Results 101 to 110 of about 5,310,608 (313)

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Memory in Neurodegenerative Disease [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1999
Memory in Neurodegenerative Disease . Edited by alexander i troster. (Pp 413, £60.00 (US $95.00). Published by Cambridge University Press, Cambridge 1998. ISBN 0-521-57192-8. No one can doubt the increasing importance, to affected families and the healthcare system, of Alzheimer’s disease, Parkinson’s disease, and the other degenerative conditions of ...
openaire   +2 more sources

Altered Expression of ZnT10 in Alzheimer's Disease Brain [PDF]

, 2013
There is an increasing body of evidence suggesting that metal homeostasis is dysregulated in the pathology of Alzheimer's disease (AD). Although expression levels of several transporters belonging the SLC30 family, which comprises predominantly zinc ...
Ruth A. Valentine (208371), Paul A Adlard, Ruth A. Valentine, Helen J. Bosomworth (417547), Ford, D, Bosomworth, Helen, Adlard, Paul, Dianne Ford, Valentine, Ruth, Paul A. Adlard, Paul A. Adlard (31148), Dianne Ford (174115), Bosomworth, HJ, Helen J Bosomworth, Ruth A Valentine, Skoulakis, Efthimios, Helen J. Bosomworth, Adlard, PA, Valentine, RA, Ford, Dianne   +19 more
core   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease [PDF]

, 2007
So far, only the detection of 14-3-3 proteins in cerebrospinal fluid (CSF) has been accepted as diagnostic criterion for Creutzfeldt-Jakob disease (CJD). However, this assay cannot be used for screening because of the high rate of false-positive results,
Steinacker, Petra, Brechlin, Peter, Cepek, Lukas, Klingebiel, Enrico, Bibl, Mirko, Kretzschmar, Hans A., Mollenhauer, Brit, Otto, Markus, Wiltfang, Jens   +8 more
core   +1 more source

Measuring Oxidative Stress in Caenorhabditis elegans: Paraquat and Juglone Sensitivity Assays

Bio-Protocol, 2017
Oxidative stress has been proposed to be one of the main causes of aging and has been implicated in the pathogenesis of many diseases. Sensitivity to oxidative stress can be measured by quantifying survival following exposure to a reactive oxygen species
Megan Senchuk, Dylan Dues , Jeremy Van Raamsdonk   +2 more
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

The connection between Gaucher disease and neurodegenerative diseases

, 2021
A literature review, investigating the commonalities between the rare, but treatable lysosomal storage disorder known as Gaucher disease (Type 1), and common, but terminal age-related neurodegenerative diseases; Alzheimer's disease and Parkinson's ...
Sadie, Bonita Lee-Ann
core  

Recording γ-secretase activity in living mouse brains

eLife
γ-Secretase plays a pivotal role in the central nervous system. Our recent development of genetically encoded Förster resonance energy transfer (FRET)-based biosensors has enabled the spatiotemporal recording of γ-secretase activity on a cell-by-cell ...
Steven S Hou, Yuya Ikegawa, Yeseo Kwon, Natalia Wieckiewicz, Mei CQ Houser, Brianna Lundin, Brian J Bacskai, Oksana Berezovska, Masato Maesako   +8 more
doaj   +1 more source

Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease

Neurobiology of Disease, 2009
Senile plaque-associated changes in neuronal connectivity such as altered neurite trajectory, dystrophic swellings, and synapse and dendritic spine loss are thought to contribute to cognitive dysfunction in Alzheimer's disease and mouse models ...
Tara L. Spires-Jones, Matthew L. Mielke, Anete Rozkalne, Melanie Meyer-Luehmann, Alix de Calignon, Brian J. Bacskai, Dale Schenk, Bradley T. Hyman   +7 more
doaj   +1 more source