Results 81 to 90 of about 38,379 (201)

Monitoring and Characterization of Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus, Japan, 2009–2010

Emerging Infectious Diseases, 2011
To monitor and characterize oseltamivir-resistant (OR) pandemic (H1N1) 2009 virus with the H275Y mutation, we analyzed 4,307 clinical specimens from Japan by neuraminidase (NA) sequencing or inhibition assay; 61 OR pandemic (H1N1) 2009 viruses were ...
Makoto Ujike, Miho Ejima, Akane Anraku, Kozue Shimabukuro, Masatsugu Obuchi, Noriko Kishida, Xu Hong, Emi Takashita, Seiichiro Fujisaki, Kazuyo Yamashita, Hiroshi Horikawa, Yumiko Kato, Akio Oguchi, Nobuyuki Fujita, Masato Tashiro, Takato Odagiri   +15 more
doaj   +1 more source

Modeling Airborne Influenza in Three Dimensions

Engineering Reports, Volume 8, Issue 3, March 2026.
A novel 3D fluid dynamics model demonstrates how influenza outbreaks spread spatially via “epidemic flow.” Simulations reveal that direct contact is the dominant transmission route over aerosol spread, offering a new tool to inform targeted public health interventions and spatially‐aware risk assessment.
Daniel Ugochukwu Nnaji, Omeh Chinenye, Gabriel Chinedu Nnaji, Samuel Onuche John, Nnaemeka Stanley Aguegboh   +4 more
wiley   +1 more source

Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection

Advanced Genetics, Volume 7, Issue 1, March 2026.
This review synthesizes current knowledge on the molecular mechanisms underpinning H5N1's host adaptation, focusing on key mutations in viral proteins. Critical mutations are discussed in detail, highlighting their roles in altering receptor specificity, promoting antiviral resistance, and expanding viral tropism. The review underscores the urgent need
Wenxin Man, Lin Du, Ying Liu, Zehan Pang, Hongyan Zhu, Bixia Hong, Zhichao Xu, Huahao Fan   +7 more
wiley   +1 more source

Aptamer‐Based Approaches for Influenza Virus Detection: A Systematic Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Influenza remains a globally prevalent respiratory infection that is challenging to diagnose accurately. This systematic review focuses on aptamer‐based tools for influenza virus detection, aiming to overcome the limitations of traditional diagnostic methods.
Javad Charostad, Zohreh‐al‐sadat Ghoreshi, Nasir Arefinia, Faranak Salajegheh, Niloofar Farsiu, Mohammad Rezaei Zadeh Rukerd, Mohsen Nakhaie   +6 more
wiley   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry [PDF]

ChemMedChem
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Vogel I, Verganista M, Candeias N.
europepmc   +2 more sources

Mycochemical Diversity and Therapeutic Potential of Hymenochaetoid Fungi from Central Asia: Regional and Global Perspectives

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov, Milena Rašeta, Sylvie Rapior, Manzura Yarasheva, Oksana Mykchaylova, Rustamjon Allaberdiev, Şule İnci, Dilfuza Berdieva, Arshad Mehmood Abbasi, Shikhnazar Khodjaev, Dian‐Ming Hu, Weijun Yang, Abudujilili Abuduaini, Maria Letizia Taddei, Mengcen Wang, Islomjon Urinboev, Jiajia Chen   +16 more
wiley   +1 more source

Influenza a Neuraminidase-Based Bivalent mRNA Vaccine Induces Th1-Type Immune Response and Provides Protective Effects in Mice

Vaccines
Vaccines are one of the most effective means of preventing influenza A, typically containing the hemagglutinin (HA) of the influenza A virus. However, antigenic drift and shift of the influenza A virus can lead to instability in vaccine efficacy ...
Mingyang Li, Mengyuan Liu, Shaohui Song, Ruirui Zhao, Yun Xie, Jing Liu, Lilan Xu, Xuefeng Ma, Mingyu Song, Jian Zhou, Guoyang Liao   +10 more
doaj   +1 more source

Viral Pathogens and Pulmonary Fibrosis: EMT‐Driven Mechanisms and Insights From Traditional Chinese Medicine

Reviews in Medical Virology, Volume 36, Issue 2, March 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a serious progressive complication of the respiratory system, which is profoundly associated with persistent extracellular matrix (ECM) deposition, fibrosis, and disrupted tissue regeneration. Emerging evidence shows that epithelial–mesenchymal transition (EMT) acts as a key factor in the pathogenesis of ...
Ningzi Zang, Yingxu Wu, Pin Li, Yongming Liu, Shiwen Wang, Jiapeng Leng, Libin Zhan, Xiaodong Lyu, Lijian Pang, Jiaran Wang   +9 more
wiley   +1 more source

The Development of a Novel Broad-Spectrum Influenza Polypeptide Vaccine Based on Multi-Epitope Tandem Sequences

Vaccines
Background: Polypeptide vaccines have the potential to improve immune responses by targeting conserved and weakly immunogenic regions in antigens. This study aimed to identify and evaluate the efficacy of a novel influenza universal vaccine candidate ...
Song Zhao, Junhao Luo, Wenhui Guo, Li Li, Siyu Pu, Libo Dong, Wenfei Zhu, Rongbao Gao   +7 more
doaj   +1 more source

Therapeutic Efficacy of the Supersulfide Donor NAC‐S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses

Microbiology and Immunology, Volume 70, Issue 3, Page 148-159, March 2026.
ABSTRACT Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic, and anti‐inflammatory activities; however, their therapeutic potential after disease onset ...
Foysal Hossen, Takahisa Kouwaki, Yukio Fujiwara, Hiroyasu Tsutsuki, Tianli Zhang, Chunyu Guo, Azizur Rahman, Yoshihiro Komohara, Hiroyuki Oshiumi, Tomohiro Sawa   +9 more
wiley   +1 more source