Results 61 to 70 of about 470,350 (340)

Metastasizing esthesioneuroblastoma in a dog [PDF]

, 2014
A 7-year-old Afghan hound presented with a history of disorientation, loss of vision, and seizures. Magnetic resonance imaging helped identify a mass at the level of the main olfactory bulb that compressed and displaced adjacent tissues in the cribriform
Herden, Christiane, Klingler, Melanie, Schmidt, Martin J., Siudak, Krystyna   +3 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Tumor-derived apolipoprotein E confers resistance to temozolomide in pancreatic neuroendocrine tumors

Cell Death and Disease
Temozolomide (TMZ) is a first-class clinical drug for patients with pancreatic neuroendocrine tumors (pNETs). However, the therapeutic effects of TMZ are limited because of the chemoresistance of pNET cells, which has not been fully elucidated.
Xin Lou, Yihua Shi, Yi Qin, Wuhu Zhang, Zeng Ye, Fei Wang, Yan Wang, Tian Ding, Desheng Jing, Guixiong Fan, Yue Zhang, Xuemin Chen, Xiaowu Xu, Xianjun Yu, Shunrong Ji, Junfeng Xu   +15 more
doaj   +1 more source

What is New in 2019 World Health Organization (WHO) Classification of Tumors of the Digestive System: Review of Selected Updates on Neuroendocrine Neoplasms, Appendiceal Tumors, and Molecular Testing.

Archives of Pathology & Laboratory Medicine, 2020
CONTEXT.— The 5th edition of the World Health Organization classification of digestive system tumors discusses several advancements and developments in understanding the etiology, pathogenesis, and diagnosis of several digestive tract tumors. OBJECTIVE.
N. Assarzadegan, E. Montgomery
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms

Journal of Translational Medicine
Background Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare. Hypoxia and lipid metabolism-related gene acetyl-CoA synthetase 2 (ACSS2) is involved in tumor progression, but its role in pNENs is not revealed.
Danyang Gu, Mujie Ye, Guoqin Zhu, Jianan Bai, Jinhao Chen, Lijun Yan, Ping Yu, Feiyu Lu, Chunhua Hu, Yuan Zhong, Pengfei Liu, Qibin He, Qiyun Tang   +12 more
doaj   +1 more source

Obesity and Hypogonadism—A Narrative Review Highlighting the Need for High-Quality Data in Adolescents

Children, 2019
The prevalence of obesity continues to rise in adult and pediatric populations throughout the world. Obesity has a direct impact on all organ systems, including the reproductive system.
Tasnim Mushannen, Priscilla Cortez, Fatima Cody Stanford, Vibha Singhal   +3 more
doaj   +1 more source

Diagnostic features and management options for duodenal neuroendocrine neoplasms: a retrospective, multi-centre study

Scientific Reports, 2022
Duodenal neuroendocrine neoplasms (dNENs) are rare neoplasms but their incidence is on the rise. They are classified into 5 sub-types but there remains much heterogeneity in behaviour in particular of non-functioning dNENs.
Dalvinder Mandair, Lukasz Kamieniarz, Michail Pizanias, Martin O. Weickert, Akshay Narayan, Luke Furtado O’Mahony, Martyn Caplin, John Ramage, Andreas Prachalias, Rajaventhan Srirajaskanthan, Christos Toumpanakis   +10 more
doaj   +1 more source

The Role of RFamide-Related Peptide-3 in Age-Related Reproductive Decline in Female Rats. [PDF]

, 2016
Reproductive senescence, the point in time when females cease to show estrous cyclicity, is associated with endocrine changes in the hypothalamus, pituitary, and gonads. However, the mechanisms triggering this transition are not well understood.
Bentley, George E, Geraghty, Anna C, Kaufer, Daniela, Kriegsfeld, Lance J, Muroy, Sandra E   +4 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source