. Kumalo   +6 more
doaj   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus

mBio, 2020
Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins but lost activity to the N1 with the substitution
Haihai Jiang, Weiyu Peng, Jianxun Qi, Yan Chai, Hao Song, Yuhai Bi, Pramila Rijal, Haiyuan Wang, Babayemi O. Oladejo, Jinhua Liu, Yi Shi, George F. Gao, Alain R. Townsend, Yan Wu   +13 more
doaj   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, EarlyView.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

In silico modeling of N294S mutation effect on the interaction of influenza virus N8 neuraminidase with zanamivir

Юг России: экология, развитие
The aim of the study is an in silico modeling of avian influenza A/H5N8 virus neuraminidase and zanamivir interaction using homology modeling and molecular docking. A/chicken/Tatarstan/88/2017 (wild type) and A/chicken/Tatarstan/112/2017 (N294S mutation)
E. A. Rukhlova, G. S. Onkhonova, M. N. Kosenko, I. M. Susloparov, I. A. Sobolev, A. B. Ryzhikov   +5 more
doaj   +1 more source