Results 61 to 70 of about 345,011 (339)

How to target apoptosis signaling pathways for the treatment of pediatric cancers [PDF]

, 2013
Apoptosis represents one of the most important forms of cell death in higher organisms and is typically dysregulated in human cancers, including pediatric tumors.
Fulda, Simone
core   +2 more sources

Exploring the Role of Fibroblasts in Promoting Neuroblastoma Cell Migration and Invasion

Journal of Nanotheranostics
Neuroblastoma, the most common pediatric extracranial solid tumor, arises from the malignant transformation of neural crest progenitors in the peripheral nervous system.
Diana Corallo, Cristina Nardelli, Marcella Pantile, Sara Menegazzo, Alessandra Biffi, Sanja Aveic   +5 more
doaj   +1 more source

Applications and prospects of targeted therapy for neuroblastoma

World Journal of Pediatric Surgery, 2020
Background Neuroblastoma is an extremely malignant tumor in children. For advanced or recurrent cases, existing treatment modalities are limited and efficacy remains disappointing.
Jing Wang, Kai Li, Wei Yao
doaj   +1 more source

Topotecan-vincristine-doxorubicin in stage 4 high risk neuroblastoma patients failing to achieve a complete metastatic response to rapid COJEC : a SIOPEN study [PDF]

, 2018
Purpose : Metastatic response to induction therapy for high-risk neuroblastoma is a prognostic factor. In the International Society of Paediatric Oncology Europe Neuroblastoma (SIOPEN) HR-NBL-1 protocol, only patients with metastatic complete response ...
Amoroso, L, Brock, P, Castel, V, Erminio, G, Garaventa, A, Grp, Siopen, Haupt, R, Ladenstein, R, Laureys, G, Luksch, R, Makin, G, Pasquet, M, Pearson, A. D. J, Thomas, C, Valteau-Couanet, D   +14 more
core   +2 more sources

Targeting of the MYCN protein with small molecule c-MYC inhibitors [PDF]

, 2014
This study was funded by grants from the Swedish Research Council and the Swedish Cancer Society. IM and HZ were recipients of graduate student grants from KI (KID), MAH was recipient of a Senior Investigator Award from the Swedish Cancer Society, and ...
Frenzel, Anna, Henriksson, Marie Arsenian, Larsson, Karin, Muller, Inga, Oliynyk, Ganna, Prochownik, Edward V., Westwood, Nicholas J., Zirath, Hanna   +7 more
core   +3 more sources

Identification of lncRNAs Associated With Neuroblastoma in Cross-Sectional Databases: Potential Biomarkers

Frontiers in Molecular Neuroscience, 2019
Long non-coding RNAs (lncRNAs) have emerged as an important regulatory control in biological systems. Though the field of lncRNA has been progressing rapidly, a complete understanding of the role of lncRNAs in neuroblastoma pathogenesis is still lacking.
Bharat Prajapati, Mena Fatma, Mahar Fatima, Md Tipu Khan, Subrata Sinha, Subrata Sinha, Prahlad K. Seth   +6 more
doaj   +1 more source

Selective inhibition of the p53–MDM2 interaction by nutlin drugs: a new therapeutic perspective for neuroblastoma [PDF]

, 2013
Neuroblastoma is one of the most common and most deadly childhood tumors. There is an unmet need to develop new therapeutic modalities for this malignancy that preferentially should be guided by our increasing knowledge of the biology of neuroblastoma ...
De Paepe, Anne, Rihani, Ali, Speleman, Franki, Van Goethem, Alan, Van Maerken, Tom, Vandesompele, Jo   +5 more
core   +1 more source

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li, Raquel Revuelta Iniesta, Alan R. Barker, Dimitris Vlachopoulos, Tomáš Sláma, Christina Schindera, Fabiën N. Belle   +6 more
wiley   +1 more source

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma

Cancer Research, 2021
These findings demonstrate a novel role for DLST in neuroblastoma aggression and identify the OXPHOS inhibitor IACS-010759 as a potential therapeutic strategy for this deadly disease.
Nicole M. Anderson, Xiaodan Qin, Jennifer M. Finan, Andrew Lam, Jacob Athoe, R. Missiaen, Nicolas Skuli, Annie Kennedy, A. S. Saini, Ting Tao, Shizhen Zhu, Itzhak Nissim, A. Look, Guoliang Qing, M. Simon, H. Feng   +15 more
semanticscholar   +1 more source