Results 281 to 290 of about 271,126 (314)
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Ageing Research Reviews, 2015
The concept of neuroinflammation has come a full circle; from being initially regarded as a controversial viewpoint to its present day acceptance as an integral component of neurodegenerative processes. A closer look at the etiopathogenesis of many neurodegenerative conditions will reveal a patho-symbiotic relationship between neuroinflammation and ...
John, Thundyil, Kah-Leong, Lim
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The concept of neuroinflammation has come a full circle; from being initially regarded as a controversial viewpoint to its present day acceptance as an integral component of neurodegenerative processes. A closer look at the etiopathogenesis of many neurodegenerative conditions will reveal a patho-symbiotic relationship between neuroinflammation and ...
John, Thundyil, Kah-Leong, Lim
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Acta Neuropathologica, 2009
Mutations in leucine-rich repeat kinase 2 gene (PARK8/LRRK2) encoding the protein Lrrk2 are causative of inherited and sporadic Parkinson's disease (PD) with phenotypic manifestations of frontotemporal lobar degeneration, corticobasal degeneration and associated motor neuron disease in some patients, and with variable penetrance.
Gabriel, Santpere, Isidre, Ferrer
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Mutations in leucine-rich repeat kinase 2 gene (PARK8/LRRK2) encoding the protein Lrrk2 are causative of inherited and sporadic Parkinson's disease (PD) with phenotypic manifestations of frontotemporal lobar degeneration, corticobasal degeneration and associated motor neuron disease in some patients, and with variable penetrance.
Gabriel, Santpere, Isidre, Ferrer
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The Proteomics of Neurodegeneration
American Journal of PharmacoGenomics, 2005The continuing improvement and refinement of proteomic and bioinformatic tools has made it possible to obtain increasing amounts of structural and functional information about proteins on a global scale. The emerging field of neuroproteomics promises to provide powerful strategies for further characterizing neuronal dysfunction and cell loss associated
Mark D, Johnson +7 more
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Neurodegeneration in schizophrenia
Expert Review of Neurotherapeutics, 2010The neurodegenerative aspect of schizophrenia presupposes gene-environmental interactions involving chromosomal abnormalities and obstetric/perinatal complications that culminate in predispositions that impart a particular vulnerability for drastic and unpredictable precipitating factors, such as stress or chemical agents.
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microRNAs in neurodegeneration
Current Opinion in Neurobiology, 2008microRNAs (miRNAs) act as post-transcriptional regulators of gene expression in diverse cellular and developmental processes. Many miRNAs are expressed specifically in the central nervous system, where they have roles in differentiation, neuronal survival, and potentially also in plasticity and learning.
Natascha, Bushati, Stephen M, Cohen
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Neurodegeneration and Inflammation
Nutrition in Clinical Practice, 2008Recent studies have demonstrated a strong link between neurodegeneration and chronic inflammation. The central nervous system (CNS) has very limited regenerative capacity. Neural cell death occurs by apoptosis and necrosis. Necrosis in the CNS usually follows ischemic or traumatic brain injury.
Mark H, DeLegge, Addy, Smoke
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Metallochemistry of Neurodegeneration
2006Bioinorganic chemistry has a cross disciplinary approach, applying the principles of chemistry to biological systems. Metallochemistry of Neurodegeneration: Biological, Chemical and Genetic Aspects discusses the rapidly developing area of metals in the nervous system and their role in neurodegenerative disease, such as Alzheimer's, Parkinson's and ...
D. R. BROWN +2 more
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Mitochondria, NO and neurodegeneration
Biochemical Society Symposia, 1999A role for mitochondrial dysfunction in neurodegenerative disease is gaining increasing support. Mitochondrial dysfunction may be linked to neurodegenerative diseases through a variety of different pathways, including free-radical generation, impaired calcium buffering and the mitochondrial permeability transition.
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Neuroglia in neurodegeneration
Brain Research Reviews, 2010Neuroglial cells are fundamental for control of brain homeostasis and they represent the intrinsic brain defence system. All forms in neuropathology therefore inevitably involve glia. The neurodegenerative diseases disrupt connectivity within brain circuits affecting neuronal-neuronal, neuronal-glial and glial-glial contacts.
Heneka, Michael T. +2 more
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PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson’s disease
Cell, 2022Hyejin Park, Tae-In Kam, Hanjing Peng
exaly