Results 81 to 90 of about 43,769 (228)

Highly Pathogenic Avian Influenza A (H5N1) Infection in Bearded Vultures in Spain

Zoonoses and Public Health, EarlyView.
ABSTRACT We report mortality in bearded vultures (Gypaetus barbatus) associated with highly pathogenic avian influenza HPAI A H5N1 clade 2.3.4.4b, responsible for the current HPAI panzootic. Between April and May 2022, a total of five bearded vultures from Spain, four free‐ranging and one captive individual, were found dead in their nest or with acute ...
Remigio Martínez, Irene Agulló‐Ros, Moisés Gonzálvez, María J. Ruano, Bianca Zecchin, Irene Zorrilla, Rafael Guerra, Jorge Paniagua, David Cano‐Terriza, Ignacio García‐Bocanegra   +9 more
wiley   +1 more source

Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α

Advanced Science, Volume 12, Issue 25, July 3, 2025.
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, Mingrui Liu, Dongmei Zhang, Sixuan Lv, Junlian Gu   +13 more
wiley   +1 more source

Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus, Mexico

Emerging Infectious Diseases, 2011
During May 2009–April 2010, we analyzed 692 samples of pandemic (H1N1) 2009 virus from patients in Mexico. We detected the H275Y substitution of the neuraminidase gene in a specimen from an infant with pandemic (H1N1) 2009 who was treated with ...
José Ernesto Ramirez-Gonzalez, Elizabeth Gonzalez-Duran, Patricia Alcantara-Perez, Claudia Wong-Arambula, Hiram Olivera-Diaz, Iliana Cortez-Ortiz, Gisela Barrera-Badillo, Ha T. Nguyen, Larisa Gubareva, Irma Lopez-Martinez, Jose Alberto Díaz-Quiñonez, Miguel Angel Lezana-Fernández, Hugo Lopez Gatell-Ramírez, Jose Angel Cordova Villalobos, Mauricio Hernández-Avila, Celia M. Alpuche-Aranda   +15 more
doaj   +1 more source

Improved C5‐Amide Bioisosteres for Human Neuraminidase 1 Inhibitors Based on 2‐Deoxy‐2,3‐Didehydro‐N‐Acetyl Neuraminic Acid

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
This article describes the development of improved NEU1 inhibitors based on the 2‐deoxy‐2,3‐didehydro‐N‐acetyl neuraminic acid scaffold. A series of candidate inhibitors are designed containing bioisosteres of the C5‐amide group and evaluated for activity against NEU1‐4 enzymes.
Mostafa Radwan, Elisa G. Carvajal, Christopher W. Cairo   +2 more
wiley   +1 more source

The Tumour Glyco‐Code: Sialylation as a Mediator of Stromal Cell Immunosuppression in the Tumour Microenvironment

European Journal of Immunology, Volume 55, Issue 7, July 2025.
The Sialic acid/Siglec axis is emerging as an important target in the TME. We explore the role of sialylation within stromal‐rich, immunosuppressive TMEs, focusing on how specific sialic acid/Siglec interactions dictate innate and adaptive immune responses.
Aoise O'Neill, Norashikin Zakaria, Hannah Egan, Oliver Treacy, Aisling M. Hogan, Michael O'Dwyer, Sean O. Hynes, Aideen E. Ryan   +7 more
wiley   +1 more source

High Cell Density Perfusion Process of Quail Cells Producing Oncolytic rVSV‐NDV

Engineering in Life Sciences, Volume 25, Issue 7, July 2025.
ABSTRACT Oncolytic viruses as agents for the treatment of various types of cancer have demonstrated their potential in many clinical studies over the past decades. In particular, rVSV‐NDV (a recombinant vesicular stomatitis virus [VSV] construct with fusogenic Newcastle disease virus glycoproteins) shows promising preclinical results.
Lennart Jacobtorweihe, Sven Göbel, Markus Wolschek, Jennifer Altomonte, Udo Reichl, Yvonne Genzel   +5 more
wiley   +1 more source

Indirect Detection of Swine Influenza Activity in Porcine Blood Using Raman Spectroscopy and Machine Learning

Journal of Biophotonics, Volume 18, Issue 7, July 2025.
Blood serum from healthy swine, unvaccinated or vaccinated against porcine reproductive and respiratory syndrome, and vaccinated swine infected with H1N1 and H1N2 variants of swine influenza was analyzed using Raman spectroscopy. Partial least squares discriminant analysis and eXtreme gradient boosting discriminant analysis of the acquired spectra ...
Aidan Paul Holman, Axell Rodriguez, Ragd Elsaigh, Roa Elsaigh, Joseph Wilson, Matt H. Cohran, Dmitry Kurouski   +6 more
wiley   +1 more source

Self-amplifying mRNA bicistronic influenza vaccines raise cross-reactive immune responses in mice and prevent infection in ferrets

Molecular Therapy: Methods & Clinical Development, 2022
Vaccines are the primary intervention against influenza. Currently licensed inactivated vaccines focus immunity on viral hemagglutinin (HA). Self-amplifying mRNA (sa-mRNA) vaccines offer an opportunity to generate immunity to multiple viral proteins ...
Cheng Chang, Nedzad Music, Michael Cheung, Evan Rossignol, Sukhmani Bedi, Harsh Patel, Mohammad Safari, Changkeun Lee, Gillis R. Otten, Ethan C. Settembre, Giuseppe Palladino, Yingxia Wen   +11 more
doaj  

A chromogenic substrate for the investigation of neuraminidases [PDF]

, 1969
H. Tuppy, Peter Palese
openalex   +1 more source

From Bat to Worse: The Pivotal Role of Bats for Viral Zoonosis

Microbial Biotechnology, Volume 18, Issue 7, July 2025.
Thanks to a dampened inflammatory innate immune response, various Chiropteran (bat) species frequently carry ‐ without showing symptoms – diverse viruses that can cause severe diseases in humans. The reasons why bats are a pivotal virus reservoir for emerging viral diseases are discussed in this Lilliput contribution.
Harald Brüssow
wiley   +1 more source