Results 21 to 30 of about 21,877 (290)

Focused Ultrasound-Mediated Blood–Brain Barrier Opening Best Promotes Neuroimmunomodulation through Brain Macrophage Redistribution

Neuroglia, 2023
Neuroimmunomodulation is a promising form of drug-free treatment for neurological diseases ranging from Alzheimer’s disease to depression. The evidence supporting the efficacy of focused ultrasound (FUS) neuroimmunomodulation is encouraging; however, the
Alina R. Kline-Schoder, Rebecca L. Noel, Hemali Phatnani, Vilas Menon, Elisa E. Konofagou   +4 more
doaj   +1 more source

Mechanistic insights into connexin-mediated neuroglia crosstalk in neurodegenerative diseases. [PDF]

Front Cell Neurosci
Denaro S, D'Aprile S, Vicario N, Parenti R.   +3 more
europepmc   +2 more sources

Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep

Frontiers in Integrative Neuroscience, 2017
As part of the extracellular matrix (ECM), perineuronal nets (PNs) are polyanionic, chondroitin sulfate proteoglycan (CSPG)-rich coatings of certain neurons, known to be affected in various neural diseases.
Wolfgang Härtig, Bianca Mages, Bianca Mages, Susanne Aleithe, Susanne Aleithe, Björn Nitzsche, Björn Nitzsche, Stephan Altmann, Stephan Altmann, Henryk Barthel, Martin Krueger, Dominik Michalski   +11 more
doaj   +1 more source

Metabotropic Glutamate Receptor 5 Antagonism Reduces Pathology and Differentially Improves Symptoms in Male and Female Heterozygous zQ175 Huntington’s Mice

Frontiers in Molecular Neuroscience, 2022
Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disorder that leads to progressive motor and cognitive impairment. There are currently no available disease modifying treatments for HD patients. We have previously shown that
Si Han Li, Si Han Li, Tash-Lynn L. Colson, Tash-Lynn L. Colson, Khaled S. Abd-Elrahman, Khaled S. Abd-Elrahman, Khaled S. Abd-Elrahman, Stephen S. G. Ferguson, Stephen S. G. Ferguson   +8 more
doaj   +1 more source

Soursop leaf extract increases neuroglia and hepatic degeneration in female rats

Universa Medicina, 2016
BACKGROUND Soursop leaf contains annonaceous acetogenins and alkaloids. The acetogenins act as inhibitors of mitochondrial complex I, suppress ATP production and cause cell degeneration, whereas the alkaloids act as neurotoxins.
Ety Sri Handayani, Zainuri Sabta Nugraha, Prilly i Raleka Pahlevawati   +2 more
doaj   +1 more source

Head-to-Head Study of Developmental Neurotoxicity and Resultant Phenotype in Rats: α-Hexabromocyclododecane versus Valproic Acid, a Recognized Model of Reference for Autism Spectrum Disorders

Toxics, 2022
Evidence is now growing that exposure to environmental pollutants during the critical early-life period of brain development may contribute to the emergence of Autism Spectrum Disorders (ASD).
Chloé Morel, Armelle Christophe, Katy Maguin-Gaté, Justine Paoli, Jonathan David Turner, Henri Schroeder, Nathalie Grova   +6 more
doaj   +1 more source

Pathophysiology of Lipid Droplets in Neuroglia

Antioxidants, 2021
In recent years, increasing evidence regarding the functional importance of lipid droplets (LDs), cytoplasmic storage organelles in the central nervous system (CNS), has emerged.
Tina Smolič, Robert Zorec, Nina Vardjan
doaj   +1 more source

A Milled Microdevice to Advance Glia-Mediated Therapies in the Adult Nervous System

Micromachines, 2019
Neurodegenerative disorders affect millions of adults worldwide. Neuroglia have become recent therapeutic targets due to their reparative abilities in the recycling of exogenous neurotoxins and production of endogenous growth factors for proper ...
Juan S. Peña, Denise Robles, Stephanie Zhang, Maribel Vazquez   +3 more
doaj   +1 more source

Combination of Engineered Expression of Polysialic Acid on Transplanted Schwann Cells and in Injured Rat Spinal Cord Promotes Significant Axonal Growth and Functional Recovery

Neuroglia, 2023
Providing cellular support and modifying the glial scar around the lesion are two key strategies for promoting axonal regeneration after spinal cord injury.
Fangyou Gao, Yi Zhang, Dongsheng Wu, Juan Luo, Svetlana Gushchina, Xuenong Bo   +5 more
doaj   +1 more source

Convergence of Pro-Stress and Pro-Inflammatory Signaling in the Central Noradrenergic System: Implications for Mood and Anxiety Disorders

Neuroglia, 2023
Mood and anxiety disorders are heterogeneous psychiatric diagnoses affecting millions. While the disease etiology is complex, various risk factors have been identified, such as stress.
Arthur Anthony A. Reyes, Daniel J. Chandler   +1 more
doaj   +1 more source