Results 271 to 280 of about 271,126 (314)
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Autophagy and neurodegeneration
Current Neurology and Neuroscience Reports, 2007All cellular components are subjected to continuous surveillance by intracellular quality control systems. The major players involved in this quality control are molecular chaperones, which detect the abnormal components, and proteases, which eliminate them from the cell.
Annamaria, Ventruti, Ana Maria, Cuervo
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Neurotrophins and neurodegeneration
Neuropathology and Applied Neurobiology, 2003There is growing evidence that reduced neurotrophic support is a significant factor in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). In this review we discuss the structure and functions of neurotrophins such as nerve growth factor, and the role of ...
Dawbarn, D, Allen, SJ
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Neurodegeneration and peroxidases
Neurobiology of Aging, 2009Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases that affect different parts of the central nervous system. However, a review of the literature indicates that certain biochemical reactions involved in neurodegeneration in these three diseases are quite similar and could be partly ...
Johannes, Everse, Penelope W, Coates
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Neurodegeneration and the Cerebellum
Neurodegenerative Diseases, 2017<b><i>Background:</i></b> The cerebellum modulates diverse neuronal networks, regulating motor, cognitive, behavioral, and limbic circuits. Structural and functional changes to the cerebellum that occur with neurodegenerative conditions have not been systematically reviewed.
Samson, Margot, Claassen, Daniel O.
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Autoimmunity in neurodegeneration
Science, 2021A signaling axis in adaptive immunity is a potential target in Lewy body ...
Maria, Krot, Asya, Rolls
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Mitochondria in neurodegeneration
Current Opinion in Physiology, 2022The brain is one of the most energetically demanding tissues in the human body, and mitochondrial pathology is strongly implicated in chronic neurodegenerative diseases. In contrast to acute brain injuries in which bioenergetics and cell death play dominant roles, studies modeling familial neurodegeneration implicate a more complex and nuanced ...
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Macrophages and neurodegeneration
Brain Research Reviews, 2005Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Demyelination is a classical feature of MS lesions, and neurological deficits are often ascribed to the reduced signal conduction by demyelinated axons. However, recent studies emphasize that axonal loss is an important factor in MS pathogenesis
Jerome J A, Hendriks +3 more
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Connectomics of neurodegeneration
Nature Neuroscience, 2019Misfolded protein aggregates are a classical hallmark of many neurodegenerative diseases. By combining a mouse model of misfolded protein injection and a brain network model of misfolded protein diffusion, a study now finds a strong link between the stereotypical spreading patterns of neurodegeneration, protein expression and anatomical connectivity.
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Neurodegeneration and plasticity
International Journal of Developmental Neuroscience, 2004AbstractNeurofibrillary degeneration, associated with the formation of paired helical filaments (PHF), is one of the critical neuropathological hallmarks of Alzheimer's disease (AD). Although the microtubule‐associated protein tau in a hyperphosphorylated form has been established as primary PHF constituent, the process of tau phosphorylation and its ...
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Osteoporosis in neurodegeneration
Journal of Trace Elements in Medicine and Biology, 2014Osteoporosis affects bone microarchitecture and reduces bone mass. There are more than 200 million people with osteoporosis worldwide, and the prevalence is slowly increasing. The highest prevalences are found in Scandinavia and USA, also slowly increasing.
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