Results 81 to 90 of about 25,871 (216)

Changes in Brain Neuroimmunology Following Injury and Disease

, 2022
The nervous and immune systems are intimately related in the brain and in the periphery, where changes to one affect the other and vice-versa. Immune cells are responsible for sculpting and pruning neuronal synapses, and play key roles in neuro ...
Tabet, Anthony, Apra, Caroline, Stranahan, Alexis M., Anikeeva, Polina   +3 more
core   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Systems neuroimmunology: current bottlenecks, research priorities and future directions [Comment]

International audienceStrategies to advance the field of neuroimmunology by embracing its complexity via inclusion of its multidisciplinary properties were discussed at a meeting in Cold Spring Harbor.
Boulanger, Lisa, Klein, Robyn, Sokol, Caroline L, Burton, Michael, Irazoqui, Javier, Grace, Peter M, Salinas, Irene, Klein, Robyn S, Schaefer, Anne, Rosi, Susanna, Bilbo, Staci, Flajnik, Martin, Flajnik, Martin F, Grace, Peter, Bilbo, Staci D, Iyer, Harini, Burton, Michael D, Gareau, Mélanie, Daniels, Brian, Williams, Dionna, Sokol, Caroline, Irazoqui, Javier E, Boulanger, Lisa M, Daniels, Brian P, Gareau, Mélanie G, Benoist, Christophe, Williams, Dionna W, Deczkowska, Aleksandra   +27 more
core   +1 more source

ipRGCs Sensitive Blue Light Exposure Promotes the Robustness of Circadian and Neural Stem Cells in Sleep Deprived Conditions

Stem Cells International
Circadian rhythm abnormalities due to sleep deprivation (SD) may promote the development of emotional and cognitive disorders. Though light therapies have been employed to treat circadian disorders, the exact treatments and their underlying biology are ...
Zhaoting Bu, Xiaotong Li, Jinyu Shi, Qiaozhen Qin, Heyang Zhang, Yuanrong Qiu, Lingyu Zhang, Yifei Tan, Hanping Shi, Xiaoxia Jiang   +9 more
doaj   +1 more source

A network medicine approach to investigating ME/CFS pathogenesis in severely ill patients: a pilot study

Frontiers in Human Neuroscience
This pilot study harnessed the power of network medicine to unravel the complex pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
Li-Yuan Hung, Chan-Shuo Wu, Chia-Jung Chang, Peng Li, Kimberly Hicks, Joshua J. Dibble, Braxton Morrison, Chimere L. Smith, Ronald W. Davis, Wenzhong Xiao   +9 more
doaj   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 1978-1992, October 2026.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

The frequency of psoriasis in Australian multiple sclerosis patients

Frontiers in Neurology
BackgroundMultiple Sclerosis (MS) is an immune-mediated, demyelinating disease of the central nervous system. Although psoriasis and psoriasiform dermatitis are reported in MS patients, the prevalence of the diseases is uncertain globally and unstudied ...
Varitsara Mangkorntongsakul, Varitsara Mangkorntongsakul, Ariadna Fontes-Villalba, Ariadna Fontes-Villalba, Turlough Montague, Olivia Charlton, Chun-Ting Justin Kwong, Helen Marie McGuire, Venkatesha Venkatesha, Geoffrey Herkes, Geoffrey Herkes, Saxon Smith, Saxon Smith, Saxon Smith, John Parratt   +14 more
doaj   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2036-2045, October 2026.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Neuroimmunology [PDF]

Proceedings of the Royal Society of Medicine, 1977
R A, Hughes, I, Gray, R, Clifford-Jones, M, Stern   +3 more
  +9 more sources

Possible Anti-Pain Vaccines: A Narrative Review of Emerging Strategies and Clinical Prospects

Vaccines
Chronic pain affects millions of individuals globally and continues to pose a major burden on patients and healthcare systems. Traditional analgesics, such as opioids and nonsteroidal anti-inflammatory drugs, often provide only partial relief and are ...
Yuri Chaves Martins, Luciana Pereira De-Sousa, Peyton J. Murin, Hamed Sadeghipour, Cláudio Tadeu Daniel-Ribeiro   +4 more
doaj   +1 more source