Results 21 to 30 of about 22,201 (325)

P2X receptors in neuroglia [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
AbstractDifferent types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X1/5 heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in ...
Verkhratsky, A., Pankratov, Y., Lalo, U., Nedergaard, M.   +3 more
openaire   +4 more sources

Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep

Frontiers in Integrative Neuroscience, 2017
As part of the extracellular matrix (ECM), perineuronal nets (PNs) are polyanionic, chondroitin sulfate proteoglycan (CSPG)-rich coatings of certain neurons, known to be affected in various neural diseases.
Wolfgang Härtig, Bianca Mages, Bianca Mages, Susanne Aleithe, Susanne Aleithe, Björn Nitzsche, Björn Nitzsche, Stephan Altmann, Stephan Altmann, Henryk Barthel, Martin Krueger, Dominik Michalski   +11 more
doaj   +1 more source

Clearance Systems in the Brain, From Structure to Function

Frontiers in Cellular Neuroscience, 2022
As the most metabolically active organ in the body, there is a recognized need for pathways that remove waste proteins and neurotoxins from the brain. Previous research has indicated potential associations between the clearance system in the brain and ...
Jiachen Liu, Yunzhi Guo, Chengyue Zhang, Yang Zeng, Yongqi Luo, Gaiqing Wang, Gaiqing Wang   +6 more
doaj   +1 more source

Purinoceptors on Neuroglia [PDF]

Molecular Neurobiology, 2009
Purinergic transmission is one of the most ancient and widespread extracellular signalling systems. In the brain, purinergic signalling plays a unique role in integrating neuronal and glial cellular circuits, as virtually every type of glial cell possesses receptors to purines and pyrimidines.
Alexei, Verkhratsky, Alexei, Verkhrasky, Oleg A, Krishtal, Geoffrey, Burnstock   +3 more
openaire   +4 more sources

The Concept of Neuroglia [PDF]

, 2019
Neuroglia represent a diverse population of non-neuronal cells in the nervous systems, be that peripheral, central, enteric or autonomic nervous system. Arguably, these cells represent about half of the volume of the human brain. This volumetric ratio, and by extension glia to neurone ratio, not only widely differ depending on the size of the animal ...
Robert Zorec, Margaret S. Ho, Alexei Verkhratsky, Alexei Verkhratsky, Alexei Verkhratsky, Vladimir Parpura   +5 more
openaire   +5 more sources

Soursop leaf extract increases neuroglia and hepatic degeneration in female rats

Universa Medicina, 2016
BACKGROUND Soursop leaf contains annonaceous acetogenins and alkaloids. The acetogenins act as inhibitors of mitochondrial complex I, suppress ATP production and cause cell degeneration, whereas the alkaloids act as neurotoxins.
Ety Sri Handayani, Zainuri Sabta Nugraha, Prilly i Raleka Pahlevawati   +2 more
doaj   +1 more source

Localization of NG2 immunoreactive neuroglia cells in the rat locus coeruleus and their plasticity in response to stress [PDF]

, 2014
The locus coeruleus (LC) nucleus modulates adaptive behavioural responses to stress and dysregulation of LC neuronal activity is implicated in stress-induced mental illnesses.
Corteen, Nicole L, Metzger, Friedrich, Seifi, Mohsen, Swinny, Jerome D, van der Want, Johannes J   +4 more
core   +3 more sources

Astrocytes as a target for therapeutic strategies in epilepsy: current insights

Frontiers in Molecular Neuroscience, 2023
Astrocytes are specialized non-neuronal glial cells of the central nervous system, contributing to neuronal excitability and synaptic transmission (gliotransmission). Astrocytes play a key roles in epileptogenesis and seizure generation.
Nihan Çarçak, Nihan Çarçak, Filiz Onat, Filiz Onat, Evgenia Sitnikova   +4 more
doaj   +1 more source

Subcellular organization of UBE3A in human cerebral cortex. [PDF]

, 2018
BackgroundLoss of UBE3A causes Angelman syndrome, whereas excess UBE3A activity appears to increase the risk for autism. Despite this powerful association with neurodevelopmental disorders, there is still much to be learned about UBE3A, including its ...
Burette, Alain C, Chang, Edward F, Judson, Matthew C, Li, Alissa N, Philpot, Benjamin D, Seeley, William W, Weinberg, Richard J   +6 more
core   +3 more sources

A Milled Microdevice to Advance Glia-Mediated Therapies in the Adult Nervous System

Micromachines, 2019
Neurodegenerative disorders affect millions of adults worldwide. Neuroglia have become recent therapeutic targets due to their reparative abilities in the recycling of exogenous neurotoxins and production of endogenous growth factors for proper ...
Juan S. Peña, Denise Robles, Stephanie Zhang, Maribel Vazquez   +3 more
doaj   +1 more source