Results 21 to 30 of about 142,373 (148)
Frontiers in Cell and Developmental Biology, 2021 TBL1XR1 gene is associated with multiple developmental disorders presenting several neurological aspects. The relative protein is involved in the modulation of important cellular pathways and master regulators of transcriptional output, including nuclear
Giuseppina Mastrototaro +19 more
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Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors
Frontiers in Neuroscience, 2019 In recent years, the need to derive sources of specialized cell types to be employed for cell replacement therapies and modeling studies has triggered a fast acceleration of novel cell reprogramming methods.
Gaia Colasante +5 more
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Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition
Nature Communications, 2023 Within the chromatin, distal elements interact with promoters to regulate specific transcriptional programs. Histone acetylation, interfering with the net charges of the nucleosomes, is a key player in this regulation.
Mattia Zaghi +22 more
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Ependymal cilia beating induces an actin network to protect centrioles against shear stress
Nature Communications, 2018 Ependymal ciliary beating contributes to the flow of cerebrospinal fluid in the brain ventricles and these cilia resist the flow forces. Here the authors show that the assembly of a dense actin network around the centrioles is induced by cilia beating to
Alexia Mahuzier +12 more
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Cell Reports, 2019 Summary: Stem cell-derived neurons are generally obtained in mass cultures that lack both spatial organization and any meaningful connectivity. We implement a microfluidic system for long-term culture of human neurons with patterned projections and ...
Angelo Iannielli +9 more
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eLife, 2020 Rett syndrome is an incurable neurodevelopmental disorder caused by mutations in the gene encoding for methyl-CpG binding-protein 2 (MeCP2). Gene therapy for this disease presents inherent hurdles since MECP2 is expressed throughout the brain and its ...
Mirko Luoni +12 more
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eLife, 2023 The rubella virus can interfere with fetal brain development by infecting immune cells called microglia during pregnancy.
Ekaterina Epifanova, Laurent Nguyen
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Neurobiology of Disease, 2009 In recent years, GDNF has emerged as a protective and restorative agent in several models of neurodegeneration; however, the exact molecular mechanisms responsible for these effects are not yet fully understood. Here we examined the effects of astrocytes
Jagdeep K. Sandhu +8 more
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Human Amniotic Fluid Cells Form Functional Gap Junctions with Cortical Cells
Stem Cells International, 2012 The usage of stem cells is a promising strategy for the repair of damaged tissue in the injured brain. Recently, amniotic fluid (AF) cells have received a lot of attention as an alternative source of stem cells for cell-based therapies.
Anna Jezierski +6 more
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Frontiers in Cellular Neuroscience, 2022 The adult neurogenic niches are complex multicellular systems, receiving regulatory input from a multitude of intracellular, juxtacrine, and paracrine signals and biological pathways. Within the niches, adult neural stem cells (aNSCs) generate astrocytic
Amber Penning +7 more
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