Results 81 to 90 of about 37,027 (220)

Serum NfL, GFAP, and p‐tau217 in adults with drug‐resistant epilepsy and intellectual disabilities: Signs of ongoing neural injury

Epilepsia, EarlyView.
Abstract Objective Adults with epilepsy and intellectual disabilities (IDs) may be at increased risk of dementia, but clinical evaluation is complex and use of conventional biomarkers is often considered too invasive. We explored abnormality of serum neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and phosphorylated tau‐217 (p ...
Hadassa Kwetsie, Inge M. W. Verberk, Jans S. van Ool, Anneke J. J. Rampen, Rebecca Z. Rousset, Nicole I. Wolf, Dederieke A. M. Maes‐Festen, Clara D. M. van Karnebeek, Charlotte E. Teunissen, Erik Boot, Agnies M. van Eeghen   +10 more
wiley   +1 more source

Sudden Infant Death Syndrome, Infection, Prone Sleep Position, and Vagal Neuroimmunology

Frontiers in Pediatrics, 2017
Recent findings suggest that infection (and sepsis) stand alone as the only plausible mechanism of causation of sudden infant death syndrome (SIDS) and accordingly achieves congruence with all clinicopathological and epidemiological findings. This review
Paul Nathan Goldwater
doaj   +1 more source

Current Advances in Pediatric Onset Multiple Sclerosis

Biomedicines, 2020
Multiple sclerosis (MS) is an autoimmune inflammatory disease affecting the central nervous system leading to demyelination. MS in the pediatric population is rare, but has been shown to lead to significant disability over the duration of the disease. As
Kristen S. Fisher, Fernando X. Cuascut, Victor M. Rivera, George J. Hutton   +3 more
doaj   +1 more source

Vaccine strategy when the smallpox model fails: 1. immune cognition, Malaria and the Fulani [PDF]

, 2001
We begin to examine the implications of IR Cohen's work on immune cognition [1-3] for vaccine strategies when simple elicitation of sterilizing immunity fails, as is the case for HIV, tuberculosis, and malaria.
Wallace, Robert G, Wallace, Rodrick
core  

In Vivo Mapping of Catecholaminergic Loss and Iron Deposition in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background The pathophysiology of Huntington's disease (HD) remains obscure. Magnetic resonance imaging (MRI) can reveal in vivo molecular changes related to disease pathology. Objectives To investigate catecholaminergic neuronal integrity and subcortical brain iron accumulation in HD employing neuromelanin‐sensitive MRI, and quantitative ...
Edoardo R. de Natale, Heather Wilson, Efstratios Karavasilis, Athanasia Liozidou, Chrisoula Kartanou, Georgios Velonakis, Jens Kuhle, Ioannis Zalonis, Georgia Karadima, Leonidas Stefanis, Georgios Koutsis, Marios Politis   +11 more
wiley   +1 more source

ipRGCs Sensitive Blue Light Exposure Promotes the Robustness of Circadian and Neural Stem Cells in Sleep Deprived Conditions

Stem Cells International
Circadian rhythm abnormalities due to sleep deprivation (SD) may promote the development of emotional and cognitive disorders. Though light therapies have been employed to treat circadian disorders, the exact treatments and their underlying biology are ...
Zhaoting Bu, Xiaotong Li, Jinyu Shi, Qiaozhen Qin, Heyang Zhang, Yuanrong Qiu, Lingyu Zhang, Yifei Tan, Hanping Shi, Xiaoxia Jiang   +9 more
doaj   +1 more source

The effects of an intronic polymorphism in TOMM40 and APOE genotypes in sporadic inclusion body myositis. [PDF]

, 2015
A previous study showed that, in carriers of the apolipoprotein E (APOE) genotype ε3/ε3 or ε3/ε4, the presence of a very long (VL) polyT repeat allele in "translocase of outer mitochondrial membrane 40" (TOMM40) was less frequent in patients with ...
Barohn, R.J., Bettencourt, C., Brady, S., De Bleecker, J., De Paepe, B., Dimachkie, M.M., Fox, Z., Gang, Q., Hanna, M.G., Healy, E., Hilton-Jones, D., Holton, J.L., Houlden, H., Machado, P.M., Mantegazza, R., Mastaglia, F., Moggio, M., Mora, M., Needham, M., Parton, M., Ripolone, M., Shaibani, A., Shieh, P.B., Violano, R., Zanoteli, E., Zanotti, S.   +25 more
core   +1 more source

Quality of Life in Patients With Chronic Inflammatory Demyelinating Polyneuropathy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare disorder of the nervous system that detrimentally influences health‐related quality of life (HRQoL). Evidence regarding factors influencing HRQoL in CIDP is scarce.
Tobias C. Blum, Hendrik van der Wurp, David Mengel, Linda Fraune, Norbert Sommer, Mark Stettner, Björn Tackenberg, Richard Dodel   +7 more
wiley   +1 more source

Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex. [PDF]

, 1989
Insertion/deletion related polymorphisms (IDRP) involving stretches of 15-30 kb within the human TCR-beta gene complex were revealed by pulse-field gel electrophoresis.
Hauser, SL, Kindt, TJ, Robinson, MA, Seboun, E   +3 more
core  

A Haystack Heuristic for Autoimmune Disease Biomarker Discovery Using Next-Gen Immune Repertoire Sequencing Data. [PDF]

, 2017
Large-scale DNA sequencing of immunological repertoires offers an opportunity for the discovery of novel biomarkers for autoimmune disease. Available bioinformatics techniques however, are not adequately suited for elucidating possible biomarker ...
Apeltsin, Leonard, Sirota, Marina, von Büdingen, H-Christian, Wang, Shengzhi   +3 more
core   +1 more source