Results 61 to 70 of about 25,871 (216)

The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection

mBio, 2019
Interferons (IFNs) and autophagy are critical neuronal defenses against viral infection. IFNs alter neuronal autophagy by promoting the accumulation of IFN-dependent LC3-decorated autophagic structures, termed LC3 clusters. Here, we analyzed LC3 clusters
Jorge Ruben Cabrera, Richard Manivanh, Brian J. North, David A. Leib   +3 more
doaj   +1 more source

Clinical and Genetic Factors Associated With Regression in Children With Autism Spectrum Disorders

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with complex genetic and environmental underpinnings. A clinically significant subset of children with ASD experience developmental regression (regASD), characterized by the acute loss of previously acquired skills. The mechanisms, predictors, and molecular basis of
Anna Maruani, Emma Delclaud, Paul Bruzeau, Richard Delorme, Anne‐Claude Tabet, Valérie Vantalon, Jonathan Levy, Pierre Ellul   +7 more
wiley   +1 more source

Selected Papers from CUBANNI 2017—“The Fourth International Workshop of Neuroimmunology” [PDF]

, 2019
Starting from the most interesting papers presented at CUBANNI 2017, the First International Meeting of the Cuban Network of Neuroimmunology, this eBook covers the most up-to-date findings on neuroimmunology research.
Maria De los Angeles Robinson Agramonte (Ed.), Carlos Alberto Gonçalves (Ed.), Dario Siniscalco (Ed.)   +2 more
core   +1 more source

Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain Injury

Frontiers in Cellular Neuroscience, 2019
The neuroinflammatory response to traumatic brain injury (TBI) is critical to both neurotoxicity and neuroprotection, and has been proposed as a potentially modifiable driver of secondary injury in animal and human studies.
Saef Izzy, Saef Izzy, Saef Izzy, Saef Izzy, Qiong Liu, Qiong Liu, Zhou Fang, Zhou Fang, Zhou Fang, Zhou Fang, Sevda Lule, Sevda Lule, Limin Wu, Limin Wu, Joon Yong Chung, Joon Yong Chung, Aliyah Sarro-Schwartz, Aliyah Sarro-Schwartz, Alexander Brown-Whalen, Alexander Brown-Whalen, Caroline Perner, Caroline Perner, Caroline Perner, Suzanne E. Hickman, Suzanne E. Hickman, Suzanne E. Hickman, David L. Kaplan, Nikolaos A. Patsopoulos, Nikolaos A. Patsopoulos, Nikolaos A. Patsopoulos, Nikolaos A. Patsopoulos, Joseph El Khoury, Joseph El Khoury, Joseph El Khoury, Michael J. Whalen, Michael J. Whalen, Michael J. Whalen   +36 more
doaj   +1 more source

Microglia, seen from the CX3CR1 angle

Frontiers in Cellular Neuroscience, 2013
Microglial cells in brain and spinal cord are characterized by high expression of the chemokine receptor CX3CR1. Expression of the sole CX3CR1 ligand, the membrane-tethered and sheddable chemokine CX3CL1/ fractalkine, is restricted in the brain ...
Yochai eWolf, Simon eYona, Simon eYona, Ki-Wook eKim, Ki-Wook eKim, Steffen eJung   +5 more
doaj   +1 more source

Lysosomal Expression Profile in Plasma Associates with Disease Severity in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a clinically and biologically heterogeneous neurodegenerative disorder, driven by multiple mechanisms among which are lysosomal and mitochondrial dysfunction. Here, we explored blood‐based lysosomal and mitochondrial profiles in relation to PD diagnosis and severity.
Janna van Wetering, Manon M. van Ingen, Evelien Timmermans, Sjors G.J.G. in't Veld, Henk W. Berendse, Charlotte E. Teunissen, Wilma D.J. van de Berg   +6 more
wiley   +1 more source

Intrathecal IgM production correlates with more severe disease course in multiple sclerosis: Clinical and MRI results

, 2014
12th International Congress of Neuroimmunology (ISNI) -- NOV 09-13, 2014 -- Mainz, GERMANYWOS ...
Ozcelik, Pinar, KAYA ÖZÇELİK, PINAR, Ozakbas, Serkan, Kosehasanogullari, Gorkem, Baser, Hatice, Cinar, Bilge Piri   +5 more
core   +1 more source

The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders

Brain Pathology, EarlyView.
Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu, Yoshiki Takai, Naoya Yamazaki, Sarah Brandl, Katharina M. Mair, Thibault Bouderlique, Maria Eleni Kastriti, Igor Adameyko, Romana Höftberger, Markus Reindl, Jan Bauer, Monika Bradl   +11 more
wiley   +1 more source

Innate immune response in traumatic Spinal Cord Injury (SCI), a beneficial regulatory role for MIS416

, 2018
The precise temporal dynamics of inflammatory responses post spinal cord injury (SCI), and its significance for recovery, remain largely unknown.
Wesbster, Gill, Breit, Samuel N., Hassanpour Golakani, Masoud (R20679), Li, Hui, Ruitenberg, Marc J., Brown, David A., Mohammad, Mohammad G.   +6 more
core  

Spotlight on Neuroimmunology: Illustrations from Neurodegenerative Diseases [PDF]

, 2017
The immune system plays key roles in the defense of the organism. However, the effects of the immune system are not limited to the immune functions and have impacts beyond the anti-pathogenes role. Indeed, neuroimmunology is a representative field of how
Boubertakh, Besma, Besma Boubertakh, Abdelaziz Ghanemi, Ghanemi, Abdelaziz   +3 more
core   +1 more source