Results 121 to 130 of about 5,310,608 (313)

Integrating Mitochondrial Biology into Innovative Cell Therapies for Neurodegenerative Diseases. [PDF]

The role of mitochondria in neurodegenerative diseases is crucial, and recent developments have highlighted its significance in cell therapy. Mitochondrial dysfunction has been implicated in various neurodegenerative disorders, including Alzheimers ...
Giulivi, Cecilia, James M. Angelastro, Cecilia Giulivi, Angelastro, James, Ore, Adaleiz, Adaleiz Ore   +5 more
core   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Glia in Neurodegenerative Disease

Cold Spring Harbor Perspectives in Biology
It is becoming increasingly clear that the dominant, century-old neurocentric view of neurodegeneration is insufficient to explain why certain neurons degenerate, in particular with aging. Genetic studies in patient populations as well as mechanistic and functional studies in animal models altogether implicate nonneuronal cells, especially glia, to ...
Gerard Crowley, David Attwell, Hemali Phatnani, Harald Sontheimer, Soyon Hong   +4 more
openaire   +3 more sources

Longitudinal Modelling for Single Nucleotide Polymorphism Associations with Alzheimer’s Disease

, 2023
International audienceRobust associations between genetic traits and neurodegenerative pathologies have been established thanks to the advent of GWAS. Meta-analysis incorporating tens of thousands of subjects allowed to discover hundreds of genetic loci ...
Fournier, Nemo, Durrleman, Stanley
core   +2 more sources

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Peptide fingerprinting of Alzheimer's disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkers [PDF]

, 2011
<p><b>Background:</b> Today, dementias are diagnosed late in the course of disease. Future treatments have to start earlier in the disease process to avoid disability requiring new diagnostic tools.
Jahn Holger, Thomas J Raedler, William Mullen, Kellmann Markus, Arlt Sönke, Eichenlaub, M., Zürbig Petra, Kellmann, M., Jahn, H., Wittke Stefan, Mischak Harald, Stefan Wittke, Mischak, H., Petra Zürbig, Thomas J. Raedler, Z, P., Mullen, W., Wittke, S., Holger Jahn, Mullen William, Wiedemann Klaus, Harald Mischak, Markus Kellmann, Klaus Wiedemann, Martin Eichenlaub, Raedler Thomas J., Sönke Arlt, Eichenlaub Martin   +27 more
core   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Influence of sleep disruption on protein accumulation in neurodegenerative diseases

, 2022
Abnormal accumulation of disease proteins in the central nervous system is a neuropathological feature in neurodegenerative disorders. Recently, a growing body of evidence has supported a role of disruption of the sleep-wake cycle in disease development,
Li, Jiada, Wang, Xiying, Wang, Rui
core  

Vascular Disease, Non‐Steroidal Anti‐Inflammatory Drugs and Risk of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives A history of vascular disease has been shown to be associated with an increased risk of Parkinson's disease, but this may be due to reverse causation. In addition, non‐steroidal anti‐inflammatory drugs are thought to reduce Parkinson's disease risk, but evidence is inconsistent and confounding by prior vascular disease is possible ...
Clare Wotton, Carol Hermon, Sarah Floud, Gillian Reeves, Isobel Barnes   +4 more
wiley   +1 more source

Molecular targets in protein misfolding and neurodegenerative disease /

Aimed at "drug discoverers"--I.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative ...
Seneci, Pierfausto,author.
core