Results 11 to 20 of about 134,617 (294)

Mechanisms of neurite repair [PDF]

Current Opinion in Neurobiology, 2020
Upon receiving injury signals, neurons can activate various pathways to reduce harm, initiate neuroprotection, and repair damaged neurite without cell death. Here, we review recent progresses in the study of neurite repair focusing on neuronal cell-autonomous mechanisms, including new findings on ion channels that serve as key regulators to initiate ...
Liu, Han-Hsuan, Jan, Yuh-Nung
openaire   +4 more sources

DDHD1, but Not DDHD2, Suppresses Neurite Outgrowth in SH-SY5Y and PC12 Cells by Regulating Protein Transport From Recycling Endosomes

Frontiers in Cell and Developmental Biology, 2020
DDHD1 and DDHD2 are both intracellular phospholipases A1 and hydrolyze phosphatidic acid in vitro. Given that phosphatidic acid participates in neurite outgrowth, we examined whether DDHD1 and DDHD2 regulate neurite outgrowth.
Yuki Maemoto, Tomohiro Maruyama, Kazuaki Nemoto, Takashi Baba, Takashi Baba, Manae Motohashi, Akihiro Ito, Mitsuo Tagaya, Katsuko Tani   +8 more
doaj   +1 more source

Optimization of Neurite Tracing and Further Characterization of Human Monocyte-Derived-Neuronal-like Cells

Brain Sciences, 2021
Deficits in neuronal structure are consistently associated with neurodevelopmental illnesses such as autism and schizophrenia. Nonetheless, the inability to access neurons from clinical patients has limited the study of early neurostructural changes ...
Alfredo Bellon, Tuna Hasoglu, Mallory Peterson, Katherine Gao, Michael Chen, Elisabeta Blandin, Alonso Cortez-Resendiz, Gary A. Clawson, Liyi Elliot Hong   +8 more
doaj   +1 more source

Ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons [PDF]

, 1990
A method for clamping cytosolic free Ca2+ ([Ca2+]i) in cultures of rat sympathetic neurons at or below resting levels for several days was devised to determine whether Ca2+ signals are required for neurite outgrowth from neurons that depend on Nerve ...
Murrell, R D, Suidan, H S, Tolkovsky, A M, Walker, A E   +3 more
core   +2 more sources

Construction of an image recognition algorithm based on neurite outgrowth of human motor neurons and its application in toxicological evaluation

陆军军医大学学报, 2023
Objective To develop an MATLAB algorithm for the automated measurement of motor neuron (MN) neurites and apply this algorithm to evaluate the organophosphate flame retardant tris (2-chloroethyl) phosphate (TCEP) on the growth of MN neurites.
DAI Zhiyuan, DAI Zhiyuan, ZHENG Yuanyuan, ZHANG Fangrong, NIE Haifeng, LI Xinyu   +5 more
doaj   +1 more source

Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. [PDF]

, 2017
Neurite initiation is the first step in neuronal development and occurs spontaneously in soft tissue environments. Although the mechanisms regulating the morphology of migratory cells on rigid substrates in cell culture are widely known, how soft ...
Chang, Ting-Ya, Chang, Ya-Chu, Chen, Chen, Cheng, Pei-Lin, Guo, Chin-Lin, Lee, Min, Lu, Chi-Huan, Lu, Shao-Tzu, Wang, Aijun, Wang, De-Yao   +9 more
core   +2 more sources

Liposomal delivery of hydrophobic RAMBAs provides good bioavailability and significant enhancement of retinoic acid signalling in neuroblastoma tumour cells [PDF]

, 2020
Retinoid treatment is employed during residual disease treatment in neuroblastoma, where the aim is to induce neural differentiation or death in tumour cells.
Bilip, Maja, Di Florio, Alessia, Eaton, Simon, Hart, Stephen L., Irving, Elsa, Maeshima, Ruhina, Mathiyalakan, Mayuran, Orford, Michael, Shah, Shreya, Simons, Claire, Stoker, Andrew W., Tagalakis, Aristides D.   +11 more
core   +4 more sources

Distinct molecular interactions mediate neuronal process outgrowth on non-neuronal cell surfaces and extracellular matrices. [PDF]

, 1986
We have compared neurite outgrowth on extracellular matrix (ECM) constituents to outgrowth on glial and muscle cell surfaces. Embryonic chick ciliary ganglion (CG) neurons regenerate neurites rapidly on surfaces coated with laminin (LN), fibronectin (FN),
Bixby, JL, Reichardt, LF, Tomaselli, KJ
core   +1 more source

BAF45D Downregulation in Spinal Cord Ependymal Cells Following Spinal Cord Injury in Adult Rats and Its Potential Role in the Development of Neuronal Lesions

Frontiers in Neuroscience, 2019
The endogenous spinal cord ependymal cells (SCECs), which form the central canal (CC), are critically involved in proliferation, differentiation and migration after spinal cord injury (SCI) and represents a repair cell source in treating SCI. Previously,
Zhenzhen Wang, Zhenzhen Wang, Zhenzhen Wang, Zhenzhen Wang, Jian Huang, Jian Huang, Jian Huang, Jian Huang, Chang Liu, Lihua Liu, Yuxian Shen, Cailiang Shen, Chao Liu, Chao Liu, Chao Liu   +14 more
doaj   +1 more source

The Tumor Suppressor HHEX Inhibits Axon Growth when Prematurely Expressed in Developing Central Nervous System Neurons [PDF]

, 2015
Neurons in the embryonic and peripheral nervoussystem respond to injury by activating transcriptional programs supportive of axon growth, ultimately resulting in functional recovery.
Blackmore, Murray G., Callif, Ben L., Coley, Denise M., Kramer, Audra A., Lerch, Jessica K., Simpson, Matthew T., Thiel, Laura K., Venkatesh, Ishwariya, Wang, Zimei, Winsor, Kristen N.   +9 more
core   +2 more sources