Results 101 to 110 of about 24,021 (224)

APOE*4 risk‐modifying genes and drug targets in Alzheimer's disease through cell‐type‐specific genomic analyses

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Genetics studies can identify drug targets that counteract the effects of the apolipoprotein E ε4 allele (APOE*4) on Alzheimer's disease (AD) but have remained limited in power and crucially did not assess genetic findings with regard to APOE*4's cell‐type‐specific impact on pathobiology.
Youjie Zeng, Noah Cook, Chenyu Yang, Sathesh K. Sivasankaran, Masashi Fujita, Zachary A. Gardell, Yann Le Guen, Daichi Shigemizu, Kouichi Ozaki, Takashi Morizono, Norikazu Hara, Akinori Miyashita, Takeshi Ikeuchi, Cyril Pottier, Carlos Cruchaga, Valerio Napolioni, M. Ryan Corces, Vilas Menon, Michael D. Greicius, Michael E. Belloy   +19 more
wiley   +1 more source

CSF‐Compartmentalized Antibody Glycoprofiles in NMDAR Encephalitis Associate with Etiology and Functional Recovery

Annals of Neurology, Volume 99, Issue 6, Page 1468-1479, June 2026.
Objective To characterize Fc‐glycosylation profiles in patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis (NMDARe) and assess their association with antibody compartmentalization (cerebrospinal fluid [CSF] vs serum), disease triggers (viral, tumor‐related or idiopathic), and 1‐year outcomes.
Laura Marmolejo, Claudia Papi, Chiara Milano, Esther Aguilar, Estibaliz Maudes, Ivana Duvnjak Orešković, Jerko Štambuk, Maja Pučić‐Baković, Gemma Olivé‐Cirera, Elianet Fonseca, Mar Guasp, Eugenia Martinez‐Hernandez, Helena Ariño, Takahiro Iizuka, Thais Armangué, Josep Dalmau, Marianna Spatola   +16 more
wiley   +1 more source

Spotlight on Neuroimmunology: Illustrations from Neurodegenerative Diseases

, 2017
The immune system plays key roles in the defense of the organism. However, the effects of the immune system are not limited to the immune functions and have impacts beyond the anti-pathogenes role. Indeed, neuroimmunology is a representative field of how
Boubertakh, Besma, Besma Boubertakh, Abdelaziz Ghanemi, Ghanemi, Abdelaziz   +3 more
core   +1 more source

Animal models of myasthenia gravis: utility and limitations

International Journal of General Medicine, 2016
Renato Mantegazza, Chiara Cordiglieri, Alessandra Consonni, Fulvio Baggi Neurology IV Unit, Neuroimmunology and Neuromuscular Disorders, Foundation IRCCS Neurological Institute “Carlo Besta”, Milan, Italy Abstract: Myasthenia gravis (MG) is ...
Mantegazza R, Cordiglieri C, Consonni A, Baggi F   +3 more
doaj  

Hyperreflective Foci in the Inner Nuclear Layer: Proof‐of‐Concept for an Optical Coherence Tomography Derived Microglia‐Related Marker in Multiple Sclerosis

Annals of Neurology, Volume 99, Issue 6, Page 1480-1485, June 2026.
The role of microglia has emerged as a critical driver of disease progression in multiple sclerosis (MS), but we lack broadly applicable monitoring tools. Here, we investigated whether hyperreflective foci (HRF), as detected by optical coherence tomography (OCT) within the inner nuclear layer (INL) of the retina, can be used as a marker for microglial ...
Jonathan A. Gernert, Laura M. Bartos, Tara Christmann, Hanna Zausinger, Luca N. Diedrich, Daniel Engels, Miriam Schlüter, Sarah Schlaeger, Sophia Stoecklein, Leonie F. Keidel, Tania Kümpfel, Martin Kerschensteiner, Matthias Brendel, Joachim Havla   +13 more
wiley   +1 more source

RECEPTOR MACHINERY INVOLVED IN MBP-INDUCED ASTROCYTE ACTIVATIONVII International Congress of Neuroimmunology (International Society of Neuroimmunology.

, 2004
Our data suggest that MBP interacts with astroglial cells, priming their activation, as proven by HLA class II modulation and HO-1 induction. MBP binding seems to be mediated by LRP,an endocytosis-mediating receptor.
BUSINARO R., FUMAGALLI L., LEONE, STEFANO, LAURO, Giuliana Maria   +3 more
core  

Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Nicole Rychlik, Kay Jüngling, Sven G. Meuth, Thomas Budde, Marta Méndez‐Couz   +4 more
wiley   +1 more source

Mapping Immunity With Cutting‐Edge Spatial Biology and Tissue Cytometry Innovations

MedComm, Volume 7, Issue 6, June 2026.
This review explores how spatial biology integrates multiplexed imaging and tissue cytometry to reveal immune organization within native tissue contexts. ABSTRACT The immune system operates within organized tissue landscapes, where spatial relationships between cells shape the nature and outcome of immune responses.
Lilibeth Cárdenas‐Piedra, Selwin G. Samuel, Felicitas Mungenast, Dinesh Yasothkumar, Rupert C. Ecker, Jyotsna Batra   +5 more
wiley   +1 more source

Increased Prevalence of Extrathymic Neoplasms in Myasthenia Gravis Patients‐A Population‐Based, Matched Case–Control Study

Muscle &Nerve, Volume 73, Issue 6, Page 1016-1024, June 2026.
ABSTRACT Introduction/Aims Myasthenia gravis (MG) is associated with thymic neoplasms. However, an increased prevalence of extrathymic neoplasms has also been reported. This study aimed to evaluate the rates of malignancy in MG patients while accounting for risk factors such as disease characteristics and immunomodulatory treatments.
Keshet Pardo, Tasneem Kab, Mark A. Hellmann, Itay Lotan, Tzippy Shochat, Nadav Loebl, Bar Yacobi, Yitzhak Friedman, Leor Perl, Nitai Shimon, Yiska Loewenberg Weisband, Liya Bieber, Eitan Auriel, Adi Wilf‐Yarkoni   +13 more
wiley   +1 more source

Research priorities for neuroimmunology: identifying the key research questions to be addressed by 2030 [PDF]

Neuroimmunology in the broadest sense is the study of interactions between the nervous and the immune systems. These interactions play important roles in health from supporting neural development, homeostasis and plasticity to modifying behaviour ...
Mondelli, V, Caldwell, LJ, Teeling, JL, Upthegrove, R, Harrison, NA, Liston, A, Pariante, C, Shah, DK, Khandaker, GM, MacKenzie, G, Irani, SR, Morgan, BP, Hong, S, Taams, LS, Subramaniam, S, Miron, VE, Fitzgerald, D   +16 more
core