Results 21 to 30 of about 129,345 (287)
Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors
Frontiers in Neuroscience, 2019 In recent years, the need to derive sources of specialized cell types to be employed for cell replacement therapies and modeling studies has triggered a fast acceleration of novel cell reprogramming methods.
Gaia Colasante +5 more
doaj +1 more source
Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition
Nature Communications, 2023 Within the chromatin, distal elements interact with promoters to regulate specific transcriptional programs. Histone acetylation, interfering with the net charges of the nucleosomes, is a key player in this regulation.
Mattia Zaghi +22 more
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Local and regional heterogeneity underlying hippocampal modulation of cognition and mood. [PDF]
, 2014 While the hippocampus has been classically studied for its role in learning and memory, there is significant support for a role of the HPC in regulating emotional behavior.
Jimenez, Jessica C +2 more
core +2 more sources
Signaling pathways linking behavior to neurogenesis in healthy brain and disease [PDF]
, 2020 Self-repair of the adult brain is limited – most diseases lack effective therapy. In order to better understand how a regenerative response can be achieved, studying mechanisms shaping the neurogenic niche, from environmental factors to intrinsic ...
Klempin, Friederike
core +1 more source
Ependymal cilia beating induces an actin network to protect centrioles against shear stress
Nature Communications, 2018 Ependymal ciliary beating contributes to the flow of cerebrospinal fluid in the brain ventricles and these cilia resist the flow forces. Here the authors show that the assembly of a dense actin network around the centrioles is induced by cilia beating to
Alexia Mahuzier +12 more
doaj +1 more source
Cell Reports, 2019 Summary: Stem cell-derived neurons are generally obtained in mass cultures that lack both spatial organization and any meaningful connectivity. We implement a microfluidic system for long-term culture of human neurons with patterned projections and ...
Angelo Iannielli +9 more
doaj +1 more source
eLife, 2020 Rett syndrome is an incurable neurodevelopmental disorder caused by mutations in the gene encoding for methyl-CpG binding-protein 2 (MeCP2). Gene therapy for this disease presents inherent hurdles since MECP2 is expressed throughout the brain and its ...
Mirko Luoni +12 more
doaj +1 more source
eLife, 2023 The rubella virus can interfere with fetal brain development by infecting immune cells called microglia during pregnancy.
Ekaterina Epifanova, Laurent Nguyen
doaj +1 more source
Modulation of adult-born neurons in the inflamed hippocampus. [PDF]
, 2013 Throughout life new neurons are continuously added to the hippocampal circuitry involved with spatial learning and memory. These new cells originate from neural precursors in the subgranular zone of the dentate gyrus, migrate into the granule cell layer,
Belarbi, Karim, Rosi, Susanna
core +2 more sources
Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability [PDF]
, 2017 Oligophrenin-1 (OPHN1) is a Rho GTPase activating protein whose mutations cause X-linked intellectual disability (XLID). How loss of function of Ophnl affects neuronal development is only partly understood.
Allegra, M +7 more
core +1 more source