Results 1 to 10 of about 319,447 (239)
Mitochondrial Neurodegeneration [PDF]
Cells, 2022 Mitochondria are cytoplasmic organelles, which generate energy as heat and ATP, the universal energy currency of the cell. This process is carried out by coupling electron stripping through oxidation of nutrient substrates with the formation of a proton-based electrochemical gradient across the inner mitochondrial membrane.
Zeviani, Massimo, Viscomi, Carlo
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Deubiquitinases in Neurodegeneration [PDF]
Cells, 2022 Ubiquitination refers to the conjugation of the ubiquitin protein (a small protein highly conserved among eukaryotes) to itself or to other proteins through differential use of ubiquitin’s seven internal linkage sites or the amino-terminal amino group. By creating different chain lengths, an enormous proteomic diversity may be formed.
Abudu I. Bello +7 more
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Nanomaterials and neurodegeneration [PDF]
Environmental and Molecular Mutagenesis, 2015 The increasing application of nanotechnology in various industrial, environmental, and human settings raises questions surrounding the potential adverse effects induced by nanosized materials to human health, including the possible neurotoxic and neuroinflammatory properties of those substances and their capability to induce neurodegeneration.
MIGLIORE, LUCIA +3 more
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Autophagy and neurodegeneration [PDF]
Free Radical Biology and Medicine, 2012 Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a powerful process for removing such proteins. In this Review, we consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology.
Thomas Ricketts +3 more
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Chronochemistry in neurodegeneration [PDF]
Frontiers in Molecular Neuroscience, 2014 The problem of distinguishing causes from effects is not a trivial one, as illustrated by the science fiction writer Isaac Asimov in a novel dedicated to an imaginary compound with surprising "chronochemistry" properties. The problem is particularly important when trying to establish the etiology of diseases.
Pastore, Annalisa, ADINOLFI, Salvatore
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Immunotherapy for neurodegeneration? [PDF]
Science, 2019 The role of innate and adaptive immunity in neurodegeneration remains ...
Liu, Yingjun, Aguzzi, Adriano
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Ecstasy and neurodegeneration [PDF]
BMJ, 1996 Publicity in the popular press and medical journals1 on the dangers of using ecstasy (3,4-methylenedioxymethamphetamine) has concentrated almost exclusively on the problems of acute toxicity. While the unnecessary death of any young person is rightly deplored, it is strange that so little attention is being paid to the long term effects of this ...
A R Green, G M Goodwin
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Viruses and neurodegeneration [PDF]
Virology Journal, 2013 AbstractNeurodegenerative diseases (NDs) are chronic degenerative diseases of the central nervous system (CNS), which affect 37 million people worldwide. As the lifespan increases, the NDs are the fourth leading cause of death in the developed countries and becoming increasingly prevalent in developing countries.
Nitin K. Saksena +2 more
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Cytoskeleton, 2023 AbstractFirst identified in 1975, tau was implicated in Alzheimer's disease 10 years later. Filamentous tangle inclusions were known to be made of hyperphosphorylated tau by 1991, with similar inclusions gaining recognition for being associated with other neurodegenerative diseases. In 1998, mutations in MAPT, the gene that encodes tau, were identified
Goedert, Michel +3 more
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C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins [PDF]
, 2014 An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins ...
Cabecinha, M +19 more
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