Results 61 to 70 of about 45,170 (239)

Antigenic Drift of the Influenza A(H1N1)pdm09 Virus Neuraminidase Results in Reduced Effectiveness of A/California/7/2009 (H1N1pdm09)-Specific Antibodies

mBio, 2019
The effectiveness of influenza vaccines against circulating A(H1N1)pdm09 viruses was modest for several seasons despite the absence of antigenic drift of hemagglutinin (HA), the primary vaccine component. Since antibodies against HA and neuraminidase (NA)
Jin Gao, Laura Couzens, David F. Burke, Hongquan Wan, Patrick Wilson, Matthew J. Memoli, Xiyan Xu, Ruth Harvey, Jens Wrammert, Rafi Ahmed, Jeffery K. Taubenberger, Derek J. Smith, Ron A. M. Fouchier, Maryna C. Eichelberger   +13 more
doaj   +1 more source

Neuraminidase production by Bacteroidaceae [PDF]

Journal of Medical Microbiology, 1981
The production of neuraminidase (EC 3.2.1.18) by 77 strains of Bacteroidaceae was investigated by techniques previously used to study neuraminidase production by clostridia. Conditions for culture and assay of Bacteroides fragilis neuraminidase were characterised.
A G, Fraser, R, Brown
openaire   +2 more sources

Therapeutic Efficacy of the Supersulfide Donor NAC‐S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses

Microbiology and Immunology, EarlyView.
ABSTRACT Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic, and anti‐inflammatory activities; however, their therapeutic potential after disease onset ...
Foysal Hossen, Takahisa Kouwaki, Yukio Fujiwara, Hiroyasu Tsutsuki, Tianli Zhang, Chunyu Guo, Azizur Rahman, Yoshihiro Komohara, Hiroyuki Oshiumi, Tomohiro Sawa   +9 more
wiley   +1 more source

Influenza neuraminidase mutations and resistance to neuraminidase inhibitors

Emerging Microbes & Infections
Mutations in influenza virus neuraminidase (NA) can lead to viral resistance to NA inhibitors (NAIs). To update global influenza NA mutations and resistance to NAIs, we investigated epidemic information from global regions for NAIs-resistant influenza strains and analyzed their NA mutations.
Jiapeng Xu, Qiting Luo, Yuanyuan Huang, Jieyu Li, Wei Ye, Ran Yan, Xinrui Zhou, Zhendan He, Ge Liu, Qinchang Zhu   +9 more
openaire   +3 more sources

Network medicine and systems pharmacology approaches to predicting adverse drug effects

British Journal of Pharmacology, EarlyView.
Identifying and understanding the relationships between drug intake and adverse effects that can occur due to inadvertent molecular interactions between drugs and targets is a difficult task, especially considering the numerous variables that can influence the onset of such events.
Alessio Funari, Giulia Fiscon, Paola Paci   +2 more
wiley   +1 more source

Adhesion of Immunoglobulins to Band3 Promotes Increased Erythrocyte Sedimentation Rate in Multiple Myeloma

Cell Proliferation, EarlyView.
Decreased sialic acid increases the adhesion of RBC membranes to immunoglobulins leading to an increased erythrocyte sedimentation rate (ESR). The increase in reactive oxygen species (ROS) damages the sialic acid glycosyl chains on the surface of RBC membrane proteins, causing the membrane proteins to be overexposed to the plasma environment due to the
Sicheng Bian, Jiangxia Cui, Xialin Zhang, Chongzhi Bai, Yanhong Tan, Zhuanghui Hao, Xingpeng Bu, Changxin Qu, Lili Sun, Leilei Lin, Qi Wang, Zhengrui Li, Xufeng Huang, Hengrui Liu, Ruo Wang, Yinghua Li, Hongwei Wang   +16 more
wiley   +1 more source

Novel advances in parainfluenza virus 3 neutralization through antibodies targeting hemagglutinin-neuraminidase [PDF]

, 2023
Rose Miller, Jarrod J. Mousa
openalex   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Characterisation of a phylogenetically distinct PL25 family ulvan lyase from a seaweed biomass enriched metagenome

The FEBS Journal, EarlyView.
Ulvan is a polysaccharide available from green seaweed with beneficial properties for various applications. The full potential of ulvan requires enzymatic degradation of the polymer, thus producing ulvan oligosaccharides. This study expands the armoury of characterised ulvan lyases.
Andrius Jasilionis, Pavithra Sivakumar, Justyna M. Dobruchowska, Sune Fjermedal, Hörður Guðmundsson, Bjorn Thor Adalsteinsson, Guðmundur Ó. Hreggviðsson, Anne S. Meyer, Eva Nordberg Karlsson   +8 more
wiley   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source