Results 51 to 60 of about 8,012 (216)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival

Neurobiology of Disease, 2009
We determined total Purkinje cell (PC) numbers in cerebella of wild-type (+/+) and heterozygous (rl/+) reeler mice of either sex during early postnatal development; in parallel, we quantified levels of neuroactive steroids in the cerebellum with mass ...
Filippo Biamonte, Giovanni Assenza, Ramona Marino, Marcello D'Amelio, Roger Panteri, Donatella Caruso, Samuele Scurati, Josue Garcia Yague, Luis Miguel Garcia-Segura, Roberta Cesa, Piergiorgio Strata, Roberto Cosimo Melcangi, Flavio Keller   +12 more
doaj   +1 more source

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes

Clinical &Experimental Allergy, EarlyView.
ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M. F. Wiegman, Aurelie Poli, Joanna Jacków‐Malinowska, Jack Cheeseman, Daniel I. R. Spencer, James McDonnell, James Spicer, Alexandra J. McCraw, Sophia N. Karagiannis   +13 more
wiley   +1 more source

Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides

Neurobiology of Stress
Steroid hormones and neurosteroids (collectively neuroactive steroids), alongside neuropeptides, are key modulators of the central nervous system. These signalling molecules integrate environmental cues into neurobiological responses by regulating gene ...
Katrina Z. Edmond, Natalie Matosin
doaj   +1 more source

Role of glial cells and neuroactive steroids in traumatic brain injury

Frontiers in Cellular Neuroscience, 2015
Traumatic Brain Injury TBI is a major public health problem causing high rates of morbidity and mortality. Currently, there are no effective pharmaceutical strategies to prevent its secondary injury cascades, which includes oxidative stress and metabolic
Luis Miguel Garcia-Segura, George E. Barreto   +1 more
doaj   +1 more source

Neuroactive steroids and metabolic axis

Frontiers in Neuroendocrinology, 2018
Neuroactive steroids (i.e., steroids synthesised both in peripheral glands and in nervous system) are important physiological regulators of the nervous functions. In particular, they are involved in the control of many physiological aspects of reproduction, stress response, and metabolism, as well as in several pathologies including depression, obesity,
Melcangi, R. C., Panzica, G. C.
openaire   +3 more sources

Tandem MADS‐Box Genes FUL2 and MADS1 Form a Regulatory Module to Repress Serotonin Biosynthesis via Direct ASMT5 Activation in Tomato Fruit

Plant Biotechnology Journal, EarlyView.
ABSTRACT The regulation of serotonin metabolism during fruit development and ripening remains poorly understood, despite its potential roles in plant defence and human nutrition. Here, we demonstrated that the MADS‐box transcription factor FUL2 acts as a key repressor of serotonin accumulation in tomato by forming a functional module with MADS1. CRISPR‐
Yaping Xu, Huimin Jia, Dengguo Tang, Lijun Zhang, Xinqin Liu, Junjie Rong, Yunai Lv, Zhaobo Lang, Qingfeng Niu   +8 more
wiley   +1 more source

Comparative electrophysiological study of neuroactive steroid-induced hypnosis in mice: sex and drug-specific differences

Experimental Biology and Medicine
Since the discovery of their anesthetic effects, some neuroactive steroids have been used as general anesthetics. However, their effects on thalamocortical oscillations and potential sex differences that are associated with their hypnotic/sedative ...
Abigail Martin, Ian Coulter, Reginald Cox, Douglas F. Covey, Douglas F. Covey, Slobodan M. Todorovic, Slobodan M. Todorovic, Tamara Timic Stamenic   +7 more
doaj   +1 more source

Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder

Biomolecules, 2022
Chronic cocaine use leads to adaptations in stress biology and in neuroactive steroid system. These adaptations are associated with high cocaine craving and increased relapse risk.
Verica Milivojevic, Lily Charron, Nia Fogelman, Gretchen Hermes, Rajita Sinha   +4 more
doaj   +1 more source

Lack of neurosteroid selectivity at δ vs. γ2-containing GABAA receptors in dentate granule neurons [PDF]

, 2020
GAB
Lu, Xinguo, Mennerick, Steven, Zorumski, Charles F   +2 more
core   +1 more source