Results 111 to 120 of about 470,350 (340)

Gut Microbiota and the Neuroendocrine System

Neurotherapeutics, 2018
The microbial ecosystem that inhabits the gastrointestinal tract of all mammals—the gut microbiota—has been in a symbiotic relationship with its hosts over many millennia.
A. Farzi, Esther E. Fröhlich, P. Holzer
semanticscholar   +1 more source

Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance NEPC is a highly aggressive subtype of prostate cancer that is increasing in incidence, likely due to use of new secondary androgen deprivation therapies.
E. Hsu, M. Rice, Abel Bermudez, F. Marques, Merve Aslan, Shiqin Liu, A. Ghoochani, C. Zhang, Yun-Sheng Chen, A. Zlitni, Sahil Kumar, R. Nolley, F. Habte, Michelle Shen, Kashyap Koul, D. Peehl, A. Zoubeidi, S. Gambhir, C. Kunder, Sharon J. Pitteri, J. Brooks, Tanya Stoyanova   +21 more
semanticscholar   +1 more source

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source

Pancreatic neuroendocrine tumours

European Journal of Surgical Oncology (EJSO), 2008
Pancreatic neuroendocrine tumours (PET) are rare neoplasms of the pancreas accounting for less than 5% of all primary pancreatic malignancies. Included in this group are insulinomas, gastrinomas, glucagonoma and somatostatinomas. Collectively these neoplasms are classified as functional PETs.
H L, O'Grady, K C, Conlon
openaire   +5 more sources

Higher serum myostatin levels are associated with lower insulin sensitivity in adults with overweight/obesity

Physiological Reports
Myostatin inhibition improves insulin sensitivity in preclinical and clinical models; however, studies investigating the relationship between serum myostatin levels and insulin sensitivity are discrepant.
Laura E. Dichtel, Allison Kimball, Bryan Bollinger, Geetanjali Scarff, Anu V. Gerweck, Miriam A. Bredella, Melanie S. Haines   +6 more
doaj   +1 more source

Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors [PDF]

, 2019
Work-related stress is a growing health problem in modern society. The stress response is characterized by numerous neurochemicals, neuroendocrine and immune modifications that involve various neurological systems and circuits, and regulation of the gene
Emanuele Cannizzaro, Fulvio Plescia, Luigi Cirrincione, Tiziana Ramaci   +3 more
core   +1 more source

MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer

Nature Communications, 2020
Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC, but its specific role is unknown.
Y. Yasumizu, H. Rajabi, Caining Jin, Tsuyoshi Hata, S. Pitroda, M. Long, Masayuki Hagiwara, Wei Li, Q. Hu, Song Liu, N. Yamashita, A. Fushimi, Ling Kui, M. Samur, Masaaki Yamamoto, Yan Zhang, Ning Zhang, D. Hong, T. Maeda, T. Kosaka, Kwok-kin Wong, M. Oya, D. Kufe   +22 more
semanticscholar   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Auditory pallial regulation of the social behavior network

Communications Biology
Sensory cues such as vocalizations contain important social information. Processing social features of vocalizations (e.g., vocalizer identity, emotional state) necessitates unpacking the complex sound streams in song or speech; this depends on circuits ...
Jeremy A. Spool, Anna P. Lally, Luke Remage-Healey   +2 more
doaj   +1 more source