Results 91 to 100 of about 37,027 (220)

Divergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis

Allergy, EarlyView.
ABSTRACT Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects
Tali Czarnowicki, Kazunari Sugita, Zenas Yiu, Sandra Díez‐Ribas, Irene Garcia‐Jimenez, Emma Guttman‐Yassky, Luis F. Santamaria‐Babí   +6 more
wiley   +1 more source

A network medicine approach to investigating ME/CFS pathogenesis in severely ill patients: a pilot study

Frontiers in Human Neuroscience
This pilot study harnessed the power of network medicine to unravel the complex pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
Li-Yuan Hung, Chan-Shuo Wu, Chia-Jung Chang, Peng Li, Kimberly Hicks, Joshua J. Dibble, Braxton Morrison, Chimere L. Smith, Ronald W. Davis, Wenzhong Xiao   +9 more
doaj   +1 more source

Matrix Metalloproteinase-9 and Inflammation in Different Types of Multiple Sclerosis [PDF]

, 2016
Different clinical courses of multiple sclerosis, heterogeneity of its clinical implications, different effect of immunomodulatory therapy for the same clinical forms implies various pathogenetic mechanisms of central nervous system damage at this ...
Chernenko, M. (Maksym), Nehreba, T. (Tatyana), Vasylovskyy, V. (Vitaliy), Voloshyna, N. (Nataliya), Vovk, V. (Viktoriya)   +4 more
core   +2 more sources

Immune checkpoint inhibitor cardiomyotoxicity: a case series of five patients and development of a clinical management algorithm

Internal Medicine Journal, EarlyView.
Abstract Immune checkpoint inhibitor (ICI) therapies have revolutionised the management of a range of malignancies. However, the syndrome of ICI induced cardiomyotoxicity, also reported as triple “M” syndrome (myasthenia gravis, myositis and myocarditis) is an unfortunate severe consequence in up to 1%–2% of patients receiving ICI, with an associated ...
S. Z. Xie, J. E. Salem, A. Nagrial, A. Menzies, L. Thomas, S. Ramanathan, L. J. Berglund, S. C. Sasson, A. C. Grey, R. Habib, M. Wong, M. S. Carlino, B. Jeffrey, J. Mo, M. W. Lin   +14 more
wiley   +1 more source

The frequency of psoriasis in Australian multiple sclerosis patients

Frontiers in Neurology
BackgroundMultiple Sclerosis (MS) is an immune-mediated, demyelinating disease of the central nervous system. Although psoriasis and psoriasiform dermatitis are reported in MS patients, the prevalence of the diseases is uncertain globally and unstudied ...
Varitsara Mangkorntongsakul, Varitsara Mangkorntongsakul, Ariadna Fontes-Villalba, Ariadna Fontes-Villalba, Turlough Montague, Olivia Charlton, Chun-Ting Justin Kwong, Helen Marie McGuire, Venkatesha Venkatesha, Geoffrey Herkes, Geoffrey Herkes, Saxon Smith, Saxon Smith, Saxon Smith, John Parratt   +14 more
doaj   +1 more source

Increased Prevalence of Extrathymic Neoplasms in Myasthenia Gravis Patients‐A Population‐Based, Matched Case–Control Study

Muscle &Nerve, Volume 73, Issue 6, Page 1016-1024, June 2026.
ABSTRACT Introduction/Aims Myasthenia gravis (MG) is associated with thymic neoplasms. However, an increased prevalence of extrathymic neoplasms has also been reported. This study aimed to evaluate the rates of malignancy in MG patients while accounting for risk factors such as disease characteristics and immunomodulatory treatments.
Keshet Pardo, Tasneem Kab, Mark A. Hellmann, Itay Lotan, Tzippy Shochat, Nadav Loebl, Bar Yacobi, Yitzhak Friedman, Leor Perl, Nitai Shimon, Yiska Loewenberg Weisband, Liya Bieber, Eitan Auriel, Adi Wilf‐Yarkoni   +13 more
wiley   +1 more source

Possible Anti-Pain Vaccines: A Narrative Review of Emerging Strategies and Clinical Prospects

Vaccines
Chronic pain affects millions of individuals globally and continues to pose a major burden on patients and healthcare systems. Traditional analgesics, such as opioids and nonsteroidal anti-inflammatory drugs, often provide only partial relief and are ...
Yuri Chaves Martins, Luciana Pereira De-Sousa, Peyton J. Murin, Hamed Sadeghipour, Cláudio Tadeu Daniel-Ribeiro   +4 more
doaj   +1 more source

Diffusion basis spectrum imaging for identifying pathologies in MS subtypes [PDF]

, 2019
Diffusion basis spectrum imaging (DBSI) combines discrete anisotropic diffusion tensors and the spectrum of isotropic diffusion tensors to model the underlying multiple sclerosis (MS) pathologies. We used clinical MS subtypes as a surrogate of underlying
Cross, Anne H, George, Ajit, Naismith, Robert T, Perantie, Dana C, Schmidt, Robert E, Shirani, Afsaneh, Song, Sheng-Kwei, Sun, Peng, Trinkaus, Kathryn   +8 more
core   +2 more sources

Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1

Annals of Neurology, Volume 99, Issue 5, Page 1173-1178, May 2026.
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan, Milo Fonville, Mabel Hoekstra, Rolf Fronczek, Joost Smolders, Dick F. Swaab   +5 more
wiley   +1 more source

Rapid entry and downregulation of T Cells in the central nervous system During the reinduction of experimental autoimmune encephalomyelitis [PDF]

, 2001
We investigated the mechanisms whereby a previous attack of experimental autoimmune encephalomyelitis (EAE) modifies a subsequent attack in the Lewis rat.
C.A. White, Deibler, Ding, F.L. Gordon, Hinrichs, Imrich, K.B. Nguyen, Kerr, Levine, Levine, Levine, Levine, Lou, M.P. Pender, MacPhee, McCombe, Mostarica-Stojkovic, Namikawa, Nguyen, Nguyen, Offner, Offner, O’Brien, Panitch, Pender, Pender, Pender, Pender, Pender, Schmied, Sun, Swierkosz, Tabi, Tabi, Torres-Nagel, Welch, White, White, White, Willenborg   +39 more
core   +1 more source