Results 91 to 100 of about 464,323 (316)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source
Altered Expression of ZnT10 in Alzheimer's Disease Brain [PDF]
, 2013 There is an increasing body of evidence suggesting that metal homeostasis is dysregulated in the pathology of Alzheimer's disease (AD). Although expression levels of several transporters belonging the SLC30 family, which comprises predominantly zinc ...
Ruth A. Valentine (208371) +19 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source
, 2023 In neurodegenerative cerebellar ataxias, not only ataxia but also extra-cerebellar signs have a significant impact on patients’ health related to quality of life (HRQoL).
Gorica Marić +8 more
core +1 more source
Metallothionein and neurodegenerative diseases
Neural Regeneration ResearchNeurodegenerative diseases, which mainly include Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Wilson’s disease, and Huntington’s disease, are a group of disorders characterized by loss of neurons in the brain and spinal cord. However, the underlying pathogenetic mechanisms of these disorders remain unclear.
Yufeng Cheng +3 more
openaire +2 more sources
Neurodegenerative diseases: challenges [PDF]
Drug Delivery and Translational Research, 2011 Diseases of the aging brain—including Alzheimer’s, Parkinson’s, and Huntington’s—affect the lives of millions and pose a growing threat to public health. These diseases occur as a result of neurodegenerative processes involving the progressive loss of structure or function of neurons, including death of neurons.
openaire +2 more sources
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
The connection between Gaucher disease and neurodegenerative diseases
, 2021 A literature review, investigating the commonalities between the rare, but treatable lysosomal storage disorder known as Gaucher disease (Type 1), and common, but terminal age-related neurodegenerative diseases; Alzheimer's disease and Parkinson's ...
Sadie, Bonita Lee-Ann
core
Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease [PDF]
, 2007 So far, only the detection of 14-3-3 proteins in cerebrospinal fluid (CSF) has been accepted as diagnostic criterion for Creutzfeldt-Jakob disease (CJD). However, this assay cannot be used for screening because of the high rate of false-positive results,
Steinacker, Petra +8 more
core +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source